Maturation of the preterm gastrointestinal tract can be defined by host and microbial markers for digestion and barrier defense

Abstract Functionality of the gastrointestinal tract is essential for growth and development of newborns. Preterm infants have an immature gastrointestinal tract, which is a major challenge in neonatal care. This study aims to improve the understanding of gastrointestinal functionality and maturatio...

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Autores principales:	Jannie G. E. Henderickx, Romy D. Zwittink, Ingrid B. Renes, Richard A. van Lingen, Diny van Zoeren-Grobben, Liesbeth J. Groot Jebbink, Sjef Boeren, Ruurd M. van Elburg, Jan Knol, Clara Belzer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4436859436c040b399c7cbc8420a2136
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spelling	oai:doaj.org-article:4436859436c040b399c7cbc8420a21362021-12-02T17:40:46ZMaturation of the preterm gastrointestinal tract can be defined by host and microbial markers for digestion and barrier defense10.1038/s41598-021-92222-y2045-2322https://doaj.org/article/4436859436c040b399c7cbc8420a21362021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92222-yhttps://doaj.org/toc/2045-2322Abstract Functionality of the gastrointestinal tract is essential for growth and development of newborns. Preterm infants have an immature gastrointestinal tract, which is a major challenge in neonatal care. This study aims to improve the understanding of gastrointestinal functionality and maturation during the early life of preterm infants by means of gastrointestinal enzyme activity assays and metaproteomics. In this single-center, observational study, preterm infants born between 24 and 33 weeks (n = 40) and term infants born between 37 and 42 weeks (n = 3), who were admitted to Isala (Zwolle, the Netherlands), were studied. Enzyme activity analyses identified active proteases in gastric aspirates of preterm infants. Metaproteomics revealed human milk, digestive and immunological proteins in gastric aspirates of preterm infants and feces of preterm and term infants. The fecal proteome of preterm infants was deprived of gastrointestinal barrier-related proteins during the first six postnatal weeks compared to term infants. In preterm infants, bacterial oxidative stress proteins were increased compared to term infants and higher birth weight correlated to higher relative abundance of bifidobacterial proteins in postnatal week 3 to 6. Our findings indicate that gastrointestinal and beneficial microbial proteins involved in gastrointestinal maturity are associated with gestational and postnatal age.Jannie G. E. HenderickxRomy D. ZwittinkIngrid B. RenesRichard A. van LingenDiny van Zoeren-GrobbenLiesbeth J. Groot JebbinkSjef BoerenRuurd M. van ElburgJan KnolClara BelzerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jannie G. E. Henderickx Romy D. Zwittink Ingrid B. Renes Richard A. van Lingen Diny van Zoeren-Grobben Liesbeth J. Groot Jebbink Sjef Boeren Ruurd M. van Elburg Jan Knol Clara Belzer Maturation of the preterm gastrointestinal tract can be defined by host and microbial markers for digestion and barrier defense
description	Abstract Functionality of the gastrointestinal tract is essential for growth and development of newborns. Preterm infants have an immature gastrointestinal tract, which is a major challenge in neonatal care. This study aims to improve the understanding of gastrointestinal functionality and maturation during the early life of preterm infants by means of gastrointestinal enzyme activity assays and metaproteomics. In this single-center, observational study, preterm infants born between 24 and 33 weeks (n = 40) and term infants born between 37 and 42 weeks (n = 3), who were admitted to Isala (Zwolle, the Netherlands), were studied. Enzyme activity analyses identified active proteases in gastric aspirates of preterm infants. Metaproteomics revealed human milk, digestive and immunological proteins in gastric aspirates of preterm infants and feces of preterm and term infants. The fecal proteome of preterm infants was deprived of gastrointestinal barrier-related proteins during the first six postnatal weeks compared to term infants. In preterm infants, bacterial oxidative stress proteins were increased compared to term infants and higher birth weight correlated to higher relative abundance of bifidobacterial proteins in postnatal week 3 to 6. Our findings indicate that gastrointestinal and beneficial microbial proteins involved in gastrointestinal maturity are associated with gestational and postnatal age.
format	article
author	Jannie G. E. Henderickx Romy D. Zwittink Ingrid B. Renes Richard A. van Lingen Diny van Zoeren-Grobben Liesbeth J. Groot Jebbink Sjef Boeren Ruurd M. van Elburg Jan Knol Clara Belzer
author_facet	Jannie G. E. Henderickx Romy D. Zwittink Ingrid B. Renes Richard A. van Lingen Diny van Zoeren-Grobben Liesbeth J. Groot Jebbink Sjef Boeren Ruurd M. van Elburg Jan Knol Clara Belzer
author_sort	Jannie G. E. Henderickx
title	Maturation of the preterm gastrointestinal tract can be defined by host and microbial markers for digestion and barrier defense
title_short	Maturation of the preterm gastrointestinal tract can be defined by host and microbial markers for digestion and barrier defense
title_full	Maturation of the preterm gastrointestinal tract can be defined by host and microbial markers for digestion and barrier defense
title_fullStr	Maturation of the preterm gastrointestinal tract can be defined by host and microbial markers for digestion and barrier defense
title_full_unstemmed	Maturation of the preterm gastrointestinal tract can be defined by host and microbial markers for digestion and barrier defense
title_sort	maturation of the preterm gastrointestinal tract can be defined by host and microbial markers for digestion and barrier defense
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4436859436c040b399c7cbc8420a2136
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Maturation of the preterm gastrointestinal tract can be defined by host and microbial markers for digestion and barrier defense

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