Recent insights on nanomedicine for augmented infection control

Sima Singh,1,* Afzal Hussain,1,* Faiyaz Shakeel,2,* Mohamed Jawed Ahsan,3 Sultan Alshehri,2 Thomas J Webster,4,* Uma Ranjan Lal5 1Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Ranchi 835215, Jharkhand, India; 2Department of Pharmaceutics, College of Pharmacy,...

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Autores principales:	Singh S, Hussain A, Shakeel F, Ahsan MJ, Alshehri S, Webster TJ, Lal UR
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Nanomedicines Infection control Antimicrobial agents Drug Delivery Biosafety. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4406c4f47c1640368be916504579b881
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spelling	oai:doaj.org-article:4406c4f47c1640368be916504579b8812021-12-02T03:13:10ZRecent insights on nanomedicine for augmented infection control1178-2013https://doaj.org/article/4406c4f47c1640368be916504579b8812019-04-01T00:00:00Zhttps://www.dovepress.com/recent-insights-on-nanomedicine-for-augmented-infection-control-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Sima Singh,1,* Afzal Hussain,1,* Faiyaz Shakeel,2,* Mohamed Jawed Ahsan,3 Sultan Alshehri,2 Thomas J Webster,4,* Uma Ranjan Lal5 1Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Ranchi 835215, Jharkhand, India; 2Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia; 3Department of Pharmaceutical Chemistry, Maharishi Arvind College of Pharmacy, Jaipur, Rajasthan, 302023, India; 4Department of Chemical Engineering, Northeastern University, Boston, MA 02115, USA; 5School of Pharmaceutical Sciences, Shoolini University, Solan 173229, Himacahal Pradesh, India *These authors contributed equally to this work Abstract: Antimicrobial agents have been widely investigated for protecting against microbial infections in modern health. Drug-related limitations, poor bioavailability, toxicity to mammalian cells, and frequent bacteria drug resistance are major challenges faced when exploited in nanomedicine forms. Specific attention has been paid to control nanomaterial-based infection against numerous challenging pathogens in addition to improved drug delivery, targeting, and pharmacokinetic (PK) profiles, and thus, efficient antimicrobials have been fabricated using diverse components (metals, metal oxides, synthetic and semisynthetic polymers, natural or biodegradable polymers, etc). The present review covers several nanocarriers delivered through various routes of administration, highlighting major findings to control microbial infection as compared to using the free drug. Results over the past decade support the consistent development of various nanomedicines capable of improving biological significance and therapeutic benefits against an array of microbial strains. Depending on the intended application of nanomedicine, infection control will be challenged by various factors such as weighing the risk–benefits in healthcare settings, nanomaterial-induced (eco)toxicological hazards, frequent development of antibiotic resistance, scarcity of in vivo toxicity data, and a poor understanding of microbial interactions with nanomedicine at the molecular level. This review summarizes well-established informative data for nanomaterials used for infection control and safety concerns of nanomedicines to healthcare sectors followed by the significance of a unique “safe-by-design” approach. Keywords: recent nanomedicines, infection control, antimicrobial agents, drug delivery, biosafetySingh SHussain AShakeel FAhsan MJAlshehri SWebster TJLal URDove Medical PressarticleNanomedicinesInfection controlAntimicrobial agentsDrug DeliveryBiosafety.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 2301-2325 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Nanomedicines Infection control Antimicrobial agents Drug Delivery Biosafety. Medicine (General) R5-920
spellingShingle	Nanomedicines Infection control Antimicrobial agents Drug Delivery Biosafety. Medicine (General) R5-920 Singh S Hussain A Shakeel F Ahsan MJ Alshehri S Webster TJ Lal UR Recent insights on nanomedicine for augmented infection control
description	Sima Singh,1,* Afzal Hussain,1,* Faiyaz Shakeel,2,* Mohamed Jawed Ahsan,3 Sultan Alshehri,2 Thomas J Webster,4,* Uma Ranjan Lal5 1Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Ranchi 835215, Jharkhand, India; 2Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia; 3Department of Pharmaceutical Chemistry, Maharishi Arvind College of Pharmacy, Jaipur, Rajasthan, 302023, India; 4Department of Chemical Engineering, Northeastern University, Boston, MA 02115, USA; 5School of Pharmaceutical Sciences, Shoolini University, Solan 173229, Himacahal Pradesh, India *These authors contributed equally to this work Abstract: Antimicrobial agents have been widely investigated for protecting against microbial infections in modern health. Drug-related limitations, poor bioavailability, toxicity to mammalian cells, and frequent bacteria drug resistance are major challenges faced when exploited in nanomedicine forms. Specific attention has been paid to control nanomaterial-based infection against numerous challenging pathogens in addition to improved drug delivery, targeting, and pharmacokinetic (PK) profiles, and thus, efficient antimicrobials have been fabricated using diverse components (metals, metal oxides, synthetic and semisynthetic polymers, natural or biodegradable polymers, etc). The present review covers several nanocarriers delivered through various routes of administration, highlighting major findings to control microbial infection as compared to using the free drug. Results over the past decade support the consistent development of various nanomedicines capable of improving biological significance and therapeutic benefits against an array of microbial strains. Depending on the intended application of nanomedicine, infection control will be challenged by various factors such as weighing the risk–benefits in healthcare settings, nanomaterial-induced (eco)toxicological hazards, frequent development of antibiotic resistance, scarcity of in vivo toxicity data, and a poor understanding of microbial interactions with nanomedicine at the molecular level. This review summarizes well-established informative data for nanomaterials used for infection control and safety concerns of nanomedicines to healthcare sectors followed by the significance of a unique “safe-by-design” approach. Keywords: recent nanomedicines, infection control, antimicrobial agents, drug delivery, biosafety
format	article
author	Singh S Hussain A Shakeel F Ahsan MJ Alshehri S Webster TJ Lal UR
author_facet	Singh S Hussain A Shakeel F Ahsan MJ Alshehri S Webster TJ Lal UR
author_sort	Singh S
title	Recent insights on nanomedicine for augmented infection control
title_short	Recent insights on nanomedicine for augmented infection control
title_full	Recent insights on nanomedicine for augmented infection control
title_fullStr	Recent insights on nanomedicine for augmented infection control
title_full_unstemmed	Recent insights on nanomedicine for augmented infection control
title_sort	recent insights on nanomedicine for augmented infection control
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/4406c4f47c1640368be916504579b881
work_keys_str_mv	AT singhs recentinsightsonnanomedicineforaugmentedinfectioncontrol AT hussaina recentinsightsonnanomedicineforaugmentedinfectioncontrol AT shakeelf recentinsightsonnanomedicineforaugmentedinfectioncontrol AT ahsanmj recentinsightsonnanomedicineforaugmentedinfectioncontrol AT alshehris recentinsightsonnanomedicineforaugmentedinfectioncontrol AT webstertj recentinsightsonnanomedicineforaugmentedinfectioncontrol AT lalur recentinsightsonnanomedicineforaugmentedinfectioncontrol
_version_	1718401848641060864

Recent insights on nanomedicine for augmented infection control

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