Data-driven analysis of kappa opioid receptor binding in major depressive disorder measured by positron emission tomography

Abstract Preclinical studies have implicated kappa opioid receptors (KORs) in stress responses and depression-related behaviors, but evidence from human studies is limited. Here we present results of a secondary analysis of data acquired using positron emission tomography (PET) with the KOR radiotra...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kelly Smart, Ashley Yttredahl, Maria A. Oquendo, J. John Mann, Ansel T. Hillmer, Richard E. Carson, Jeffrey M. Miller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/441a7b9029424e3c8bf9ec359a4e5342
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:441a7b9029424e3c8bf9ec359a4e5342
record_format	dspace
spelling	oai:doaj.org-article:441a7b9029424e3c8bf9ec359a4e53422021-11-28T12:09:30ZData-driven analysis of kappa opioid receptor binding in major depressive disorder measured by positron emission tomography10.1038/s41398-021-01729-52158-3188https://doaj.org/article/441a7b9029424e3c8bf9ec359a4e53422021-11-01T00:00:00Zhttps://doi.org/10.1038/s41398-021-01729-5https://doaj.org/toc/2158-3188Abstract Preclinical studies have implicated kappa opioid receptors (KORs) in stress responses and depression-related behaviors, but evidence from human studies is limited. Here we present results of a secondary analysis of data acquired using positron emission tomography (PET) with the KOR radiotracer [11C]GR103545 in 10 unmedicated, currently depressed individuals with major depressive disorder (MDD; 32.6 ± 6.5 years, 5 women) and 13 healthy volunteers (34.8 ± 10 years, 6 women). Independent component analysis was performed to identify spatial patterns of coherent variance in KOR binding (tracer volume of distribution, V T) across all subjects. Expression of each component was compared between groups and relationships to symptoms were explored using the 17-item Hamilton Depression Rating Scale (HDRS). Three components of variation in KOR availability across ROIs were identified, spatially characterized by [11C]GR103545 V T in (1) bilateral frontal lobe; (2) occipital and parietal cortices, right hippocampus, and putamen; and (3) right anterior cingulate, right superior frontal gyrus and insula, coupled to negative loading in left middle cingulate. In MDD patients, component 3 was negatively associated with symptom severity on the HDRS (r = −0.85, p = 0.0021). There were no group-wise differences in expression of any component between patients and controls. These preliminary findings suggest that KOR signaling in cortical regions relevant to depression, particularly right anterior cingulate, could reflect MDD pathophysiology.Kelly SmartAshley YttredahlMaria A. OquendoJ. John MannAnsel T. HillmerRichard E. CarsonJeffrey M. MillerNature Publishing GrouparticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENTranslational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Kelly Smart Ashley Yttredahl Maria A. Oquendo J. John Mann Ansel T. Hillmer Richard E. Carson Jeffrey M. Miller Data-driven analysis of kappa opioid receptor binding in major depressive disorder measured by positron emission tomography
description	Abstract Preclinical studies have implicated kappa opioid receptors (KORs) in stress responses and depression-related behaviors, but evidence from human studies is limited. Here we present results of a secondary analysis of data acquired using positron emission tomography (PET) with the KOR radiotracer [11C]GR103545 in 10 unmedicated, currently depressed individuals with major depressive disorder (MDD; 32.6 ± 6.5 years, 5 women) and 13 healthy volunteers (34.8 ± 10 years, 6 women). Independent component analysis was performed to identify spatial patterns of coherent variance in KOR binding (tracer volume of distribution, V T) across all subjects. Expression of each component was compared between groups and relationships to symptoms were explored using the 17-item Hamilton Depression Rating Scale (HDRS). Three components of variation in KOR availability across ROIs were identified, spatially characterized by [11C]GR103545 V T in (1) bilateral frontal lobe; (2) occipital and parietal cortices, right hippocampus, and putamen; and (3) right anterior cingulate, right superior frontal gyrus and insula, coupled to negative loading in left middle cingulate. In MDD patients, component 3 was negatively associated with symptom severity on the HDRS (r = −0.85, p = 0.0021). There were no group-wise differences in expression of any component between patients and controls. These preliminary findings suggest that KOR signaling in cortical regions relevant to depression, particularly right anterior cingulate, could reflect MDD pathophysiology.
format	article
author	Kelly Smart Ashley Yttredahl Maria A. Oquendo J. John Mann Ansel T. Hillmer Richard E. Carson Jeffrey M. Miller
author_facet	Kelly Smart Ashley Yttredahl Maria A. Oquendo J. John Mann Ansel T. Hillmer Richard E. Carson Jeffrey M. Miller
author_sort	Kelly Smart
title	Data-driven analysis of kappa opioid receptor binding in major depressive disorder measured by positron emission tomography
title_short	Data-driven analysis of kappa opioid receptor binding in major depressive disorder measured by positron emission tomography
title_full	Data-driven analysis of kappa opioid receptor binding in major depressive disorder measured by positron emission tomography
title_fullStr	Data-driven analysis of kappa opioid receptor binding in major depressive disorder measured by positron emission tomography
title_full_unstemmed	Data-driven analysis of kappa opioid receptor binding in major depressive disorder measured by positron emission tomography
title_sort	data-driven analysis of kappa opioid receptor binding in major depressive disorder measured by positron emission tomography
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/441a7b9029424e3c8bf9ec359a4e5342
work_keys_str_mv	AT kellysmart datadrivenanalysisofkappaopioidreceptorbindinginmajordepressivedisordermeasuredbypositronemissiontomography AT ashleyyttredahl datadrivenanalysisofkappaopioidreceptorbindinginmajordepressivedisordermeasuredbypositronemissiontomography AT mariaaoquendo datadrivenanalysisofkappaopioidreceptorbindinginmajordepressivedisordermeasuredbypositronemissiontomography AT jjohnmann datadrivenanalysisofkappaopioidreceptorbindinginmajordepressivedisordermeasuredbypositronemissiontomography AT anselthillmer datadrivenanalysisofkappaopioidreceptorbindinginmajordepressivedisordermeasuredbypositronemissiontomography AT richardecarson datadrivenanalysisofkappaopioidreceptorbindinginmajordepressivedisordermeasuredbypositronemissiontomography AT jeffreymmiller datadrivenanalysisofkappaopioidreceptorbindinginmajordepressivedisordermeasuredbypositronemissiontomography
_version_	1718408134960087040

Data-driven analysis of kappa opioid receptor binding in major depressive disorder measured by positron emission tomography

Ejemplares similares