Determining the Levels of Vitamin D and Parathyroid Hormone in Patients on Hemodialysis

Vitamin D deficiency is fequently observed in chronic kidney disease. We conducted this study to determine the concentration of the above-mentioned parameters and the correlation between them in order to optimize therapy with vitamin D in patients with end-stage renal disease (ESRD) on hemodialysis....

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Autores principales:	Mihaylov R., Pencheva B., Stoeva D., Marinova N., Krivoshiev S., Michailov G.
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2016
Materias:	vitamin d end-stage renal disease parathyroid hormone albuminuria albumin: creatinine ratio in the urine calcium phosphorus Medicine R
Acceso en línea:	https://doaj.org/article/442a55cfb2e140b8b91896f49d6e67aa
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spelling	oai:doaj.org-article:442a55cfb2e140b8b91896f49d6e67aa2021-12-02T19:11:12ZDetermining the Levels of Vitamin D and Parathyroid Hormone in Patients on Hemodialysis0324-175010.1515/amb-2016-0003https://doaj.org/article/442a55cfb2e140b8b91896f49d6e67aa2016-03-01T00:00:00Zhttps://doi.org/10.1515/amb-2016-0003https://doaj.org/toc/0324-1750Vitamin D deficiency is fequently observed in chronic kidney disease. We conducted this study to determine the concentration of the above-mentioned parameters and the correlation between them in order to optimize therapy with vitamin D in patients with end-stage renal disease (ESRD) on hemodialysis. In 53 patients on hemodialysis due to ESRD, vitamin D [Calcidiol (25(OH)D], parathyroid hormone (PTH), calcium, phosphorus, albuminuria, albumin:creatinine ratio (ACR) and other parameters have been followed up. Analysis of the levels of vitamin D has been carried out by High Performance Liquid Chromatography (HPLC), the PTH is determined by the system Centaur XP, Siemens Diagnostic, Electro-chemiluminescence immunoassay (ECLIA), and for albumin in urine we used immunological method [Miltigent microalbumin assay (Abbott Laboratories Diagnostics). We found out deficiency and insufficiency of vitamin D in 56.6% and 37.7%, as well as average 4.5 times increase in the PTH, hyperphosphatemia, hypocalcemia, albuminuria (A2 or A3), over 10 times increase in the ACR, secondary hyperparathyroidism. We registered a negative correlation between vitamin D and PTH. We confirmed the increase in creatinine and cystatin C in the patients on hemodialysis. There are few literature data for patients on hemodialysis, however, regarding the extent of the vitamin deficiency and its relationship with PTH, albuminuria, calcium, phosphorus, etc. Our data have indicated that patients on hemodialysis due to ESRD are associated with high incidence of vitamin D insufficiency or deficiency.Mihaylov R.Pencheva B.Stoeva D.Marinova N.Krivoshiev S.Michailov G.Sciendoarticlevitamin dend-stage renal diseaseparathyroid hormonealbuminuriaalbumin: creatinine ratio in the urinecalciumphosphorusMedicineRENActa Medica Bulgarica, Vol 43, Iss 1, Pp 23-29 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	vitamin d end-stage renal disease parathyroid hormone albuminuria albumin: creatinine ratio in the urine calcium phosphorus Medicine R
spellingShingle	vitamin d end-stage renal disease parathyroid hormone albuminuria albumin: creatinine ratio in the urine calcium phosphorus Medicine R Mihaylov R. Pencheva B. Stoeva D. Marinova N. Krivoshiev S. Michailov G. Determining the Levels of Vitamin D and Parathyroid Hormone in Patients on Hemodialysis
description	Vitamin D deficiency is fequently observed in chronic kidney disease. We conducted this study to determine the concentration of the above-mentioned parameters and the correlation between them in order to optimize therapy with vitamin D in patients with end-stage renal disease (ESRD) on hemodialysis. In 53 patients on hemodialysis due to ESRD, vitamin D [Calcidiol (25(OH)D], parathyroid hormone (PTH), calcium, phosphorus, albuminuria, albumin:creatinine ratio (ACR) and other parameters have been followed up. Analysis of the levels of vitamin D has been carried out by High Performance Liquid Chromatography (HPLC), the PTH is determined by the system Centaur XP, Siemens Diagnostic, Electro-chemiluminescence immunoassay (ECLIA), and for albumin in urine we used immunological method [Miltigent microalbumin assay (Abbott Laboratories Diagnostics). We found out deficiency and insufficiency of vitamin D in 56.6% and 37.7%, as well as average 4.5 times increase in the PTH, hyperphosphatemia, hypocalcemia, albuminuria (A2 or A3), over 10 times increase in the ACR, secondary hyperparathyroidism. We registered a negative correlation between vitamin D and PTH. We confirmed the increase in creatinine and cystatin C in the patients on hemodialysis. There are few literature data for patients on hemodialysis, however, regarding the extent of the vitamin deficiency and its relationship with PTH, albuminuria, calcium, phosphorus, etc. Our data have indicated that patients on hemodialysis due to ESRD are associated with high incidence of vitamin D insufficiency or deficiency.
format	article
author	Mihaylov R. Pencheva B. Stoeva D. Marinova N. Krivoshiev S. Michailov G.
author_facet	Mihaylov R. Pencheva B. Stoeva D. Marinova N. Krivoshiev S. Michailov G.
author_sort	Mihaylov R.
title	Determining the Levels of Vitamin D and Parathyroid Hormone in Patients on Hemodialysis
title_short	Determining the Levels of Vitamin D and Parathyroid Hormone in Patients on Hemodialysis
title_full	Determining the Levels of Vitamin D and Parathyroid Hormone in Patients on Hemodialysis
title_fullStr	Determining the Levels of Vitamin D and Parathyroid Hormone in Patients on Hemodialysis
title_full_unstemmed	Determining the Levels of Vitamin D and Parathyroid Hormone in Patients on Hemodialysis
title_sort	determining the levels of vitamin d and parathyroid hormone in patients on hemodialysis
publisher	Sciendo
publishDate	2016
url	https://doaj.org/article/442a55cfb2e140b8b91896f49d6e67aa
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Determining the Levels of Vitamin D and Parathyroid Hormone in Patients on Hemodialysis

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