Chemical Analysis and In Vitro Bioactivity of Essential Oil of Laurelia sempervirens and Safrole Derivatives against Oomycete Fish Pathogens

In this study, the essential oil (EO) from Laurelia sempervirens was analyzed by GC/MS and safrole (1) was identified as the major metabolite 1, was subjected to direct reactions on the oxygenated groups in the aromatic ring and in the side ch...

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Autores principales:	Alejandro Madrid, Ana Lizeth Morales, Valentina Saffirio, Mauricio A. Cuellar, Enrique Werner, Bastián Said, Patricio Godoy, Nelson Caro, Mirna Melo, Iván Montenegro
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Laurelia sempervirens</i> safrol saprolegniosis nitrocompounds Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/4414208d24bb47429c68d2c9fac51ddd
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spelling	oai:doaj.org-article:4414208d24bb47429c68d2c9fac51ddd2021-11-11T18:32:06ZChemical Analysis and <i>In Vitro</i> Bioactivity of Essential Oil of <i>Laurelia sempervirens</i> and Safrole Derivatives against Oomycete Fish Pathogens10.3390/molecules262165511420-3049https://doaj.org/article/4414208d24bb47429c68d2c9fac51ddd2021-10-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6551https://doaj.org/toc/1420-3049In this study, the essential oil (EO) from <i>Laurelia sempervirens</i> was analyzed by GC/MS and safrole (<b>1</b>) was identified as the major metabolite <b>1</b>, was subjected to direct reactions on the oxygenated groups in the aromatic ring and in the side chain, and eight compounds (<b>4</b> to <b>12</b>) were obtained by the process. EO and compounds <b>4</b>–<b>12</b> were subjected to biological assays on 24 strains of the genus <i>Saprolegnia</i>, specifically of the species 12 <i>S.</i> <i>parasitica</i> and 12 <i>S.</i> <i>australis</i>. EO showed a significant effect against <i>Saprolegnia</i> strains. Compound <b>6</b> presents the highest activity against two resistant strains, with minimum inhibitory concentration (MIC) and minimum oomyceticidal concentration (MOC) values of 25 to 100 and 75 to 125 µg/mL, respectively. The results show that compound <b>6</b> exhibited superior activities compared to the commercial controls bronopol and azoxystrobin used to combat these pathogens.Alejandro MadridAna Lizeth MoralesValentina SaffirioMauricio A. CuellarEnrique WernerBastián SaidPatricio GodoyNelson CaroMirna MeloIván MontenegroMDPI AGarticle<i>Laurelia sempervirens</i>safrolsaprolegniosisnitrocompoundsOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6551, p 6551 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Laurelia sempervirens</i> safrol saprolegniosis nitrocompounds Organic chemistry QD241-441
spellingShingle	<i>Laurelia sempervirens</i> safrol saprolegniosis nitrocompounds Organic chemistry QD241-441 Alejandro Madrid Ana Lizeth Morales Valentina Saffirio Mauricio A. Cuellar Enrique Werner Bastián Said Patricio Godoy Nelson Caro Mirna Melo Iván Montenegro Chemical Analysis and <i>In Vitro</i> Bioactivity of Essential Oil of <i>Laurelia sempervirens</i> and Safrole Derivatives against Oomycete Fish Pathogens
description	In this study, the essential oil (EO) from <i>Laurelia sempervirens</i> was analyzed by GC/MS and safrole (<b>1</b>) was identified as the major metabolite <b>1</b>, was subjected to direct reactions on the oxygenated groups in the aromatic ring and in the side chain, and eight compounds (<b>4</b> to <b>12</b>) were obtained by the process. EO and compounds <b>4</b>–<b>12</b> were subjected to biological assays on 24 strains of the genus <i>Saprolegnia</i>, specifically of the species 12 <i>S.</i> <i>parasitica</i> and 12 <i>S.</i> <i>australis</i>. EO showed a significant effect against <i>Saprolegnia</i> strains. Compound <b>6</b> presents the highest activity against two resistant strains, with minimum inhibitory concentration (MIC) and minimum oomyceticidal concentration (MOC) values of 25 to 100 and 75 to 125 µg/mL, respectively. The results show that compound <b>6</b> exhibited superior activities compared to the commercial controls bronopol and azoxystrobin used to combat these pathogens.
format	article
author	Alejandro Madrid Ana Lizeth Morales Valentina Saffirio Mauricio A. Cuellar Enrique Werner Bastián Said Patricio Godoy Nelson Caro Mirna Melo Iván Montenegro
author_facet	Alejandro Madrid Ana Lizeth Morales Valentina Saffirio Mauricio A. Cuellar Enrique Werner Bastián Said Patricio Godoy Nelson Caro Mirna Melo Iván Montenegro
author_sort	Alejandro Madrid
title	Chemical Analysis and <i>In Vitro</i> Bioactivity of Essential Oil of <i>Laurelia sempervirens</i> and Safrole Derivatives against Oomycete Fish Pathogens
title_short	Chemical Analysis and <i>In Vitro</i> Bioactivity of Essential Oil of <i>Laurelia sempervirens</i> and Safrole Derivatives against Oomycete Fish Pathogens
title_full	Chemical Analysis and <i>In Vitro</i> Bioactivity of Essential Oil of <i>Laurelia sempervirens</i> and Safrole Derivatives against Oomycete Fish Pathogens
title_fullStr	Chemical Analysis and <i>In Vitro</i> Bioactivity of Essential Oil of <i>Laurelia sempervirens</i> and Safrole Derivatives against Oomycete Fish Pathogens
title_full_unstemmed	Chemical Analysis and <i>In Vitro</i> Bioactivity of Essential Oil of <i>Laurelia sempervirens</i> and Safrole Derivatives against Oomycete Fish Pathogens
title_sort	chemical analysis and <i>in vitro</i> bioactivity of essential oil of <i>laurelia sempervirens</i> and safrole derivatives against oomycete fish pathogens
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4414208d24bb47429c68d2c9fac51ddd
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Chemical Analysis and <i>In Vitro</i> Bioactivity of Essential Oil of <i>Laurelia sempervirens</i> and Safrole Derivatives against Oomycete Fish Pathogens

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