Dynamic roles of inflammasomes in inflammatory tumor microenvironment

Abstract The inflammatory tumor microenvironment has been known to be closely connected to all stages of cancer development, including initiation, promotion, and progression. Systemic inflammation in the tumor microenvironment is increasingly being recognized as an important prognostic marker in can...

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Autores principales:	Jeong-Hoon Jang, Do-Hee Kim, Young-Joon Surh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/44058df53ee64b9e9ccca7baa466d79c
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spelling	oai:doaj.org-article:44058df53ee64b9e9ccca7baa466d79c2021-12-02T13:28:25ZDynamic roles of inflammasomes in inflammatory tumor microenvironment10.1038/s41698-021-00154-72397-768Xhttps://doaj.org/article/44058df53ee64b9e9ccca7baa466d79c2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41698-021-00154-7https://doaj.org/toc/2397-768XAbstract The inflammatory tumor microenvironment has been known to be closely connected to all stages of cancer development, including initiation, promotion, and progression. Systemic inflammation in the tumor microenvironment is increasingly being recognized as an important prognostic marker in cancer patients. Inflammasomes are master regulators in the first line of host defense for the initiation of innate immune responses. Inflammasomes sense pathogen-associated molecular patterns and damage-associated molecular patterns, following recruitment of immune cells into infection sites. Therefore, dysregulated expression/activation of inflammasomes is implicated in pathogenesis of diverse inflammatory disorders. Recent studies have demonstrated that inflammasomes play a vital role in regulating the development and progression of cancer. This review focuses on fate-determining roles of the inflammasomes and the principal downstream effector cytokine, IL-1β, in the tumor microenvironment.Jeong-Hoon JangDo-Hee KimYoung-Joon SurhNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Precision Oncology, Vol 5, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Jeong-Hoon Jang Do-Hee Kim Young-Joon Surh Dynamic roles of inflammasomes in inflammatory tumor microenvironment
description	Abstract The inflammatory tumor microenvironment has been known to be closely connected to all stages of cancer development, including initiation, promotion, and progression. Systemic inflammation in the tumor microenvironment is increasingly being recognized as an important prognostic marker in cancer patients. Inflammasomes are master regulators in the first line of host defense for the initiation of innate immune responses. Inflammasomes sense pathogen-associated molecular patterns and damage-associated molecular patterns, following recruitment of immune cells into infection sites. Therefore, dysregulated expression/activation of inflammasomes is implicated in pathogenesis of diverse inflammatory disorders. Recent studies have demonstrated that inflammasomes play a vital role in regulating the development and progression of cancer. This review focuses on fate-determining roles of the inflammasomes and the principal downstream effector cytokine, IL-1β, in the tumor microenvironment.
format	article
author	Jeong-Hoon Jang Do-Hee Kim Young-Joon Surh
author_facet	Jeong-Hoon Jang Do-Hee Kim Young-Joon Surh
author_sort	Jeong-Hoon Jang
title	Dynamic roles of inflammasomes in inflammatory tumor microenvironment
title_short	Dynamic roles of inflammasomes in inflammatory tumor microenvironment
title_full	Dynamic roles of inflammasomes in inflammatory tumor microenvironment
title_fullStr	Dynamic roles of inflammasomes in inflammatory tumor microenvironment
title_full_unstemmed	Dynamic roles of inflammasomes in inflammatory tumor microenvironment
title_sort	dynamic roles of inflammasomes in inflammatory tumor microenvironment
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/44058df53ee64b9e9ccca7baa466d79c
work_keys_str_mv	AT jeonghoonjang dynamicrolesofinflammasomesininflammatorytumormicroenvironment AT doheekim dynamicrolesofinflammasomesininflammatorytumormicroenvironment AT youngjoonsurh dynamicrolesofinflammasomesininflammatorytumormicroenvironment
_version_	1718392971290738688

Dynamic roles of inflammasomes in inflammatory tumor microenvironment

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