Frailty is associated with susceptibility and severity of pneumonia in older adults (A JAGES multilevel cross-sectional study)

Abstract Pneumonia is a leading cause of mortality among older adults worldwide. Recently, several studies reported that frailty was associated with mortality among older adults hospitalized due to respiratory infectious diseases, including pneumonia. However, it is unknown whether frailty is associ...

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Autores principales:	Kousuke Iwai-Saito, Yugo Shobugawa, Jun Aida, Katsunori Kondo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/441f10169f48458faf94f69286eccaf4
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spelling	oai:doaj.org-article:441f10169f48458faf94f69286eccaf42021-12-02T14:26:16ZFrailty is associated with susceptibility and severity of pneumonia in older adults (A JAGES multilevel cross-sectional study)10.1038/s41598-021-86854-32045-2322https://doaj.org/article/441f10169f48458faf94f69286eccaf42021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86854-3https://doaj.org/toc/2045-2322Abstract Pneumonia is a leading cause of mortality among older adults worldwide. Recently, several studies reported that frailty was associated with mortality among older adults hospitalized due to respiratory infectious diseases, including pneumonia. However, it is unknown whether frailty is associated with susceptibility to and severity of pneumonia in functionally-independent community-dwelling older adults. In this study, we examined whether frailty increased the susceptibility to pneumonia and hospitalization in older adults. We used cross-sectional data from the Japan Gerontological Evaluation Study; the data was collected by using mail-based, self-reported questionnaires from 177,991 functionally-independent community-dwelling older adults aged ≥ 65 years. Our results showed that frailty was significantly associated with both occurrence of and hospitalization due to pneumonia after adjustments with covariates; (Preference ratio {PR} 1.92, 95% confidence interval {95% CI} [1.66–2.22] and PR 1.80, 95% CI [1.42–2.28], respectively, p < 0.001 for the both). Pre-frailty was associated only with the occurrence of pneumonia. Besides, the instrumental activity of daily living, physical strength, nutrition status, oral function, homeboundness, and depression status in frail older adults were associated with either or both occurrence of and hospitalization due to pneumonia. Our results suggest that frailty influenced the susceptibility to and severity of pneumonia in older adults.Kousuke Iwai-SaitoYugo ShobugawaJun AidaKatsunori KondoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kousuke Iwai-Saito Yugo Shobugawa Jun Aida Katsunori Kondo Frailty is associated with susceptibility and severity of pneumonia in older adults (A JAGES multilevel cross-sectional study)
description	Abstract Pneumonia is a leading cause of mortality among older adults worldwide. Recently, several studies reported that frailty was associated with mortality among older adults hospitalized due to respiratory infectious diseases, including pneumonia. However, it is unknown whether frailty is associated with susceptibility to and severity of pneumonia in functionally-independent community-dwelling older adults. In this study, we examined whether frailty increased the susceptibility to pneumonia and hospitalization in older adults. We used cross-sectional data from the Japan Gerontological Evaluation Study; the data was collected by using mail-based, self-reported questionnaires from 177,991 functionally-independent community-dwelling older adults aged ≥ 65 years. Our results showed that frailty was significantly associated with both occurrence of and hospitalization due to pneumonia after adjustments with covariates; (Preference ratio {PR} 1.92, 95% confidence interval {95% CI} [1.66–2.22] and PR 1.80, 95% CI [1.42–2.28], respectively, p < 0.001 for the both). Pre-frailty was associated only with the occurrence of pneumonia. Besides, the instrumental activity of daily living, physical strength, nutrition status, oral function, homeboundness, and depression status in frail older adults were associated with either or both occurrence of and hospitalization due to pneumonia. Our results suggest that frailty influenced the susceptibility to and severity of pneumonia in older adults.
format	article
author	Kousuke Iwai-Saito Yugo Shobugawa Jun Aida Katsunori Kondo
author_facet	Kousuke Iwai-Saito Yugo Shobugawa Jun Aida Katsunori Kondo
author_sort	Kousuke Iwai-Saito
title	Frailty is associated with susceptibility and severity of pneumonia in older adults (A JAGES multilevel cross-sectional study)
title_short	Frailty is associated with susceptibility and severity of pneumonia in older adults (A JAGES multilevel cross-sectional study)
title_full	Frailty is associated with susceptibility and severity of pneumonia in older adults (A JAGES multilevel cross-sectional study)
title_fullStr	Frailty is associated with susceptibility and severity of pneumonia in older adults (A JAGES multilevel cross-sectional study)
title_full_unstemmed	Frailty is associated with susceptibility and severity of pneumonia in older adults (A JAGES multilevel cross-sectional study)
title_sort	frailty is associated with susceptibility and severity of pneumonia in older adults (a jages multilevel cross-sectional study)
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/441f10169f48458faf94f69286eccaf4
work_keys_str_mv	AT kousukeiwaisaito frailtyisassociatedwithsusceptibilityandseverityofpneumoniainolderadultsajagesmultilevelcrosssectionalstudy AT yugoshobugawa frailtyisassociatedwithsusceptibilityandseverityofpneumoniainolderadultsajagesmultilevelcrosssectionalstudy AT junaida frailtyisassociatedwithsusceptibilityandseverityofpneumoniainolderadultsajagesmultilevelcrosssectionalstudy AT katsunorikondo frailtyisassociatedwithsusceptibilityandseverityofpneumoniainolderadultsajagesmultilevelcrosssectionalstudy
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Frailty is associated with susceptibility and severity of pneumonia in older adults (A JAGES multilevel cross-sectional study)

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