Chemokines and Innate Lymphoid Cells in Skin Inflammation

As the outermost barrier, skin plays an important role in protecting our bodies against outside invasion. Under stable conditions or during inflammation, leukocytes migration is essential for restoring homeostasis in the skin. Immune cells trafficking is orchestrated by chemokines; leukocytes expres...

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Autores principales:	Zhengwang Sun, Ravi Vattepu, Songfa Zhang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	chemokines innate lymphoid cells skin contact hypersensitivity atopic dermatitis psoriasis Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/440f7bc1295d4bc3aee03df229d01a0a
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id	oai:doaj.org-article:440f7bc1295d4bc3aee03df229d01a0a
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spelling	oai:doaj.org-article:440f7bc1295d4bc3aee03df229d01a0a2021-11-25T17:11:14ZChemokines and Innate Lymphoid Cells in Skin Inflammation10.3390/cells101130742073-4409https://doaj.org/article/440f7bc1295d4bc3aee03df229d01a0a2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3074https://doaj.org/toc/2073-4409As the outermost barrier, skin plays an important role in protecting our bodies against outside invasion. Under stable conditions or during inflammation, leukocytes migration is essential for restoring homeostasis in the skin. Immune cells trafficking is orchestrated by chemokines; leukocytes express receptors that bind to chemokines and trigger migration. The homeostasis of the immune ecosystem is an extremely complicated dynamic process that requires the cooperation of innate and adaptive immune cells. Emerging studies have been shedding a light on the unique characteristics of skin-resident innate lymphoid cells (ILCs). In this review, we discuss how chemokines orchestrate skin ILCs trafficking and contribute to tissue homeostasis and how abnormal chemokine–chemokine receptor interactions contribute to and augment skin inflammation, as seen in conditions such as contact hypersensitivity, atopic dermatitis, and psoriasis.Zhengwang SunRavi VattepuSongfa ZhangMDPI AGarticlechemokinesinnate lymphoid cellsskincontact hypersensitivityatopic dermatitispsoriasisBiology (General)QH301-705.5ENCells, Vol 10, Iss 3074, p 3074 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chemokines innate lymphoid cells skin contact hypersensitivity atopic dermatitis psoriasis Biology (General) QH301-705.5
spellingShingle	chemokines innate lymphoid cells skin contact hypersensitivity atopic dermatitis psoriasis Biology (General) QH301-705.5 Zhengwang Sun Ravi Vattepu Songfa Zhang Chemokines and Innate Lymphoid Cells in Skin Inflammation
description	As the outermost barrier, skin plays an important role in protecting our bodies against outside invasion. Under stable conditions or during inflammation, leukocytes migration is essential for restoring homeostasis in the skin. Immune cells trafficking is orchestrated by chemokines; leukocytes express receptors that bind to chemokines and trigger migration. The homeostasis of the immune ecosystem is an extremely complicated dynamic process that requires the cooperation of innate and adaptive immune cells. Emerging studies have been shedding a light on the unique characteristics of skin-resident innate lymphoid cells (ILCs). In this review, we discuss how chemokines orchestrate skin ILCs trafficking and contribute to tissue homeostasis and how abnormal chemokine–chemokine receptor interactions contribute to and augment skin inflammation, as seen in conditions such as contact hypersensitivity, atopic dermatitis, and psoriasis.
format	article
author	Zhengwang Sun Ravi Vattepu Songfa Zhang
author_facet	Zhengwang Sun Ravi Vattepu Songfa Zhang
author_sort	Zhengwang Sun
title	Chemokines and Innate Lymphoid Cells in Skin Inflammation
title_short	Chemokines and Innate Lymphoid Cells in Skin Inflammation
title_full	Chemokines and Innate Lymphoid Cells in Skin Inflammation
title_fullStr	Chemokines and Innate Lymphoid Cells in Skin Inflammation
title_full_unstemmed	Chemokines and Innate Lymphoid Cells in Skin Inflammation
title_sort	chemokines and innate lymphoid cells in skin inflammation
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/440f7bc1295d4bc3aee03df229d01a0a
work_keys_str_mv	AT zhengwangsun chemokinesandinnatelymphoidcellsinskininflammation AT ravivattepu chemokinesandinnatelymphoidcellsinskininflammation AT songfazhang chemokinesandinnatelymphoidcellsinskininflammation
_version_	1718412644510072832

Chemokines and Innate Lymphoid Cells in Skin Inflammation

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