Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis

Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis

The mechanisms underlying pre-metastatic niche formation by cancer derived exosomes is unclear. Here they show that colorectal cancer (CRC) derived exosomal miR-25-3p promotes vascular leakiness and angiogenesis, CRC metastasis, and is upregulated in CRC pateints with metastasis, and suggest miR-25-...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Zhicheng Zeng, Yuling Li, Yangjian Pan, Xiaoliang Lan, Fuyao Song, Jingbo Sun, Kun Zhou, Xiaolong Liu, Xiaoli Ren, Feifei Wang, Jinlong Hu, Xiaohui Zhu, Wei Yang, Wenting Liao, Guoxin Li, Yanqing Ding, Li Liang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/440ea86ff3134162b4e58720f16eab38
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:440ea86ff3134162b4e58720f16eab38
record_format dspace
spelling oai:doaj.org-article:440ea86ff3134162b4e58720f16eab382021-12-02T14:39:26ZCancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis10.1038/s41467-018-07810-w2041-1723https://doaj.org/article/440ea86ff3134162b4e58720f16eab382018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07810-whttps://doaj.org/toc/2041-1723The mechanisms underlying pre-metastatic niche formation by cancer derived exosomes is unclear. Here they show that colorectal cancer (CRC) derived exosomal miR-25-3p promotes vascular leakiness and angiogenesis, CRC metastasis, and is upregulated in CRC pateints with metastasis, and suggest miR-25-3p as a biomarker for CRC metastasis.Zhicheng ZengYuling LiYangjian PanXiaoliang LanFuyao SongJingbo SunKun ZhouXiaolong LiuXiaoli RenFeifei WangJinlong HuXiaohui ZhuWei YangWenting LiaoGuoxin LiYanqing DingLi LiangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Zhicheng Zeng
Yuling Li
Yangjian Pan
Xiaoliang Lan
Fuyao Song
Jingbo Sun
Kun Zhou
Xiaolong Liu
Xiaoli Ren
Feifei Wang
Jinlong Hu
Xiaohui Zhu
Wei Yang
Wenting Liao
Guoxin Li
Yanqing Ding
Li Liang
Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis
description The mechanisms underlying pre-metastatic niche formation by cancer derived exosomes is unclear. Here they show that colorectal cancer (CRC) derived exosomal miR-25-3p promotes vascular leakiness and angiogenesis, CRC metastasis, and is upregulated in CRC pateints with metastasis, and suggest miR-25-3p as a biomarker for CRC metastasis.
format article
author Zhicheng Zeng
Yuling Li
Yangjian Pan
Xiaoliang Lan
Fuyao Song
Jingbo Sun
Kun Zhou
Xiaolong Liu
Xiaoli Ren
Feifei Wang
Jinlong Hu
Xiaohui Zhu
Wei Yang
Wenting Liao
Guoxin Li
Yanqing Ding
Li Liang
author_facet Zhicheng Zeng
Yuling Li
Yangjian Pan
Xiaoliang Lan
Fuyao Song
Jingbo Sun
Kun Zhou
Xiaolong Liu
Xiaoli Ren
Feifei Wang
Jinlong Hu
Xiaohui Zhu
Wei Yang
Wenting Liao
Guoxin Li
Yanqing Ding
Li Liang
author_sort Zhicheng Zeng
title Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis
title_short Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis
title_full Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis
title_fullStr Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis
title_full_unstemmed Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis
title_sort cancer-derived exosomal mir-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/440ea86ff3134162b4e58720f16eab38
work_keys_str_mv AT zhichengzeng cancerderivedexosomalmir253ppromotespremetastaticnicheformationbyinducingvascularpermeabilityandangiogenesis
AT yulingli cancerderivedexosomalmir253ppromotespremetastaticnicheformationbyinducingvascularpermeabilityandangiogenesis
AT yangjianpan cancerderivedexosomalmir253ppromotespremetastaticnicheformationbyinducingvascularpermeabilityandangiogenesis
AT xiaolianglan cancerderivedexosomalmir253ppromotespremetastaticnicheformationbyinducingvascularpermeabilityandangiogenesis
AT fuyaosong cancerderivedexosomalmir253ppromotespremetastaticnicheformationbyinducingvascularpermeabilityandangiogenesis
AT jingbosun cancerderivedexosomalmir253ppromotespremetastaticnicheformationbyinducingvascularpermeabilityandangiogenesis
AT kunzhou cancerderivedexosomalmir253ppromotespremetastaticnicheformationbyinducingvascularpermeabilityandangiogenesis
AT xiaolongliu cancerderivedexosomalmir253ppromotespremetastaticnicheformationbyinducingvascularpermeabilityandangiogenesis
AT xiaoliren cancerderivedexosomalmir253ppromotespremetastaticnicheformationbyinducingvascularpermeabilityandangiogenesis
AT feifeiwang cancerderivedexosomalmir253ppromotespremetastaticnicheformationbyinducingvascularpermeabilityandangiogenesis
AT jinlonghu cancerderivedexosomalmir253ppromotespremetastaticnicheformationbyinducingvascularpermeabilityandangiogenesis
AT xiaohuizhu cancerderivedexosomalmir253ppromotespremetastaticnicheformationbyinducingvascularpermeabilityandangiogenesis
AT weiyang cancerderivedexosomalmir253ppromotespremetastaticnicheformationbyinducingvascularpermeabilityandangiogenesis
AT wentingliao cancerderivedexosomalmir253ppromotespremetastaticnicheformationbyinducingvascularpermeabilityandangiogenesis
AT guoxinli cancerderivedexosomalmir253ppromotespremetastaticnicheformationbyinducingvascularpermeabilityandangiogenesis
AT yanqingding cancerderivedexosomalmir253ppromotespremetastaticnicheformationbyinducingvascularpermeabilityandangiogenesis
AT liliang cancerderivedexosomalmir253ppromotespremetastaticnicheformationbyinducingvascularpermeabilityandangiogenesis
_version_ 1718390586842546176

Ejemplares similares