Activation of Akt/mTOR pathway is associated with poor prognosis of nasopharyngeal carcinoma.

Nasopharyngeal carcinoma (NPC) is a malignant tumor of the head and neck region, which frequently occurs in Southeast Asia, especially in the south of China. It is known that the mammalian target of rapamycin (mTOR) pathway plays a central role in regulating cellular functions, including proliferati...

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Autores principales:	Weiyuan Wang, Qiuyuan Wen, Lina Xu, Guiyuan Xie, Jiao Li, Jiadi Luo, Shuzhou Chu, Lei Shi, Donghai Huang, Jinghe Li, Songqing Fan
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/442ba85392764e2c96a8ed60119f9ec3
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spelling	oai:doaj.org-article:442ba85392764e2c96a8ed60119f9ec32021-11-25T06:02:52ZActivation of Akt/mTOR pathway is associated with poor prognosis of nasopharyngeal carcinoma.1932-620310.1371/journal.pone.0106098https://doaj.org/article/442ba85392764e2c96a8ed60119f9ec32014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25165983/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Nasopharyngeal carcinoma (NPC) is a malignant tumor of the head and neck region, which frequently occurs in Southeast Asia, especially in the south of China. It is known that the mammalian target of rapamycin (mTOR) pathway plays a central role in regulating cellular functions, including proliferation, growth, survival, mobility, and angiogenesis. Aberrant expression of the mTOR signaling pathway molecules has been found in many types of cancer. However, whether the alterations of p-Akt, p-p70S6K and p-4EBP1 protein expression are associated with clinicopathological features and prognostic implications in NPC have not been reported. The purposes of the present study are to investigate the association between the expression of p-Akt, p-p70S6K and p-4EBP1 proteins and clinicopathological features in NPC by immunohistochemistry. The results showed that the positive percentage of p-Akt, p-p70S6K and p-4EBP1 proteins expression in NPC (47.2%, 73.0% and 61.7%, respectively) was significantly higher than that in the non-cancerous nasopharyngeal control tissue (33.3%, 59.1% and 47.0%, respectively). There was a significantly higher positive expression of p-Akt in undifferentiated non-keratinizing nasopharyngeal carcinoma than that in differentiated non-keratinizing nasopharyngeal carcinoma (P = 0.014). Additionally, positive expression of p-p70S6K and p-4EBP1 proteins, and positive expression of either of p-Akt, p-p70S6K and p-4EBP1 were significantly correlated inversely with overall survival rates of NPC patients (P = 0.023, P = 0.033, P = 0.008, respectively). Spearman's rank correlation test showed that expression of p-Akt in NPC was significantly associated with expression of p-p70S6K (r = 0.263, P<0.001) and p-4EBP1(r = 0.284, P<0.001). Also there was an obviously positive association between expression of p-p70S6K and p-4EBP1 proteins in NPC (r = 0.286, P<0.001). Multivariate Cox regression analysis further identified positive expression of p-4EBP1 and p-p70S6K proteins were the independent poor prognostic factors for NPC (P = 0.043, P = 0.027, respectively). Taken together, high expression of p-p70S6K and p-4EBP1 proteins may act as valuable independent biomarkers to predict a poor prognosis of NPC.Weiyuan WangQiuyuan WenLina XuGuiyuan XieJiao LiJiadi LuoShuzhou ChuLei ShiDonghai HuangJinghe LiSongqing FanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e106098 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Weiyuan Wang Qiuyuan Wen Lina Xu Guiyuan Xie Jiao Li Jiadi Luo Shuzhou Chu Lei Shi Donghai Huang Jinghe Li Songqing Fan Activation of Akt/mTOR pathway is associated with poor prognosis of nasopharyngeal carcinoma.
description	Nasopharyngeal carcinoma (NPC) is a malignant tumor of the head and neck region, which frequently occurs in Southeast Asia, especially in the south of China. It is known that the mammalian target of rapamycin (mTOR) pathway plays a central role in regulating cellular functions, including proliferation, growth, survival, mobility, and angiogenesis. Aberrant expression of the mTOR signaling pathway molecules has been found in many types of cancer. However, whether the alterations of p-Akt, p-p70S6K and p-4EBP1 protein expression are associated with clinicopathological features and prognostic implications in NPC have not been reported. The purposes of the present study are to investigate the association between the expression of p-Akt, p-p70S6K and p-4EBP1 proteins and clinicopathological features in NPC by immunohistochemistry. The results showed that the positive percentage of p-Akt, p-p70S6K and p-4EBP1 proteins expression in NPC (47.2%, 73.0% and 61.7%, respectively) was significantly higher than that in the non-cancerous nasopharyngeal control tissue (33.3%, 59.1% and 47.0%, respectively). There was a significantly higher positive expression of p-Akt in undifferentiated non-keratinizing nasopharyngeal carcinoma than that in differentiated non-keratinizing nasopharyngeal carcinoma (P = 0.014). Additionally, positive expression of p-p70S6K and p-4EBP1 proteins, and positive expression of either of p-Akt, p-p70S6K and p-4EBP1 were significantly correlated inversely with overall survival rates of NPC patients (P = 0.023, P = 0.033, P = 0.008, respectively). Spearman's rank correlation test showed that expression of p-Akt in NPC was significantly associated with expression of p-p70S6K (r = 0.263, P<0.001) and p-4EBP1(r = 0.284, P<0.001). Also there was an obviously positive association between expression of p-p70S6K and p-4EBP1 proteins in NPC (r = 0.286, P<0.001). Multivariate Cox regression analysis further identified positive expression of p-4EBP1 and p-p70S6K proteins were the independent poor prognostic factors for NPC (P = 0.043, P = 0.027, respectively). Taken together, high expression of p-p70S6K and p-4EBP1 proteins may act as valuable independent biomarkers to predict a poor prognosis of NPC.
format	article
author	Weiyuan Wang Qiuyuan Wen Lina Xu Guiyuan Xie Jiao Li Jiadi Luo Shuzhou Chu Lei Shi Donghai Huang Jinghe Li Songqing Fan
author_facet	Weiyuan Wang Qiuyuan Wen Lina Xu Guiyuan Xie Jiao Li Jiadi Luo Shuzhou Chu Lei Shi Donghai Huang Jinghe Li Songqing Fan
author_sort	Weiyuan Wang
title	Activation of Akt/mTOR pathway is associated with poor prognosis of nasopharyngeal carcinoma.
title_short	Activation of Akt/mTOR pathway is associated with poor prognosis of nasopharyngeal carcinoma.
title_full	Activation of Akt/mTOR pathway is associated with poor prognosis of nasopharyngeal carcinoma.
title_fullStr	Activation of Akt/mTOR pathway is associated with poor prognosis of nasopharyngeal carcinoma.
title_full_unstemmed	Activation of Akt/mTOR pathway is associated with poor prognosis of nasopharyngeal carcinoma.
title_sort	activation of akt/mtor pathway is associated with poor prognosis of nasopharyngeal carcinoma.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/442ba85392764e2c96a8ed60119f9ec3
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Activation of Akt/mTOR pathway is associated with poor prognosis of nasopharyngeal carcinoma.

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