Vascular Endothelial Growth Factor as a Putative Biomarker of Depression in Asthmatics with Reversible Airway Narrowing

The vascular endothelial growth factor (VEGF) plays a pivotal role in process of angiogenesis in adults. If angiogenesis is not properly controlled, its deregulation may implicate it in various psychosomatic diseases states. The aim of our study was to reveal possible correlation between severity of...

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Autores principales:	Krzysztof Gomułka, Jerzy Liebhart, Wojciech Mędrala
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	asthma biomarker depression ELISA-based detection vascular endothelial growth factor Medicine R
Acceso en línea:	https://doaj.org/article/442efae035204863a7fb8aa2652ba5da
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spelling	oai:doaj.org-article:442efae035204863a7fb8aa2652ba5da2021-11-25T18:01:37ZVascular Endothelial Growth Factor as a Putative Biomarker of Depression in Asthmatics with Reversible Airway Narrowing10.3390/jcm102253012077-0383https://doaj.org/article/442efae035204863a7fb8aa2652ba5da2021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5301https://doaj.org/toc/2077-0383The vascular endothelial growth factor (VEGF) plays a pivotal role in process of angiogenesis in adults. If angiogenesis is not properly controlled, its deregulation may implicate it in various psychosomatic diseases states. The aim of our study was to reveal possible correlation between severity of depression in asthmatics with different degrees of airway narrowing and serum vascular endothelial growth factor levels. The study population included a total of 122 adult subjects: 82 patients with asthma (among them 42 patients with irreversible bronchoconstriction and 40 patients with reversible bronchoconstriction) and 40 healthy participants as a control group. The standardized Beck Depression Inventory (BDI) was used to estimate the depression symptoms. Enzyme-linked immunosorbent assay (ELISA) was used to assess the VEGF serum concentration in all participants. There was a significant difference in depression symptoms in asthmatics with reversible (<i>p</i> = 0.0432) and irreversible airway obstruction (<i>p</i> = 0.00005) in comparison to control group and between these two subgroups of asthmatics (<i>p</i> = 0.0233). Obtained results revealed significant correlation between level of depression and mean VEGF serum concentration in asthmatics with reversible airway obstruction (<i>p</i> = 0.0202). There was no difference between enhanced depression symptoms and VEGF serum concentration in patients with irreversible airway obstruction nor in the total group of asthmatics (in both <i>p</i> > 0.05). The relationship between asthma severity and depression symptoms seems to be certain. VEGF might be considered as a putative biomarker of depression in asthmatics, mainly those with reversible airway narrowing.Krzysztof GomułkaJerzy LiebhartWojciech MędralaMDPI AGarticleasthmabiomarkerdepressionELISA-based detectionvascular endothelial growth factorMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5301, p 5301 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	asthma biomarker depression ELISA-based detection vascular endothelial growth factor Medicine R
spellingShingle	asthma biomarker depression ELISA-based detection vascular endothelial growth factor Medicine R Krzysztof Gomułka Jerzy Liebhart Wojciech Mędrala Vascular Endothelial Growth Factor as a Putative Biomarker of Depression in Asthmatics with Reversible Airway Narrowing
description	The vascular endothelial growth factor (VEGF) plays a pivotal role in process of angiogenesis in adults. If angiogenesis is not properly controlled, its deregulation may implicate it in various psychosomatic diseases states. The aim of our study was to reveal possible correlation between severity of depression in asthmatics with different degrees of airway narrowing and serum vascular endothelial growth factor levels. The study population included a total of 122 adult subjects: 82 patients with asthma (among them 42 patients with irreversible bronchoconstriction and 40 patients with reversible bronchoconstriction) and 40 healthy participants as a control group. The standardized Beck Depression Inventory (BDI) was used to estimate the depression symptoms. Enzyme-linked immunosorbent assay (ELISA) was used to assess the VEGF serum concentration in all participants. There was a significant difference in depression symptoms in asthmatics with reversible (<i>p</i> = 0.0432) and irreversible airway obstruction (<i>p</i> = 0.00005) in comparison to control group and between these two subgroups of asthmatics (<i>p</i> = 0.0233). Obtained results revealed significant correlation between level of depression and mean VEGF serum concentration in asthmatics with reversible airway obstruction (<i>p</i> = 0.0202). There was no difference between enhanced depression symptoms and VEGF serum concentration in patients with irreversible airway obstruction nor in the total group of asthmatics (in both <i>p</i> > 0.05). The relationship between asthma severity and depression symptoms seems to be certain. VEGF might be considered as a putative biomarker of depression in asthmatics, mainly those with reversible airway narrowing.
format	article
author	Krzysztof Gomułka Jerzy Liebhart Wojciech Mędrala
author_facet	Krzysztof Gomułka Jerzy Liebhart Wojciech Mędrala
author_sort	Krzysztof Gomułka
title	Vascular Endothelial Growth Factor as a Putative Biomarker of Depression in Asthmatics with Reversible Airway Narrowing
title_short	Vascular Endothelial Growth Factor as a Putative Biomarker of Depression in Asthmatics with Reversible Airway Narrowing
title_full	Vascular Endothelial Growth Factor as a Putative Biomarker of Depression in Asthmatics with Reversible Airway Narrowing
title_fullStr	Vascular Endothelial Growth Factor as a Putative Biomarker of Depression in Asthmatics with Reversible Airway Narrowing
title_full_unstemmed	Vascular Endothelial Growth Factor as a Putative Biomarker of Depression in Asthmatics with Reversible Airway Narrowing
title_sort	vascular endothelial growth factor as a putative biomarker of depression in asthmatics with reversible airway narrowing
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/442efae035204863a7fb8aa2652ba5da
work_keys_str_mv	AT krzysztofgomułka vascularendothelialgrowthfactorasaputativebiomarkerofdepressioninasthmaticswithreversibleairwaynarrowing AT jerzyliebhart vascularendothelialgrowthfactorasaputativebiomarkerofdepressioninasthmaticswithreversibleairwaynarrowing AT wojciechmedrala vascularendothelialgrowthfactorasaputativebiomarkerofdepressioninasthmaticswithreversibleairwaynarrowing
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Vascular Endothelial Growth Factor as a Putative Biomarker of Depression in Asthmatics with Reversible Airway Narrowing

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