White versus gray matter function as seen on neuropsychological testing following bone marrow transplant for acute leukemia in childhood

Fiona S Anderson1, Alicia S Kunin-Batson1, Joanna L Perkins2, K Scott Baker31Divisions of Pediatric Clinical Neuroscience; 2Department of Pediatric Hematology/Oncology, Children&rsquo;s Hospitals and Clinics, Minneapolis, MN, USA and 3Hematology/Oncology/BMT, Department of Pediatrics, Univer...

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Autores principales:	Fiona S Anderson, Alicia S Kunin-Batson, Joanna L Perkins, K Scott Baker
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/44033395f1d64b7083317031f872a050
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spelling	oai:doaj.org-article:44033395f1d64b7083317031f872a0502021-12-02T06:36:29ZWhite versus gray matter function as seen on neuropsychological testing following bone marrow transplant for acute leukemia in childhood1176-63281178-2021https://doaj.org/article/44033395f1d64b7083317031f872a0502008-03-01T00:00:00Zhttp://www.dovepress.com/white-versus-gray-matter-function-as-seen-on-neuropsychological-testin-a1010https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Fiona S Anderson1, Alicia S Kunin-Batson1, Joanna L Perkins2, K Scott Baker31Divisions of Pediatric Clinical Neuroscience; 2Department of Pediatric Hematology/Oncology, Children&rsquo;s Hospitals and Clinics, Minneapolis, MN, USA and 3Hematology/Oncology/BMT, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USAAbstract: Current theory suggests that neurocognitive late effects of treatments for childhood cancer such as difficulties with attention, processing speed and visual-motor ability are the result of white matter damage. Neuroimaging studies have produced a variety of white matter findings. However, although white matter is thought to be differentially affected, previous studies have not demonstrated a discrepancy between white and gray matter function. The present study included 36 children treated for childhood leukemia with hematopoietic stem cell transplant (HCT). Their performance on neurocognitive measures traditionally thought to measure white matter was compared to performance on measures thought to measure gray matter function. Composite white and gray matter standard scores were created based on neuropsychological measures that individuals with known white or gray matter damage perform poorly. As predicted, composite white matter scores (mean = 98.1) were significantly lower (t = 2.26, p = 0.03) than composite gray matter scores (mean = 102.5). Additionally, as gray matter performance increased, the difference between gray and white matter scores increased (R = 0.353, p = 0.035). Overall, the results of this study support the current theory that white matter damage is responsible for the more subtle neurocognitive late effects resulting from treatment for childhood leukemia.Keywords: late effects of cancer treatment, leukemia, neuropsychology, white matter, brain function Fiona S AndersonAlicia S Kunin-BatsonJoanna L PerkinsK Scott BakerDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2008, Iss Issue 1, Pp 283-288 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Fiona S Anderson Alicia S Kunin-Batson Joanna L Perkins K Scott Baker White versus gray matter function as seen on neuropsychological testing following bone marrow transplant for acute leukemia in childhood
description	Fiona S Anderson1, Alicia S Kunin-Batson1, Joanna L Perkins2, K Scott Baker31Divisions of Pediatric Clinical Neuroscience; 2Department of Pediatric Hematology/Oncology, Children&rsquo;s Hospitals and Clinics, Minneapolis, MN, USA and 3Hematology/Oncology/BMT, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USAAbstract: Current theory suggests that neurocognitive late effects of treatments for childhood cancer such as difficulties with attention, processing speed and visual-motor ability are the result of white matter damage. Neuroimaging studies have produced a variety of white matter findings. However, although white matter is thought to be differentially affected, previous studies have not demonstrated a discrepancy between white and gray matter function. The present study included 36 children treated for childhood leukemia with hematopoietic stem cell transplant (HCT). Their performance on neurocognitive measures traditionally thought to measure white matter was compared to performance on measures thought to measure gray matter function. Composite white and gray matter standard scores were created based on neuropsychological measures that individuals with known white or gray matter damage perform poorly. As predicted, composite white matter scores (mean = 98.1) were significantly lower (t = 2.26, p = 0.03) than composite gray matter scores (mean = 102.5). Additionally, as gray matter performance increased, the difference between gray and white matter scores increased (R = 0.353, p = 0.035). Overall, the results of this study support the current theory that white matter damage is responsible for the more subtle neurocognitive late effects resulting from treatment for childhood leukemia.Keywords: late effects of cancer treatment, leukemia, neuropsychology, white matter, brain function
format	article
author	Fiona S Anderson Alicia S Kunin-Batson Joanna L Perkins K Scott Baker
author_facet	Fiona S Anderson Alicia S Kunin-Batson Joanna L Perkins K Scott Baker
author_sort	Fiona S Anderson
title	White versus gray matter function as seen on neuropsychological testing following bone marrow transplant for acute leukemia in childhood
title_short	White versus gray matter function as seen on neuropsychological testing following bone marrow transplant for acute leukemia in childhood
title_full	White versus gray matter function as seen on neuropsychological testing following bone marrow transplant for acute leukemia in childhood
title_fullStr	White versus gray matter function as seen on neuropsychological testing following bone marrow transplant for acute leukemia in childhood
title_full_unstemmed	White versus gray matter function as seen on neuropsychological testing following bone marrow transplant for acute leukemia in childhood
title_sort	white versus gray matter function as seen on neuropsychological testing following bone marrow transplant for acute leukemia in childhood
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/44033395f1d64b7083317031f872a050
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White versus gray matter function as seen on neuropsychological testing following bone marrow transplant for acute leukemia in childhood

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