Immune modulation underpins the anti‐cancer activity of HDAC inhibitors

Aberrant protein acetylation is strongly linked to tumorigenesis, and modulating acetylation through targeting histone deacetylase (HDAC) with small‐molecule inhibitors has been the focus of clinical trials. However, clinical success on solid tumours, such as colorectal cancer (CRC), has been limite...

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Autores principales: Wiktoria Blaszczak, Geng Liu, Hong Zhu, Wojciech Barczak, Amit Shrestha, Gulsah Albayrak, Shunsheng Zheng, David Kerr, Anastasia Samsonova, Nicholas B. La Thangue
Formato: article
Lenguaje:EN
Publicado: Wiley 2021
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Acceso en línea:https://doaj.org/article/44339e57e4864182884b12445438ede8
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