Examining the Relationship Between Hair Cortisol With Stress-Related and Transdiagnostic Subclinical Measures

Background: Hair cortisol concentrations (HCC) provide a retrospective examination of long-term cortisol production as a measure of the hypothalamic-pituitary-adrenal (HPA) axis functioning, one of the major neural systems implicated in mediating the effects of stress on mental illness. However, evi...

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Autores principales:	Pilar Torrecilla, Neus Barrantes-Vidal
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	hair cortisol stress hypothalamic-pituitary-adrenal axis transdiagnostic subclinical symptoms schizotypy Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/441d377ffea64241b4a3c7e38c1f9ea5
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spelling	oai:doaj.org-article:441d377ffea64241b4a3c7e38c1f9ea52021-11-11T06:06:20ZExamining the Relationship Between Hair Cortisol With Stress-Related and Transdiagnostic Subclinical Measures1664-064010.3389/fpsyt.2021.746155https://doaj.org/article/441d377ffea64241b4a3c7e38c1f9ea52021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpsyt.2021.746155/fullhttps://doaj.org/toc/1664-0640Background: Hair cortisol concentrations (HCC) provide a retrospective examination of long-term cortisol production as a measure of the hypothalamic-pituitary-adrenal (HPA) axis functioning, one of the major neural systems implicated in mediating the effects of stress on mental illness. However, evidence about the relationship between HCC with stressors and symptoms is scattered. In the present study, we aimed to examine the association between HCC and a wide range of stress-related and transdiagnostic subclinical measures in a sample of non-clinical young adults with a wide distribution of schizotypy.Methods: A total sample of 132 non-clinical young adults recruited at college and technical schools oversampled for schizotypy scores were assessed on distal and proximal stressful experiences, appraisals of stress, traits and symptoms of the affective, psychosis and dissociation spectrums, as well as stress-buffering measures, and provided 3 cm-hair samples.Results: No significant associations were found between HCC and any of the stress-related and subclinical measures. Only suspiciousness and disorganization showed a trend for a positive association with HCC but the magnitude was small.Conclusions: The present findings support previous studies indicating an overall lack of concordance between a broad range of stress-related and (sub)clinical phenotypic measures with hair cortisol. This study examined for the first time the relationship of HCC with the non-clinical expression of the psychosis spectrum, that is, schizotypy, which complements previous studies on clinical high risk and established psychosis and offers a promising strategy for studying possible HPA dysfunctions characterizing the subclinical psychosis continuum without the confounds associated to clinical psychosis.Pilar TorrecillaNeus Barrantes-VidalNeus Barrantes-VidalNeus Barrantes-VidalFrontiers Media S.A.articlehair cortisolstresshypothalamic-pituitary-adrenal axistransdiagnosticsubclinical symptomsschizotypyPsychiatryRC435-571ENFrontiers in Psychiatry, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hair cortisol stress hypothalamic-pituitary-adrenal axis transdiagnostic subclinical symptoms schizotypy Psychiatry RC435-571
spellingShingle	hair cortisol stress hypothalamic-pituitary-adrenal axis transdiagnostic subclinical symptoms schizotypy Psychiatry RC435-571 Pilar Torrecilla Neus Barrantes-Vidal Neus Barrantes-Vidal Neus Barrantes-Vidal Examining the Relationship Between Hair Cortisol With Stress-Related and Transdiagnostic Subclinical Measures
description	Background: Hair cortisol concentrations (HCC) provide a retrospective examination of long-term cortisol production as a measure of the hypothalamic-pituitary-adrenal (HPA) axis functioning, one of the major neural systems implicated in mediating the effects of stress on mental illness. However, evidence about the relationship between HCC with stressors and symptoms is scattered. In the present study, we aimed to examine the association between HCC and a wide range of stress-related and transdiagnostic subclinical measures in a sample of non-clinical young adults with a wide distribution of schizotypy.Methods: A total sample of 132 non-clinical young adults recruited at college and technical schools oversampled for schizotypy scores were assessed on distal and proximal stressful experiences, appraisals of stress, traits and symptoms of the affective, psychosis and dissociation spectrums, as well as stress-buffering measures, and provided 3 cm-hair samples.Results: No significant associations were found between HCC and any of the stress-related and subclinical measures. Only suspiciousness and disorganization showed a trend for a positive association with HCC but the magnitude was small.Conclusions: The present findings support previous studies indicating an overall lack of concordance between a broad range of stress-related and (sub)clinical phenotypic measures with hair cortisol. This study examined for the first time the relationship of HCC with the non-clinical expression of the psychosis spectrum, that is, schizotypy, which complements previous studies on clinical high risk and established psychosis and offers a promising strategy for studying possible HPA dysfunctions characterizing the subclinical psychosis continuum without the confounds associated to clinical psychosis.
format	article
author	Pilar Torrecilla Neus Barrantes-Vidal Neus Barrantes-Vidal Neus Barrantes-Vidal
author_facet	Pilar Torrecilla Neus Barrantes-Vidal Neus Barrantes-Vidal Neus Barrantes-Vidal
author_sort	Pilar Torrecilla
title	Examining the Relationship Between Hair Cortisol With Stress-Related and Transdiagnostic Subclinical Measures
title_short	Examining the Relationship Between Hair Cortisol With Stress-Related and Transdiagnostic Subclinical Measures
title_full	Examining the Relationship Between Hair Cortisol With Stress-Related and Transdiagnostic Subclinical Measures
title_fullStr	Examining the Relationship Between Hair Cortisol With Stress-Related and Transdiagnostic Subclinical Measures
title_full_unstemmed	Examining the Relationship Between Hair Cortisol With Stress-Related and Transdiagnostic Subclinical Measures
title_sort	examining the relationship between hair cortisol with stress-related and transdiagnostic subclinical measures
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/441d377ffea64241b4a3c7e38c1f9ea5
work_keys_str_mv	AT pilartorrecilla examiningtherelationshipbetweenhaircortisolwithstressrelatedandtransdiagnosticsubclinicalmeasures AT neusbarrantesvidal examiningtherelationshipbetweenhaircortisolwithstressrelatedandtransdiagnosticsubclinicalmeasures AT neusbarrantesvidal examiningtherelationshipbetweenhaircortisolwithstressrelatedandtransdiagnosticsubclinicalmeasures AT neusbarrantesvidal examiningtherelationshipbetweenhaircortisolwithstressrelatedandtransdiagnosticsubclinicalmeasures
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Examining the Relationship Between Hair Cortisol With Stress-Related and Transdiagnostic Subclinical Measures

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