Seven Billion Microcosms: Evolution within Human Microbiomes

ABSTRACT Rational microbiome-based therapies may one day treat a wide range of diseases and promote wellness. Yet, we are still limited in our abilities to employ such therapies and to predict which bacterial strains have the potential to stably colonize a person. The Lieberman laboratory is working...

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Autor principal:	Tami D. Lieberman
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	evolution human microbiome microbial ecology within-person evolution evolutionary biology genomics Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/4435100d30b6480484c06c0e855c705d
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spelling	oai:doaj.org-article:4435100d30b6480484c06c0e855c705d2021-12-02T19:47:34ZSeven Billion Microcosms: Evolution within Human Microbiomes10.1128/mSystems.00171-172379-5077https://doaj.org/article/4435100d30b6480484c06c0e855c705d2018-04-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00171-17https://doaj.org/toc/2379-5077ABSTRACT Rational microbiome-based therapies may one day treat a wide range of diseases and promote wellness. Yet, we are still limited in our abilities to employ such therapies and to predict which bacterial strains have the potential to stably colonize a person. The Lieberman laboratory is working to close this knowledge gap and to develop an understanding of how individual species and strains behave in the human microbiome, including with regard to their niche ranges, survival strategies, and the degree to which they adapt to individual people. We employ system-level approaches, with a particular emphasis on using de novo mutations and evolutionary inference to reconstruct the history of bacterial lineages within individuals.Tami D. LiebermanAmerican Society for Microbiologyarticleevolutionhuman microbiomemicrobial ecologywithin-person evolutionevolutionary biologygenomicsMicrobiologyQR1-502ENmSystems, Vol 3, Iss 2 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	evolution human microbiome microbial ecology within-person evolution evolutionary biology genomics Microbiology QR1-502
spellingShingle	evolution human microbiome microbial ecology within-person evolution evolutionary biology genomics Microbiology QR1-502 Tami D. Lieberman Seven Billion Microcosms: Evolution within Human Microbiomes
description	ABSTRACT Rational microbiome-based therapies may one day treat a wide range of diseases and promote wellness. Yet, we are still limited in our abilities to employ such therapies and to predict which bacterial strains have the potential to stably colonize a person. The Lieberman laboratory is working to close this knowledge gap and to develop an understanding of how individual species and strains behave in the human microbiome, including with regard to their niche ranges, survival strategies, and the degree to which they adapt to individual people. We employ system-level approaches, with a particular emphasis on using de novo mutations and evolutionary inference to reconstruct the history of bacterial lineages within individuals.
format	article
author	Tami D. Lieberman
author_facet	Tami D. Lieberman
author_sort	Tami D. Lieberman
title	Seven Billion Microcosms: Evolution within Human Microbiomes
title_short	Seven Billion Microcosms: Evolution within Human Microbiomes
title_full	Seven Billion Microcosms: Evolution within Human Microbiomes
title_fullStr	Seven Billion Microcosms: Evolution within Human Microbiomes
title_full_unstemmed	Seven Billion Microcosms: Evolution within Human Microbiomes
title_sort	seven billion microcosms: evolution within human microbiomes
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/4435100d30b6480484c06c0e855c705d
work_keys_str_mv	AT tamidlieberman sevenbillionmicrocosmsevolutionwithinhumanmicrobiomes
_version_	1718375956463222784

Seven Billion Microcosms: Evolution within Human Microbiomes

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