Water-soluble l-cysteine-coated FePt nanoparticles as dual MRI/CT imaging contrast agent for glioma

Shuyan Liang,1 Qing Zhou,1 Min Wang,2,3 Yanhong Zhu,1 Qingzhi Wu,2,3 Xiangliang Yang1 1College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 2State Key Laboratory of Advanced Technology for Materials Synthesis and Proces...

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Autores principales:	Liang SY, Zhou Q, Wang M, Zhu YH, Wu QZ, Yang XL
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/44268c90815c44908348a882536e7c98
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spelling	oai:doaj.org-article:44268c90815c44908348a882536e7c982021-12-02T00:40:51ZWater-soluble l-cysteine-coated FePt nanoparticles as dual MRI/CT imaging contrast agent for glioma1178-2013https://doaj.org/article/44268c90815c44908348a882536e7c982015-03-01T00:00:00Zhttp://www.dovepress.com/water-soluble-l-cysteine-coated-fept-nanoparticles-as-dual-mrict-imagi-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013 Shuyan Liang,1 Qing Zhou,1 Min Wang,2,3 Yanhong Zhu,1 Qingzhi Wu,2,3 Xiangliang Yang1 1College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 2State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan, People’s Republic of China; 3Biomedical Material and Engineering Center of Hubei Province, Wuhan University of Technology, Wuhan, People’s Republic of China Abstract: Nanoparticles (NPs) are advantageous for the delivery of diagnosis agents to brain tumors. In this study, we attempted to develop an l-cysteine coated FePt (FePt-Cys) NP as MRI/CT imaging contrast agent for the diagnosis of malignant gliomas. FePt-Cys NPs were synthesized through a co-reduction route, which was characterized by transmission electron microscopy, high-resolution transmission electron microscopy, powder X-ray diffraction, Fourier transform infrared spectroscopy, and dynamic light scattering. The MRI and CT imaging ability of FePt-Cys NPs was evaluated using different gliomas cells (C6, SGH44, U251) as the model. Furthermore, the biocompatibility of the as-synthesized FePt-Cys NPs was evaluated using three different cell lines (ECV304, L929, and HEK293) as the model. The results showed that FePt-Cys NPs displayed excellent biocompatibility and good MRI/CT imaging ability, thereby indicating promising potential as a dual MRI/CT contrast agent for the diagnosis of brain malignant gliomas. Keywords: CT, glioma, MRILiang SYZhou QWang MZhu YHWu QZYang XLDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 2325-2333 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Liang SY Zhou Q Wang M Zhu YH Wu QZ Yang XL Water-soluble l-cysteine-coated FePt nanoparticles as dual MRI/CT imaging contrast agent for glioma
description	Shuyan Liang,1 Qing Zhou,1 Min Wang,2,3 Yanhong Zhu,1 Qingzhi Wu,2,3 Xiangliang Yang1 1College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 2State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan, People’s Republic of China; 3Biomedical Material and Engineering Center of Hubei Province, Wuhan University of Technology, Wuhan, People’s Republic of China Abstract: Nanoparticles (NPs) are advantageous for the delivery of diagnosis agents to brain tumors. In this study, we attempted to develop an l-cysteine coated FePt (FePt-Cys) NP as MRI/CT imaging contrast agent for the diagnosis of malignant gliomas. FePt-Cys NPs were synthesized through a co-reduction route, which was characterized by transmission electron microscopy, high-resolution transmission electron microscopy, powder X-ray diffraction, Fourier transform infrared spectroscopy, and dynamic light scattering. The MRI and CT imaging ability of FePt-Cys NPs was evaluated using different gliomas cells (C6, SGH44, U251) as the model. Furthermore, the biocompatibility of the as-synthesized FePt-Cys NPs was evaluated using three different cell lines (ECV304, L929, and HEK293) as the model. The results showed that FePt-Cys NPs displayed excellent biocompatibility and good MRI/CT imaging ability, thereby indicating promising potential as a dual MRI/CT contrast agent for the diagnosis of brain malignant gliomas. Keywords: CT, glioma, MRI
format	article
author	Liang SY Zhou Q Wang M Zhu YH Wu QZ Yang XL
author_facet	Liang SY Zhou Q Wang M Zhu YH Wu QZ Yang XL
author_sort	Liang SY
title	Water-soluble l-cysteine-coated FePt nanoparticles as dual MRI/CT imaging contrast agent for glioma
title_short	Water-soluble l-cysteine-coated FePt nanoparticles as dual MRI/CT imaging contrast agent for glioma
title_full	Water-soluble l-cysteine-coated FePt nanoparticles as dual MRI/CT imaging contrast agent for glioma
title_fullStr	Water-soluble l-cysteine-coated FePt nanoparticles as dual MRI/CT imaging contrast agent for glioma
title_full_unstemmed	Water-soluble l-cysteine-coated FePt nanoparticles as dual MRI/CT imaging contrast agent for glioma
title_sort	water-soluble l-cysteine-coated fept nanoparticles as dual mri/ct imaging contrast agent for glioma
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/44268c90815c44908348a882536e7c98
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_version_	1718403549719691264

Water-soluble l-cysteine-coated FePt nanoparticles as dual MRI/CT imaging contrast agent for glioma

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