Psoriasis and Cardiometabolic Diseases: The Impact of Inflammation on Vascular Health

Meron Teklu, Philip M Parel, Nehal N Mehta National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USACorrespondence: Nehal N MehtaLasker Senior Investigator, Chief, Section of Inflammation and Cardiometabolic Diseases, National Heart, Lung and Blood Institute, Nation...

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Autores principales:	Teklu M, Parel PM, Mehta NN
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	psoriasis inflammation metabolic syndrome atherosclerosis Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/4409475cc7bb458088cfff6be20c97bf
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spelling	oai:doaj.org-article:4409475cc7bb458088cfff6be20c97bf2021-12-02T16:43:13ZPsoriasis and Cardiometabolic Diseases: The Impact of Inflammation on Vascular Health2230-326Xhttps://doaj.org/article/4409475cc7bb458088cfff6be20c97bf2021-07-01T00:00:00Zhttps://www.dovepress.com/psoriasis-and-cardiometabolic-diseases-the-impact-of-inflammation-on-v-peer-reviewed-fulltext-article-PTThttps://doaj.org/toc/2230-326XMeron Teklu, Philip M Parel, Nehal N Mehta National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USACorrespondence: Nehal N MehtaLasker Senior Investigator, Chief, Section of Inflammation and Cardiometabolic Diseases, National Heart, Lung and Blood Institute, National Institutes of Health, 10 Center Drive, Clinical Research Center, Room 5-5140, Bethesda, MD, 20892, USATel +1-301-827-0483Fax +1-301-827-0915Email nehal.mehta@nih.govAbstract: Psoriasis is a common chronic inflammatory condition associated with a higher risk of cardiovascular disease. Psoriasis confers a dose-dependent increase in risk for the metabolic syndrome and its components. The metabolic syndrome and its components have been associated with higher coronary atherosclerosis in psoriasis and cardiovascular events in the general population. In this review, we discuss the role of inflammation and psoriasis in cardiometabolic diseases with a focus on the metabolic syndrome and its components. We highlight the relationship between psoriasis and important cardiovascular risk factors encompassed by obesity, dyslipidemia, insulin resistance and hypertension. Furthermore, we briefly highlight literature on anti-inflammatory therapies and their impact on the components of the metabolic syndrome as well as directly quantified coronary atherosclerosis burden.Keywords: psoriasis, inflammation, metabolic syndrome, atherosclerosisTeklu MParel PMMehta NNDove Medical Pressarticlepsoriasisinflammationmetabolic syndromeatherosclerosisDermatologyRL1-803ENPsoriasis: Targets and Therapy, Vol Volume 11, Pp 99-108 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	psoriasis inflammation metabolic syndrome atherosclerosis Dermatology RL1-803
spellingShingle	psoriasis inflammation metabolic syndrome atherosclerosis Dermatology RL1-803 Teklu M Parel PM Mehta NN Psoriasis and Cardiometabolic Diseases: The Impact of Inflammation on Vascular Health
description	Meron Teklu, Philip M Parel, Nehal N Mehta National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USACorrespondence: Nehal N MehtaLasker Senior Investigator, Chief, Section of Inflammation and Cardiometabolic Diseases, National Heart, Lung and Blood Institute, National Institutes of Health, 10 Center Drive, Clinical Research Center, Room 5-5140, Bethesda, MD, 20892, USATel +1-301-827-0483Fax +1-301-827-0915Email nehal.mehta@nih.govAbstract: Psoriasis is a common chronic inflammatory condition associated with a higher risk of cardiovascular disease. Psoriasis confers a dose-dependent increase in risk for the metabolic syndrome and its components. The metabolic syndrome and its components have been associated with higher coronary atherosclerosis in psoriasis and cardiovascular events in the general population. In this review, we discuss the role of inflammation and psoriasis in cardiometabolic diseases with a focus on the metabolic syndrome and its components. We highlight the relationship between psoriasis and important cardiovascular risk factors encompassed by obesity, dyslipidemia, insulin resistance and hypertension. Furthermore, we briefly highlight literature on anti-inflammatory therapies and their impact on the components of the metabolic syndrome as well as directly quantified coronary atherosclerosis burden.Keywords: psoriasis, inflammation, metabolic syndrome, atherosclerosis
format	article
author	Teklu M Parel PM Mehta NN
author_facet	Teklu M Parel PM Mehta NN
author_sort	Teklu M
title	Psoriasis and Cardiometabolic Diseases: The Impact of Inflammation on Vascular Health
title_short	Psoriasis and Cardiometabolic Diseases: The Impact of Inflammation on Vascular Health
title_full	Psoriasis and Cardiometabolic Diseases: The Impact of Inflammation on Vascular Health
title_fullStr	Psoriasis and Cardiometabolic Diseases: The Impact of Inflammation on Vascular Health
title_full_unstemmed	Psoriasis and Cardiometabolic Diseases: The Impact of Inflammation on Vascular Health
title_sort	psoriasis and cardiometabolic diseases: the impact of inflammation on vascular health
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/4409475cc7bb458088cfff6be20c97bf
work_keys_str_mv	AT teklum psoriasisandcardiometabolicdiseasestheimpactofinflammationonvascularhealth AT parelpm psoriasisandcardiometabolicdiseasestheimpactofinflammationonvascularhealth AT mehtann psoriasisandcardiometabolicdiseasestheimpactofinflammationonvascularhealth
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Psoriasis and Cardiometabolic Diseases: The Impact of Inflammation on Vascular Health

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