Advanced glycation end products and oxidative stress as a basis for metabolic abnormalities in patients with type 1 diabetes after successful simultaneous pancreas-kidney transplantation

Aim. To compare advanced glycation end-products (AGE, RAGE) and 3-nitrotyrosine (3-HT) in patients with DM 1 after successful simultaneous pancreas-kidney transplantation (SPK) and kidney transplantation alone (KTA). To assess relationship between levels of AGE, RAGE, 3-HT and renal transplant (RT)...

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Autores principales:	Irina I. Larina, Anastasia S. Severina, Irina S. Maganeva, Alina R. Ainetdinova, Anna K. Eremkina, Alina O. Gavrilova, Minara S. Shamhalova, Ilya V. Dmitriev, Aleksey V. Pinchuk, Marina V. Shestakova
Formato:	article
Lenguaje:	RU
Publicado:	"Consilium Medicum" Publishing house 2021
Materias:	diabetes mellitus transplantation advanced glycation end products oxidative stress Medicine R
Acceso en línea:	https://doaj.org/article/442220624e0b46fc819a1d6199e2fa7f
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spelling	oai:doaj.org-article:442220624e0b46fc819a1d6199e2fa7f2021-12-01T12:22:36ZAdvanced glycation end products and oxidative stress as a basis for metabolic abnormalities in patients with type 1 diabetes after successful simultaneous pancreas-kidney transplantation0040-36602309-534210.26442/00403660.2021.10.201100https://doaj.org/article/442220624e0b46fc819a1d6199e2fa7f2021-10-01T00:00:00Zhttps://ter-arkhiv.ru/0040-3660/article/viewFile/86666/65043https://doaj.org/toc/0040-3660https://doaj.org/toc/2309-5342Aim. To compare advanced glycation end-products (AGE, RAGE) and 3-nitrotyrosine (3-HT) in patients with DM 1 after successful simultaneous pancreas-kidney transplantation (SPK) and kidney transplantation alone (KTA). To assess relationship between levels of AGE, RAGE, 3-HT and renal transplant (RT) function, carbohydrate and mineral metabolism. Materials and methods. The study included 58 patients who received kidney transplantation in end-stage renal disease (ESRD). 36 patients received SPK. There were performed routine laboratory, examination of AGE, RAGE, 3-NT, parathyroid hormone (PTH), 25(OH)vitamin D, calcium, phosphorus, FGF23, osteoprotegerin (OPG), and fetuin-A levels. Results. All patients after SPK reached normoglycemia (HbA1c 5.7 [5.3; 6.1] %; C-peptide 3.24 [2.29; 4.40] ng/ml) with the achievement of significant difference vs patients after KTA. Arterial hypertension (AH) was more frequent in recipients of SPK before transplantation than after (p=0.008). AH also persisted in greater number of cases in patients after KTA than after SPK. Patients after SPK had higher AGE (р=0.0003) and lower RAGE (р=0.000003) levels. OPG in patients after SPK was significantly higher (р=0.04). The correlation analysis revealed significant positive correlation between 3-HT and OPG (p0.05; r=0.30), RAGE and eGFR (r=-0.52), HbA1c (r=0.48), duration of AH (r=0.34), AGE with HbA1c (r=0.51). Conclusion. The results of the "metabolic memory" markers analysis may indicate their contribution to the persistence of the metabolic consequences of CKD and DM 1 after achievement of normoglycemia and renal function restoration and their possible participation in development of recurrent nephropathy, vascular calcification, and bone disorders.Irina I. LarinaAnastasia S. SeverinaIrina S. MaganevaAlina R. AinetdinovaAnna K. EremkinaAlina O. GavrilovaMinara S. ShamhalovaIlya V. DmitrievAleksey V. PinchukMarina V. Shestakova"Consilium Medicum" Publishing housearticlediabetes mellitustransplantationadvanced glycation end productsoxidative stressMedicineRRUТерапевтический архив, Vol 93, Iss 10, Pp 1155-1163 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	diabetes mellitus transplantation advanced glycation end products oxidative stress Medicine R
spellingShingle	diabetes mellitus transplantation advanced glycation end products oxidative stress Medicine R Irina I. Larina Anastasia S. Severina Irina S. Maganeva Alina R. Ainetdinova Anna K. Eremkina Alina O. Gavrilova Minara S. Shamhalova Ilya V. Dmitriev Aleksey V. Pinchuk Marina V. Shestakova Advanced glycation end products and oxidative stress as a basis for metabolic abnormalities in patients with type 1 diabetes after successful simultaneous pancreas-kidney transplantation
description	Aim. To compare advanced glycation end-products (AGE, RAGE) and 3-nitrotyrosine (3-HT) in patients with DM 1 after successful simultaneous pancreas-kidney transplantation (SPK) and kidney transplantation alone (KTA). To assess relationship between levels of AGE, RAGE, 3-HT and renal transplant (RT) function, carbohydrate and mineral metabolism. Materials and methods. The study included 58 patients who received kidney transplantation in end-stage renal disease (ESRD). 36 patients received SPK. There were performed routine laboratory, examination of AGE, RAGE, 3-NT, parathyroid hormone (PTH), 25(OH)vitamin D, calcium, phosphorus, FGF23, osteoprotegerin (OPG), and fetuin-A levels. Results. All patients after SPK reached normoglycemia (HbA1c 5.7 [5.3; 6.1] %; C-peptide 3.24 [2.29; 4.40] ng/ml) with the achievement of significant difference vs patients after KTA. Arterial hypertension (AH) was more frequent in recipients of SPK before transplantation than after (p=0.008). AH also persisted in greater number of cases in patients after KTA than after SPK. Patients after SPK had higher AGE (р=0.0003) and lower RAGE (р=0.000003) levels. OPG in patients after SPK was significantly higher (р=0.04). The correlation analysis revealed significant positive correlation between 3-HT and OPG (p0.05; r=0.30), RAGE and eGFR (r=-0.52), HbA1c (r=0.48), duration of AH (r=0.34), AGE with HbA1c (r=0.51). Conclusion. The results of the "metabolic memory" markers analysis may indicate their contribution to the persistence of the metabolic consequences of CKD and DM 1 after achievement of normoglycemia and renal function restoration and their possible participation in development of recurrent nephropathy, vascular calcification, and bone disorders.
format	article
author	Irina I. Larina Anastasia S. Severina Irina S. Maganeva Alina R. Ainetdinova Anna K. Eremkina Alina O. Gavrilova Minara S. Shamhalova Ilya V. Dmitriev Aleksey V. Pinchuk Marina V. Shestakova
author_facet	Irina I. Larina Anastasia S. Severina Irina S. Maganeva Alina R. Ainetdinova Anna K. Eremkina Alina O. Gavrilova Minara S. Shamhalova Ilya V. Dmitriev Aleksey V. Pinchuk Marina V. Shestakova
author_sort	Irina I. Larina
title	Advanced glycation end products and oxidative stress as a basis for metabolic abnormalities in patients with type 1 diabetes after successful simultaneous pancreas-kidney transplantation
title_short	Advanced glycation end products and oxidative stress as a basis for metabolic abnormalities in patients with type 1 diabetes after successful simultaneous pancreas-kidney transplantation
title_full	Advanced glycation end products and oxidative stress as a basis for metabolic abnormalities in patients with type 1 diabetes after successful simultaneous pancreas-kidney transplantation
title_fullStr	Advanced glycation end products and oxidative stress as a basis for metabolic abnormalities in patients with type 1 diabetes after successful simultaneous pancreas-kidney transplantation
title_full_unstemmed	Advanced glycation end products and oxidative stress as a basis for metabolic abnormalities in patients with type 1 diabetes after successful simultaneous pancreas-kidney transplantation
title_sort	advanced glycation end products and oxidative stress as a basis for metabolic abnormalities in patients with type 1 diabetes after successful simultaneous pancreas-kidney transplantation
publisher	"Consilium Medicum" Publishing house
publishDate	2021
url	https://doaj.org/article/442220624e0b46fc819a1d6199e2fa7f
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Advanced glycation end products and oxidative stress as a basis for metabolic abnormalities in patients with type 1 diabetes after successful simultaneous pancreas-kidney transplantation

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