Numerical prediction of drug release from polyurethane samples combining kinetic model developed by experimental data

With the aim of optimizing Drug Eluting Stents (DES), particular attention has been laid on computational methods of controlling the drug release profile among researchers. Consequently, various models and simulations are available in the literature. Nevertheless, validations based on biorelevant in...

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Autores principales:	Song Jianfei, Abbasnezhad Navideh, Specklin Mathieu, Shirinbayan Mohammadali, Kouidri Smaine, Bakir Farid
Formato:	article
Lenguaje:	EN FR
Publicado:	EDP Sciences 2021
Materias:	Environmental sciences GE1-350
Acceso en línea:	https://doaj.org/article/440a5d1f890a4b97822c4f9239dd43fe
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spelling	oai:doaj.org-article:440a5d1f890a4b97822c4f9239dd43fe2021-11-12T11:44:34ZNumerical prediction of drug release from polyurethane samples combining kinetic model developed by experimental data2267-124210.1051/e3sconf/202132103012https://doaj.org/article/440a5d1f890a4b97822c4f9239dd43fe2021-01-01T00:00:00Zhttps://www.e3s-conferences.org/articles/e3sconf/pdf/2021/97/e3sconf_icchmt2021_03012.pdfhttps://doaj.org/toc/2267-1242With the aim of optimizing Drug Eluting Stents (DES), particular attention has been laid on computational methods of controlling the drug release profile among researchers. Consequently, various models and simulations are available in the literature. Nevertheless, validations based on biorelevant in-vitro trials are lacking. In the present study, a comparison of drug release from polyurethane samples between calculated results and experimental-data has been carried out. The calculation results are from a numerical simulation and a newly established mathematical model for reproducing the liberation kinetic. Different fluid flow rates and initial drug concentrations in polymer have been taken into account.Song JianfeiAbbasnezhad NavidehSpecklin MathieuShirinbayan MohammadaliKouidri SmaineBakir FaridEDP SciencesarticleEnvironmental sciencesGE1-350ENFRE3S Web of Conferences, Vol 321, p 03012 (2021)
institution	DOAJ
collection	DOAJ
language	EN FR
topic	Environmental sciences GE1-350
spellingShingle	Environmental sciences GE1-350 Song Jianfei Abbasnezhad Navideh Specklin Mathieu Shirinbayan Mohammadali Kouidri Smaine Bakir Farid Numerical prediction of drug release from polyurethane samples combining kinetic model developed by experimental data
description	With the aim of optimizing Drug Eluting Stents (DES), particular attention has been laid on computational methods of controlling the drug release profile among researchers. Consequently, various models and simulations are available in the literature. Nevertheless, validations based on biorelevant in-vitro trials are lacking. In the present study, a comparison of drug release from polyurethane samples between calculated results and experimental-data has been carried out. The calculation results are from a numerical simulation and a newly established mathematical model for reproducing the liberation kinetic. Different fluid flow rates and initial drug concentrations in polymer have been taken into account.
format	article
author	Song Jianfei Abbasnezhad Navideh Specklin Mathieu Shirinbayan Mohammadali Kouidri Smaine Bakir Farid
author_facet	Song Jianfei Abbasnezhad Navideh Specklin Mathieu Shirinbayan Mohammadali Kouidri Smaine Bakir Farid
author_sort	Song Jianfei
title	Numerical prediction of drug release from polyurethane samples combining kinetic model developed by experimental data
title_short	Numerical prediction of drug release from polyurethane samples combining kinetic model developed by experimental data
title_full	Numerical prediction of drug release from polyurethane samples combining kinetic model developed by experimental data
title_fullStr	Numerical prediction of drug release from polyurethane samples combining kinetic model developed by experimental data
title_full_unstemmed	Numerical prediction of drug release from polyurethane samples combining kinetic model developed by experimental data
title_sort	numerical prediction of drug release from polyurethane samples combining kinetic model developed by experimental data
publisher	EDP Sciences
publishDate	2021
url	https://doaj.org/article/440a5d1f890a4b97822c4f9239dd43fe
work_keys_str_mv	AT songjianfei numericalpredictionofdrugreleasefrompolyurethanesamplescombiningkineticmodeldevelopedbyexperimentaldata AT abbasnezhadnavideh numericalpredictionofdrugreleasefrompolyurethanesamplescombiningkineticmodeldevelopedbyexperimentaldata AT specklinmathieu numericalpredictionofdrugreleasefrompolyurethanesamplescombiningkineticmodeldevelopedbyexperimentaldata AT shirinbayanmohammadali numericalpredictionofdrugreleasefrompolyurethanesamplescombiningkineticmodeldevelopedbyexperimentaldata AT kouidrismaine numericalpredictionofdrugreleasefrompolyurethanesamplescombiningkineticmodeldevelopedbyexperimentaldata AT bakirfarid numericalpredictionofdrugreleasefrompolyurethanesamplescombiningkineticmodeldevelopedbyexperimentaldata
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Numerical prediction of drug release from polyurethane samples combining kinetic model developed by experimental data

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