Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson’s disease
Resolvins are endogenous lipids with pro-resolving activity. Here the authors find that rats overexpressing human α-synuclein show defects in dopamine signalling before dopamine cell loss, and that this is associated with low Resolvin D1 levels and neuroinflammation.
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Nature Portfolio
2019
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oai:doaj.org-article:4400ee42af354c6ca10e2b68760be2262021-12-02T15:35:16ZBlunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson’s disease10.1038/s41467-019-11928-w2041-1723https://doaj.org/article/4400ee42af354c6ca10e2b68760be2262019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11928-whttps://doaj.org/toc/2041-1723Resolvins are endogenous lipids with pro-resolving activity. Here the authors find that rats overexpressing human α-synuclein show defects in dopamine signalling before dopamine cell loss, and that this is associated with low Resolvin D1 levels and neuroinflammation.Paraskevi KrashiaAlberto CordellaAnnalisa NobiliLivia La BarberaMauro FedericiAlessandro LeutiFederica CampanelliGiuseppina NataleGioia MarinoValeria CalabreseFrancescangelo VedeleVeronica GhiglieriBarbara PicconiGiulia Di LazzaroTommaso SchirinziGiulia SancesarioNicolas CasadeiOlaf RiessSergio BernardiniAntonio PisaniPaolo CalabresiMaria Teresa ViscomiCharles Nicholas SerhanValerio ChiurchiùMarcello D’AmelioNicola Biagio MercuriNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-19 (2019) |
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DOAJ |
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EN |
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Science Q Paraskevi Krashia Alberto Cordella Annalisa Nobili Livia La Barbera Mauro Federici Alessandro Leuti Federica Campanelli Giuseppina Natale Gioia Marino Valeria Calabrese Francescangelo Vedele Veronica Ghiglieri Barbara Picconi Giulia Di Lazzaro Tommaso Schirinzi Giulia Sancesario Nicolas Casadei Olaf Riess Sergio Bernardini Antonio Pisani Paolo Calabresi Maria Teresa Viscomi Charles Nicholas Serhan Valerio Chiurchiù Marcello D’Amelio Nicola Biagio Mercuri Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson’s disease |
| description |
Resolvins are endogenous lipids with pro-resolving activity. Here the authors find that rats overexpressing human α-synuclein show defects in dopamine signalling before dopamine cell loss, and that this is associated with low Resolvin D1 levels and neuroinflammation. |
| format |
article |
| author |
Paraskevi Krashia Alberto Cordella Annalisa Nobili Livia La Barbera Mauro Federici Alessandro Leuti Federica Campanelli Giuseppina Natale Gioia Marino Valeria Calabrese Francescangelo Vedele Veronica Ghiglieri Barbara Picconi Giulia Di Lazzaro Tommaso Schirinzi Giulia Sancesario Nicolas Casadei Olaf Riess Sergio Bernardini Antonio Pisani Paolo Calabresi Maria Teresa Viscomi Charles Nicholas Serhan Valerio Chiurchiù Marcello D’Amelio Nicola Biagio Mercuri |
| author_facet |
Paraskevi Krashia Alberto Cordella Annalisa Nobili Livia La Barbera Mauro Federici Alessandro Leuti Federica Campanelli Giuseppina Natale Gioia Marino Valeria Calabrese Francescangelo Vedele Veronica Ghiglieri Barbara Picconi Giulia Di Lazzaro Tommaso Schirinzi Giulia Sancesario Nicolas Casadei Olaf Riess Sergio Bernardini Antonio Pisani Paolo Calabresi Maria Teresa Viscomi Charles Nicholas Serhan Valerio Chiurchiù Marcello D’Amelio Nicola Biagio Mercuri |
| author_sort |
Paraskevi Krashia |
| title |
Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson’s disease |
| title_short |
Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson’s disease |
| title_full |
Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson’s disease |
| title_fullStr |
Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson’s disease |
| title_full_unstemmed |
Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson’s disease |
| title_sort |
blunting neuroinflammation with resolvin d1 prevents early pathology in a rat model of parkinson’s disease |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/4400ee42af354c6ca10e2b68760be226 |
| work_keys_str_mv |
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