Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm
It is believed that mutations in desmosomal adhesion complex protein plakophilin 2 (PKP2) cause arrhythmia due to loss of cell-cell communication. Here the authors show that PKP2 controls the expression of proteins involved in calcium cycling in adult mouse hearts, and that lack of PKP2 can cause ar...
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Nature Portfolio
2017
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oai:doaj.org-article:4417834a57fb40c18499881ece963bc62021-12-02T10:48:18ZPlakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm10.1038/s41467-017-00127-02041-1723https://doaj.org/article/4417834a57fb40c18499881ece963bc62017-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00127-0https://doaj.org/toc/2041-1723It is believed that mutations in desmosomal adhesion complex protein plakophilin 2 (PKP2) cause arrhythmia due to loss of cell-cell communication. Here the authors show that PKP2 controls the expression of proteins involved in calcium cycling in adult mouse hearts, and that lack of PKP2 can cause arrhythmia in a structurally normal heart.Marina CerroneJerome MontnachXianming LinYan-Ting ZhaoMingliang ZhangEsperanza Agullo-PascualAlejandra Leo-MaciasFrancisco J. AlvaradoIgor DolgalevThomas V. KarathanosKabir MalkaniChantal J.M. Van OpbergenJoanne J.A. van BavelHua-Qian YangCarolina VasquezDavid TesterSteven FowlerFengxia LiangEli RothenbergAdriana HeguyGregory E. MorleyWilliam A. CoetzeeNatalia A. TrayanovaMichael J. AckermanToon A.B. van VeenHector H. ValdiviaMario DelmarNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017) |
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DOAJ |
| language |
EN |
| topic |
Science Q |
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Science Q Marina Cerrone Jerome Montnach Xianming Lin Yan-Ting Zhao Mingliang Zhang Esperanza Agullo-Pascual Alejandra Leo-Macias Francisco J. Alvarado Igor Dolgalev Thomas V. Karathanos Kabir Malkani Chantal J.M. Van Opbergen Joanne J.A. van Bavel Hua-Qian Yang Carolina Vasquez David Tester Steven Fowler Fengxia Liang Eli Rothenberg Adriana Heguy Gregory E. Morley William A. Coetzee Natalia A. Trayanova Michael J. Ackerman Toon A.B. van Veen Hector H. Valdivia Mario Delmar Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm |
| description |
It is believed that mutations in desmosomal adhesion complex protein plakophilin 2 (PKP2) cause arrhythmia due to loss of cell-cell communication. Here the authors show that PKP2 controls the expression of proteins involved in calcium cycling in adult mouse hearts, and that lack of PKP2 can cause arrhythmia in a structurally normal heart. |
| format |
article |
| author |
Marina Cerrone Jerome Montnach Xianming Lin Yan-Ting Zhao Mingliang Zhang Esperanza Agullo-Pascual Alejandra Leo-Macias Francisco J. Alvarado Igor Dolgalev Thomas V. Karathanos Kabir Malkani Chantal J.M. Van Opbergen Joanne J.A. van Bavel Hua-Qian Yang Carolina Vasquez David Tester Steven Fowler Fengxia Liang Eli Rothenberg Adriana Heguy Gregory E. Morley William A. Coetzee Natalia A. Trayanova Michael J. Ackerman Toon A.B. van Veen Hector H. Valdivia Mario Delmar |
| author_facet |
Marina Cerrone Jerome Montnach Xianming Lin Yan-Ting Zhao Mingliang Zhang Esperanza Agullo-Pascual Alejandra Leo-Macias Francisco J. Alvarado Igor Dolgalev Thomas V. Karathanos Kabir Malkani Chantal J.M. Van Opbergen Joanne J.A. van Bavel Hua-Qian Yang Carolina Vasquez David Tester Steven Fowler Fengxia Liang Eli Rothenberg Adriana Heguy Gregory E. Morley William A. Coetzee Natalia A. Trayanova Michael J. Ackerman Toon A.B. van Veen Hector H. Valdivia Mario Delmar |
| author_sort |
Marina Cerrone |
| title |
Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm |
| title_short |
Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm |
| title_full |
Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm |
| title_fullStr |
Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm |
| title_full_unstemmed |
Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm |
| title_sort |
plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/4417834a57fb40c18499881ece963bc6 |
| work_keys_str_mv |
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