circPTEN suppresses colorectal cancer progression through regulating PTEN/AKT pathway

Recently, circular RNAs (circRNAs) have attracted growing attention due to their pivotal roles in the complicated cellular processes of diverse human malignancies, including colorectal cancer (CRC). Phosphatase and tensin homolog (PTEN) is known as a typical tumor-suppressing gene. Nevertheless, lim...

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Autores principales:	Chen Li, Xu Li
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	colorectal cancer circPTEN miR-4470 AKT TRAF6 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/44247a3da9064db4a8a342975c4095c3
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spelling	oai:doaj.org-article:44247a3da9064db4a8a342975c4095c32021-12-02T05:00:27ZcircPTEN suppresses colorectal cancer progression through regulating PTEN/AKT pathway2162-253110.1016/j.omtn.2021.05.018https://doaj.org/article/44247a3da9064db4a8a342975c4095c32021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2162253121001347https://doaj.org/toc/2162-2531Recently, circular RNAs (circRNAs) have attracted growing attention due to their pivotal roles in the complicated cellular processes of diverse human malignancies, including colorectal cancer (CRC). Phosphatase and tensin homolog (PTEN) is known as a typical tumor-suppressing gene. Nevertheless, limited investigation on the function of circRNAs generated from PTEN has been undertaken. In this research, hsa_circ_0094343 (circPTEN) was found to display low expression in CRC tissues and cells. CircPTEN is characterized with high stability due to its circular structure. Upregulation of circPTEN suppressed CRC cell proliferation, migration, and invasion but facilitated apoptosis. Data from mechanism assays revealed that circPTEN could elevate PTEN expression through sequestering microRNA-4470 (miR-4470) in CRC cells. Further, circPTEN was validated to inhibit K63-linked ubiquitination of protein kinase B (AKT) and AKT phosphorylation at Thr-308 and Ser-473 by competitively binding with tumor necrosis factor (TNF)-receptor-associated factor 6 (TRAF6). Moreover, the results of rescue assays indicated that the suppressive effect of circPTEN on CRC progression could be totally reversed by overexpression of insulin like growth factor 1 (IGF-1) or partially reversed by knockdown of PTEN. To conclude, circPTEN suppresses CRC progression via regulation of PTEN/AKT pathway.Chen LiXu LiElsevierarticlecolorectal cancercircPTENmiR-4470AKTTRAF6Therapeutics. PharmacologyRM1-950ENMolecular Therapy: Nucleic Acids, Vol 26, Iss , Pp 1418-1432 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	colorectal cancer circPTEN miR-4470 AKT TRAF6 Therapeutics. Pharmacology RM1-950
spellingShingle	colorectal cancer circPTEN miR-4470 AKT TRAF6 Therapeutics. Pharmacology RM1-950 Chen Li Xu Li circPTEN suppresses colorectal cancer progression through regulating PTEN/AKT pathway
description	Recently, circular RNAs (circRNAs) have attracted growing attention due to their pivotal roles in the complicated cellular processes of diverse human malignancies, including colorectal cancer (CRC). Phosphatase and tensin homolog (PTEN) is known as a typical tumor-suppressing gene. Nevertheless, limited investigation on the function of circRNAs generated from PTEN has been undertaken. In this research, hsa_circ_0094343 (circPTEN) was found to display low expression in CRC tissues and cells. CircPTEN is characterized with high stability due to its circular structure. Upregulation of circPTEN suppressed CRC cell proliferation, migration, and invasion but facilitated apoptosis. Data from mechanism assays revealed that circPTEN could elevate PTEN expression through sequestering microRNA-4470 (miR-4470) in CRC cells. Further, circPTEN was validated to inhibit K63-linked ubiquitination of protein kinase B (AKT) and AKT phosphorylation at Thr-308 and Ser-473 by competitively binding with tumor necrosis factor (TNF)-receptor-associated factor 6 (TRAF6). Moreover, the results of rescue assays indicated that the suppressive effect of circPTEN on CRC progression could be totally reversed by overexpression of insulin like growth factor 1 (IGF-1) or partially reversed by knockdown of PTEN. To conclude, circPTEN suppresses CRC progression via regulation of PTEN/AKT pathway.
format	article
author	Chen Li Xu Li
author_facet	Chen Li Xu Li
author_sort	Chen Li
title	circPTEN suppresses colorectal cancer progression through regulating PTEN/AKT pathway
title_short	circPTEN suppresses colorectal cancer progression through regulating PTEN/AKT pathway
title_full	circPTEN suppresses colorectal cancer progression through regulating PTEN/AKT pathway
title_fullStr	circPTEN suppresses colorectal cancer progression through regulating PTEN/AKT pathway
title_full_unstemmed	circPTEN suppresses colorectal cancer progression through regulating PTEN/AKT pathway
title_sort	circpten suppresses colorectal cancer progression through regulating pten/akt pathway
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/44247a3da9064db4a8a342975c4095c3
work_keys_str_mv	AT chenli circptensuppressescolorectalcancerprogressionthroughregulatingptenaktpathway AT xuli circptensuppressescolorectalcancerprogressionthroughregulatingptenaktpathway
_version_	1718400824574476288

circPTEN suppresses colorectal cancer progression through regulating PTEN/AKT pathway

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