RhoGAP domain-containing fusions and PPAPDC1A fusions are recurrent and prognostic in diffuse gastric cancer

RhoGAP domain-containing fusions and PPAPDC1A fusions are recurrent and prognostic in diffuse gastric cancer

Diffuse Gastric Cancer (DGC) is increasingly being considered separate to intestinal type gastric cancer; several fusions events have been reported as drivers of the disease but few of those have been subsequently validated. Here the authors perform RNA-seq on early-onset DGC patients who had not be...

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Autores principales: Hanna Yang, Dongwan Hong, Soo Young Cho, Young Soo Park, Woo Ri Ko, Ju Hee Kim, Hoon Hur, Jongkeun Lee, Su-Jin Kim, Sun Young Kwon, Jae-Hyuk Lee, Do Youn Park, Kyu Sang Song, Heekyung Chang, Min-Hee Ryu, Kye Soo Cho, Jeong Won Kang, Myeong-Cherl Kook, Nina Thiessen, An He, Andy Mungall, Sang-Uk Han, Hark Kyun Kim
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Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/4413357147b1453f93722e061ea66743
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spelling oai:doaj.org-article:4413357147b1453f93722e061ea667432021-12-02T16:49:53ZRhoGAP domain-containing fusions and PPAPDC1A fusions are recurrent and prognostic in diffuse gastric cancer10.1038/s41467-018-06747-42041-1723https://doaj.org/article/4413357147b1453f93722e061ea667432018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06747-4https://doaj.org/toc/2041-1723Diffuse Gastric Cancer (DGC) is increasingly being considered separate to intestinal type gastric cancer; several fusions events have been reported as drivers of the disease but few of those have been subsequently validated. Here the authors perform RNA-seq on early-onset DGC patients who had not been treated with chemotherapy or radiation and identify a previously unknown fusion.Hanna YangDongwan HongSoo Young ChoYoung Soo ParkWoo Ri KoJu Hee KimHoon HurJongkeun LeeSu-Jin KimSun Young KwonJae-Hyuk LeeDo Youn ParkKyu Sang SongHeekyung ChangMin-Hee RyuKye Soo ChoJeong Won KangMyeong-Cherl KookNina ThiessenAn HeAndy MungallSang-Uk HanHark Kyun KimNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Hanna Yang
Dongwan Hong
Soo Young Cho
Young Soo Park
Woo Ri Ko
Ju Hee Kim
Hoon Hur
Jongkeun Lee
Su-Jin Kim
Sun Young Kwon
Jae-Hyuk Lee
Do Youn Park
Kyu Sang Song
Heekyung Chang
Min-Hee Ryu
Kye Soo Cho
Jeong Won Kang
Myeong-Cherl Kook
Nina Thiessen
An He
Andy Mungall
Sang-Uk Han
Hark Kyun Kim
RhoGAP domain-containing fusions and PPAPDC1A fusions are recurrent and prognostic in diffuse gastric cancer
description Diffuse Gastric Cancer (DGC) is increasingly being considered separate to intestinal type gastric cancer; several fusions events have been reported as drivers of the disease but few of those have been subsequently validated. Here the authors perform RNA-seq on early-onset DGC patients who had not been treated with chemotherapy or radiation and identify a previously unknown fusion.
format article
author Hanna Yang
Dongwan Hong
Soo Young Cho
Young Soo Park
Woo Ri Ko
Ju Hee Kim
Hoon Hur
Jongkeun Lee
Su-Jin Kim
Sun Young Kwon
Jae-Hyuk Lee
Do Youn Park
Kyu Sang Song
Heekyung Chang
Min-Hee Ryu
Kye Soo Cho
Jeong Won Kang
Myeong-Cherl Kook
Nina Thiessen
An He
Andy Mungall
Sang-Uk Han
Hark Kyun Kim
author_facet Hanna Yang
Dongwan Hong
Soo Young Cho
Young Soo Park
Woo Ri Ko
Ju Hee Kim
Hoon Hur
Jongkeun Lee
Su-Jin Kim
Sun Young Kwon
Jae-Hyuk Lee
Do Youn Park
Kyu Sang Song
Heekyung Chang
Min-Hee Ryu
Kye Soo Cho
Jeong Won Kang
Myeong-Cherl Kook
Nina Thiessen
An He
Andy Mungall
Sang-Uk Han
Hark Kyun Kim
author_sort Hanna Yang
title RhoGAP domain-containing fusions and PPAPDC1A fusions are recurrent and prognostic in diffuse gastric cancer
title_short RhoGAP domain-containing fusions and PPAPDC1A fusions are recurrent and prognostic in diffuse gastric cancer
title_full RhoGAP domain-containing fusions and PPAPDC1A fusions are recurrent and prognostic in diffuse gastric cancer
title_fullStr RhoGAP domain-containing fusions and PPAPDC1A fusions are recurrent and prognostic in diffuse gastric cancer
title_full_unstemmed RhoGAP domain-containing fusions and PPAPDC1A fusions are recurrent and prognostic in diffuse gastric cancer
title_sort rhogap domain-containing fusions and ppapdc1a fusions are recurrent and prognostic in diffuse gastric cancer
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/4413357147b1453f93722e061ea66743
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