Dendrimer end-terminal motif-dependent evasion of human complement and complement activation through IgM hitchhiking

Understanding nanomaterials interactions with complement is important for a number of applications. Here, the authors study the interaction of sub 6 nm dendrimers with complement and show the small dendrimers escape complement activation but do interact with IgM to trigger lectin-pathway complement...

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Autores principales:	Lin-Ping Wu, Mario Ficker, Jørn B. Christensen, Dmitri Simberg, Panagiotis N. Trohopoulos, Seyed M. Moghimi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4434bb5d9dfb49f59c75cce00c6a6d84
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spelling	oai:doaj.org-article:4434bb5d9dfb49f59c75cce00c6a6d842021-12-02T16:27:56ZDendrimer end-terminal motif-dependent evasion of human complement and complement activation through IgM hitchhiking10.1038/s41467-021-24960-62041-1723https://doaj.org/article/4434bb5d9dfb49f59c75cce00c6a6d842021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24960-6https://doaj.org/toc/2041-1723Understanding nanomaterials interactions with complement is important for a number of applications. Here, the authors study the interaction of sub 6 nm dendrimers with complement and show the small dendrimers escape complement activation but do interact with IgM to trigger lectin-pathway complement activation.Lin-Ping WuMario FickerJørn B. ChristensenDmitri SimbergPanagiotis N. TrohopoulosSeyed M. MoghimiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lin-Ping Wu Mario Ficker Jørn B. Christensen Dmitri Simberg Panagiotis N. Trohopoulos Seyed M. Moghimi Dendrimer end-terminal motif-dependent evasion of human complement and complement activation through IgM hitchhiking
description	Understanding nanomaterials interactions with complement is important for a number of applications. Here, the authors study the interaction of sub 6 nm dendrimers with complement and show the small dendrimers escape complement activation but do interact with IgM to trigger lectin-pathway complement activation.
format	article
author	Lin-Ping Wu Mario Ficker Jørn B. Christensen Dmitri Simberg Panagiotis N. Trohopoulos Seyed M. Moghimi
author_facet	Lin-Ping Wu Mario Ficker Jørn B. Christensen Dmitri Simberg Panagiotis N. Trohopoulos Seyed M. Moghimi
author_sort	Lin-Ping Wu
title	Dendrimer end-terminal motif-dependent evasion of human complement and complement activation through IgM hitchhiking
title_short	Dendrimer end-terminal motif-dependent evasion of human complement and complement activation through IgM hitchhiking
title_full	Dendrimer end-terminal motif-dependent evasion of human complement and complement activation through IgM hitchhiking
title_fullStr	Dendrimer end-terminal motif-dependent evasion of human complement and complement activation through IgM hitchhiking
title_full_unstemmed	Dendrimer end-terminal motif-dependent evasion of human complement and complement activation through IgM hitchhiking
title_sort	dendrimer end-terminal motif-dependent evasion of human complement and complement activation through igm hitchhiking
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4434bb5d9dfb49f59c75cce00c6a6d84
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Dendrimer end-terminal motif-dependent evasion of human complement and complement activation through IgM hitchhiking

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