Discovery of coding regions in the human genome by integrated proteogenomics analysis workflow

Proteogenomics enables the discovery of protein coding regions and disease-relevant mutations but their verification remains challenging. Here, the authors combine peptide discovery, curation and validation in an integrated proteogenomics workflow, robustly identifying unknown coding regions and mut...

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Autores principales:	Yafeng Zhu, Lukas M. Orre, Henrik J. Johansson, Mikael Huss, Jorrit Boekel, Mattias Vesterlund, Alejandro Fernandez-Woodbridge, Rui M. M. Branca, Janne Lehtiö
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/44312d94faad4197b162f991fca661ad
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spelling	oai:doaj.org-article:44312d94faad4197b162f991fca661ad2021-12-02T17:32:16ZDiscovery of coding regions in the human genome by integrated proteogenomics analysis workflow10.1038/s41467-018-03311-y2041-1723https://doaj.org/article/44312d94faad4197b162f991fca661ad2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03311-yhttps://doaj.org/toc/2041-1723Proteogenomics enables the discovery of protein coding regions and disease-relevant mutations but their verification remains challenging. Here, the authors combine peptide discovery, curation and validation in an integrated proteogenomics workflow, robustly identifying unknown coding regions and mutations.Yafeng ZhuLukas M. OrreHenrik J. JohanssonMikael HussJorrit BoekelMattias VesterlundAlejandro Fernandez-WoodbridgeRui M. M. BrancaJanne LehtiöNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yafeng Zhu Lukas M. Orre Henrik J. Johansson Mikael Huss Jorrit Boekel Mattias Vesterlund Alejandro Fernandez-Woodbridge Rui M. M. Branca Janne Lehtiö Discovery of coding regions in the human genome by integrated proteogenomics analysis workflow
description	Proteogenomics enables the discovery of protein coding regions and disease-relevant mutations but their verification remains challenging. Here, the authors combine peptide discovery, curation and validation in an integrated proteogenomics workflow, robustly identifying unknown coding regions and mutations.
format	article
author	Yafeng Zhu Lukas M. Orre Henrik J. Johansson Mikael Huss Jorrit Boekel Mattias Vesterlund Alejandro Fernandez-Woodbridge Rui M. M. Branca Janne Lehtiö
author_facet	Yafeng Zhu Lukas M. Orre Henrik J. Johansson Mikael Huss Jorrit Boekel Mattias Vesterlund Alejandro Fernandez-Woodbridge Rui M. M. Branca Janne Lehtiö
author_sort	Yafeng Zhu
title	Discovery of coding regions in the human genome by integrated proteogenomics analysis workflow
title_short	Discovery of coding regions in the human genome by integrated proteogenomics analysis workflow
title_full	Discovery of coding regions in the human genome by integrated proteogenomics analysis workflow
title_fullStr	Discovery of coding regions in the human genome by integrated proteogenomics analysis workflow
title_full_unstemmed	Discovery of coding regions in the human genome by integrated proteogenomics analysis workflow
title_sort	discovery of coding regions in the human genome by integrated proteogenomics analysis workflow
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/44312d94faad4197b162f991fca661ad
work_keys_str_mv	AT yafengzhu discoveryofcodingregionsinthehumangenomebyintegratedproteogenomicsanalysisworkflow AT lukasmorre discoveryofcodingregionsinthehumangenomebyintegratedproteogenomicsanalysisworkflow AT henrikjjohansson discoveryofcodingregionsinthehumangenomebyintegratedproteogenomicsanalysisworkflow AT mikaelhuss discoveryofcodingregionsinthehumangenomebyintegratedproteogenomicsanalysisworkflow AT jorritboekel discoveryofcodingregionsinthehumangenomebyintegratedproteogenomicsanalysisworkflow AT mattiasvesterlund discoveryofcodingregionsinthehumangenomebyintegratedproteogenomicsanalysisworkflow AT alejandrofernandezwoodbridge discoveryofcodingregionsinthehumangenomebyintegratedproteogenomicsanalysisworkflow AT ruimmbranca discoveryofcodingregionsinthehumangenomebyintegratedproteogenomicsanalysisworkflow AT jannelehtio discoveryofcodingregionsinthehumangenomebyintegratedproteogenomicsanalysisworkflow
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Discovery of coding regions in the human genome by integrated proteogenomics analysis workflow

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