Hepatocyte mitochondria-derived danger signals directly activate hepatic stellate cells and drive progression of liver fibrosis

Progressive fibrosis is a driver of morbidity and mortality in many chronic liver diseases, but the underlying mechanisms are incompletely understood. Here, the authors show that mitochondria-derived damage-associated molecular patterns are released from injured hepatocytes and can trigger fibrogeni...

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Autores principales:	Ping An, Lin-Lin Wei, Shuangshuang Zhao, Deanna Y. Sverdlov, Kahini A. Vaid, Makoto Miyamoto, Kaori Kuramitsu, Michelle Lai, Yury V. Popov
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/44134943fce4419c97cee7871e6d7d2d
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spelling	oai:doaj.org-article:44134943fce4419c97cee7871e6d7d2d2021-12-02T16:50:20ZHepatocyte mitochondria-derived danger signals directly activate hepatic stellate cells and drive progression of liver fibrosis10.1038/s41467-020-16092-02041-1723https://doaj.org/article/44134943fce4419c97cee7871e6d7d2d2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16092-0https://doaj.org/toc/2041-1723Progressive fibrosis is a driver of morbidity and mortality in many chronic liver diseases, but the underlying mechanisms are incompletely understood. Here, the authors show that mitochondria-derived damage-associated molecular patterns are released from injured hepatocytes and can trigger fibrogenic activation of hepatic stellate cells.Ping AnLin-Lin WeiShuangshuang ZhaoDeanna Y. SverdlovKahini A. VaidMakoto MiyamotoKaori KuramitsuMichelle LaiYury V. PopovNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ping An Lin-Lin Wei Shuangshuang Zhao Deanna Y. Sverdlov Kahini A. Vaid Makoto Miyamoto Kaori Kuramitsu Michelle Lai Yury V. Popov Hepatocyte mitochondria-derived danger signals directly activate hepatic stellate cells and drive progression of liver fibrosis
description	Progressive fibrosis is a driver of morbidity and mortality in many chronic liver diseases, but the underlying mechanisms are incompletely understood. Here, the authors show that mitochondria-derived damage-associated molecular patterns are released from injured hepatocytes and can trigger fibrogenic activation of hepatic stellate cells.
format	article
author	Ping An Lin-Lin Wei Shuangshuang Zhao Deanna Y. Sverdlov Kahini A. Vaid Makoto Miyamoto Kaori Kuramitsu Michelle Lai Yury V. Popov
author_facet	Ping An Lin-Lin Wei Shuangshuang Zhao Deanna Y. Sverdlov Kahini A. Vaid Makoto Miyamoto Kaori Kuramitsu Michelle Lai Yury V. Popov
author_sort	Ping An
title	Hepatocyte mitochondria-derived danger signals directly activate hepatic stellate cells and drive progression of liver fibrosis
title_short	Hepatocyte mitochondria-derived danger signals directly activate hepatic stellate cells and drive progression of liver fibrosis
title_full	Hepatocyte mitochondria-derived danger signals directly activate hepatic stellate cells and drive progression of liver fibrosis
title_fullStr	Hepatocyte mitochondria-derived danger signals directly activate hepatic stellate cells and drive progression of liver fibrosis
title_full_unstemmed	Hepatocyte mitochondria-derived danger signals directly activate hepatic stellate cells and drive progression of liver fibrosis
title_sort	hepatocyte mitochondria-derived danger signals directly activate hepatic stellate cells and drive progression of liver fibrosis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/44134943fce4419c97cee7871e6d7d2d
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Hepatocyte mitochondria-derived danger signals directly activate hepatic stellate cells and drive progression of liver fibrosis

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