Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis

Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis

The mechanisms underlying pre-metastatic niche formation by cancer derived exosomes is unclear. Here they show that colorectal cancer (CRC) derived exosomal miR-25-3p promotes vascular leakiness and angiogenesis, CRC metastasis, and is upregulated in CRC pateints with metastasis, and suggest miR-25-...

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Bibliographic Details
Main Authors: Zhicheng Zeng, Yuling Li, Yangjian Pan, Xiaoliang Lan, Fuyao Song, Jingbo Sun, Kun Zhou, Xiaolong Liu, Xiaoli Ren, Feifei Wang, Jinlong Hu, Xiaohui Zhu, Wei Yang, Wenting Liao, Guoxin Li, Yanqing Ding, Li Liang
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Science
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Online Access:https://doaj.org/article/440ea86ff3134162b4e58720f16eab38
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