Gut Microbiota in the First 2 Years of Life and the Association with Body Mass Index at Age 12 in a Norwegian Birth Cohort

ABSTRACT Childhood obesity is a growing problem worldwide. Recent research suggests that the gut microbiota may play an important and potentially causal role in the development of obesity and may be one mechanism that explains the transgenerational transmission of obesity risk. Here we examine the e...

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Autores principales:	Maggie A. Stanislawski, Dana Dabelea, Brandie D. Wagner, Nina Iszatt, Cecilie Dahl, Marci K. Sontag, Rob Knight, Catherine A. Lozupone, Merete Eggesbø
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	children infants microbiota obesity Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/4413fc1cd7bb46d08c1f93301fb05a81
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spelling	oai:doaj.org-article:4413fc1cd7bb46d08c1f93301fb05a812021-11-15T15:58:20ZGut Microbiota in the First 2 Years of Life and the Association with Body Mass Index at Age 12 in a Norwegian Birth Cohort10.1128/mBio.01751-182150-7511https://doaj.org/article/4413fc1cd7bb46d08c1f93301fb05a812018-11-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01751-18https://doaj.org/toc/2150-7511ABSTRACT Childhood obesity is a growing problem worldwide. Recent research suggests that the gut microbiota may play an important and potentially causal role in the development of obesity and may be one mechanism that explains the transgenerational transmission of obesity risk. Here we examine the early-life gut microbiota at days 4, 10, 30, 120, 365, and 730 and the association with body mass index (BMI) z-scores at age 12 in a Norwegian prospective cohort (n = 165), and evaluate how these BMI-associated taxa relate to maternal overweight/obesity (Ow/Ob) and excessive gestational weight gain (GWG). We performed 16S rRNA gene sequencing on the gut microbiota samples. Taxonomic phylogeny at days 10 and 730 was significantly associated with childhood BMI, and the gut microbiota taxa at two years of age explained over 50% of the variation in childhood BMI in this cohort. The subset of the early-life taxa within the gut microbiota that best predicted later childhood BMI showed substantial overlap with the maternal taxa most strongly associated with maternal Ow/Ob and excessive GWG. Our results show an association between the infant gut microbiota and later BMI, and they offer preliminary evidence that the infant gut microbiota, particularly at 2 years of age, may have potential to help identify children at risk for obesity. IMPORTANCE Understanding the role of the early-life gut microbiota in obesity is important because there may be opportunities for preventive strategies. We examined the relationships between infant gut microbiota at six times during the first two years of life and BMI at age 12 in a birth cohort of 165 children and their mothers. We found that the gut microbiota from early life to two years shows an increasingly strong association with childhood BMI. This study provides preliminary evidence that the gut microbiome at 2 years of age may offer useful information to help to identify youth who are at risk for obesity, which could facilitate more-targeted early prevention efforts.Maggie A. StanislawskiDana DabeleaBrandie D. WagnerNina IszattCecilie DahlMarci K. SontagRob KnightCatherine A. LozuponeMerete EggesbøAmerican Society for MicrobiologyarticlechildreninfantsmicrobiotaobesityMicrobiologyQR1-502ENmBio, Vol 9, Iss 5 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	children infants microbiota obesity Microbiology QR1-502
spellingShingle	children infants microbiota obesity Microbiology QR1-502 Maggie A. Stanislawski Dana Dabelea Brandie D. Wagner Nina Iszatt Cecilie Dahl Marci K. Sontag Rob Knight Catherine A. Lozupone Merete Eggesbø Gut Microbiota in the First 2 Years of Life and the Association with Body Mass Index at Age 12 in a Norwegian Birth Cohort
description	ABSTRACT Childhood obesity is a growing problem worldwide. Recent research suggests that the gut microbiota may play an important and potentially causal role in the development of obesity and may be one mechanism that explains the transgenerational transmission of obesity risk. Here we examine the early-life gut microbiota at days 4, 10, 30, 120, 365, and 730 and the association with body mass index (BMI) z-scores at age 12 in a Norwegian prospective cohort (n = 165), and evaluate how these BMI-associated taxa relate to maternal overweight/obesity (Ow/Ob) and excessive gestational weight gain (GWG). We performed 16S rRNA gene sequencing on the gut microbiota samples. Taxonomic phylogeny at days 10 and 730 was significantly associated with childhood BMI, and the gut microbiota taxa at two years of age explained over 50% of the variation in childhood BMI in this cohort. The subset of the early-life taxa within the gut microbiota that best predicted later childhood BMI showed substantial overlap with the maternal taxa most strongly associated with maternal Ow/Ob and excessive GWG. Our results show an association between the infant gut microbiota and later BMI, and they offer preliminary evidence that the infant gut microbiota, particularly at 2 years of age, may have potential to help identify children at risk for obesity. IMPORTANCE Understanding the role of the early-life gut microbiota in obesity is important because there may be opportunities for preventive strategies. We examined the relationships between infant gut microbiota at six times during the first two years of life and BMI at age 12 in a birth cohort of 165 children and their mothers. We found that the gut microbiota from early life to two years shows an increasingly strong association with childhood BMI. This study provides preliminary evidence that the gut microbiome at 2 years of age may offer useful information to help to identify youth who are at risk for obesity, which could facilitate more-targeted early prevention efforts.
format	article
author	Maggie A. Stanislawski Dana Dabelea Brandie D. Wagner Nina Iszatt Cecilie Dahl Marci K. Sontag Rob Knight Catherine A. Lozupone Merete Eggesbø
author_facet	Maggie A. Stanislawski Dana Dabelea Brandie D. Wagner Nina Iszatt Cecilie Dahl Marci K. Sontag Rob Knight Catherine A. Lozupone Merete Eggesbø
author_sort	Maggie A. Stanislawski
title	Gut Microbiota in the First 2 Years of Life and the Association with Body Mass Index at Age 12 in a Norwegian Birth Cohort
title_short	Gut Microbiota in the First 2 Years of Life and the Association with Body Mass Index at Age 12 in a Norwegian Birth Cohort
title_full	Gut Microbiota in the First 2 Years of Life and the Association with Body Mass Index at Age 12 in a Norwegian Birth Cohort
title_fullStr	Gut Microbiota in the First 2 Years of Life and the Association with Body Mass Index at Age 12 in a Norwegian Birth Cohort
title_full_unstemmed	Gut Microbiota in the First 2 Years of Life and the Association with Body Mass Index at Age 12 in a Norwegian Birth Cohort
title_sort	gut microbiota in the first 2 years of life and the association with body mass index at age 12 in a norwegian birth cohort
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/4413fc1cd7bb46d08c1f93301fb05a81
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Gut Microbiota in the First 2 Years of Life and the Association with Body Mass Index at Age 12 in a Norwegian Birth Cohort

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