Chemical Analysis and <i>In Vitro</i> Bioactivity of Essential Oil of <i>Laurelia sempervirens</i> and Safrole Derivatives against Oomycete Fish Pathogens
In this study, the essential oil (EO) from <i>Laurelia sempervirens</i> was analyzed by GC/MS and safrole (<b>1</b>) was identified as the major metabolite <b>1</b>, was subjected to direct reactions on the oxygenated groups in the aromatic ring and in the side ch...
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| Autores principales: | , , , , , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/4414208d24bb47429c68d2c9fac51ddd |
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| Sumario: | In this study, the essential oil (EO) from <i>Laurelia sempervirens</i> was analyzed by GC/MS and safrole (<b>1</b>) was identified as the major metabolite <b>1</b>, was subjected to direct reactions on the oxygenated groups in the aromatic ring and in the side chain, and eight compounds (<b>4</b> to <b>12</b>) were obtained by the process. EO and compounds <b>4</b>–<b>12</b> were subjected to biological assays on 24 strains of the genus <i>Saprolegnia</i>, specifically of the species 12 <i>S.</i> <i>parasitica</i> and 12 <i>S.</i> <i>australis</i>. EO showed a significant effect against <i>Saprolegnia</i> strains. Compound <b>6</b> presents the highest activity against two resistant strains, with minimum inhibitory concentration (MIC) and minimum oomyceticidal concentration (MOC) values of 25 to 100 and 75 to 125 µg/mL, respectively. The results show that compound <b>6</b> exhibited superior activities compared to the commercial controls bronopol and azoxystrobin used to combat these pathogens. |
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