Association of cerebral networks in resting state with sexual preference of homosexual men: a study of regional homogeneity and functional connectivity.

Recent imaging studies have shown that brain morphology and neural activity during sexual arousal differ between homosexual and heterosexual men. However, functional differences in neural networks at the resting state is unknown. The study is to characterize the association of homosexual preference...

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Autores principales:	Shaohua Hu, Dongrong Xu, Bradley S Peterson, Qidong Wang, Xiaofu He, Jianbo Hu, Xiaojun Xu, Ning Wei, Dan Long, Manli Huang, Weihua Zhou, Weijuan Xu, Minming Zhang, Yi Xu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/44370d482091488fa8c1c2f81bbf35e4
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spelling	oai:doaj.org-article:44370d482091488fa8c1c2f81bbf35e42021-11-18T07:52:28ZAssociation of cerebral networks in resting state with sexual preference of homosexual men: a study of regional homogeneity and functional connectivity.1932-620310.1371/journal.pone.0059426https://doaj.org/article/44370d482091488fa8c1c2f81bbf35e42013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23555670/?tool=EBIhttps://doaj.org/toc/1932-6203Recent imaging studies have shown that brain morphology and neural activity during sexual arousal differ between homosexual and heterosexual men. However, functional differences in neural networks at the resting state is unknown. The study is to characterize the association of homosexual preference with measures of regional homogeneity and functional connectivity in the resting state. Participants were 26 healthy homosexual men and 26 age-matched healthy heterosexual men in whom we collected echo planar magnetic resonance imaging data in the resting state. The sexual orientation was evaluated using the Kinsey Scale. We first assessed group differences in regional homogeneity and then, taking the identified differences as seed regions, we compared groups in measures of functional connectivity from those seeds. The behavioral significances of the differences in regional homogeneity and functional connectivity were assessed by examining their associations with Kinsey Scores. Homosexual participants showed significantly reduced regional homogeneity in the left inferior occipital gyrus, right middle occipital gyrus, right superior occipital gyrus, left cuneus, right precuneus, and increased regional homogeneity in rectal gyrus, bilateral midbrain, and left temporal lobe. Regional homogeneity correlated positively with Kinsey scores in the left inferior occipital gyrus. The homosexual group also showed reduced functional connectivity between left middle temporal gyrus, left supra-marginal gyrus, right cuneus and the seed region, i.e. left inferior occipital gyrus. Additionly, the connection between the left inferior occipital gyrus and right thalamus correlated positively with Kinsey scores. These differences in regional homogeneity and functional connectivity may contribute to a better understanding of the neural basis of male sexual orientation.Shaohua HuDongrong XuBradley S PetersonQidong WangXiaofu HeJianbo HuXiaojun XuNing WeiDan LongManli HuangWeihua ZhouWeijuan XuMinming ZhangYi XuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 3, p e59426 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shaohua Hu Dongrong Xu Bradley S Peterson Qidong Wang Xiaofu He Jianbo Hu Xiaojun Xu Ning Wei Dan Long Manli Huang Weihua Zhou Weijuan Xu Minming Zhang Yi Xu Association of cerebral networks in resting state with sexual preference of homosexual men: a study of regional homogeneity and functional connectivity.
description	Recent imaging studies have shown that brain morphology and neural activity during sexual arousal differ between homosexual and heterosexual men. However, functional differences in neural networks at the resting state is unknown. The study is to characterize the association of homosexual preference with measures of regional homogeneity and functional connectivity in the resting state. Participants were 26 healthy homosexual men and 26 age-matched healthy heterosexual men in whom we collected echo planar magnetic resonance imaging data in the resting state. The sexual orientation was evaluated using the Kinsey Scale. We first assessed group differences in regional homogeneity and then, taking the identified differences as seed regions, we compared groups in measures of functional connectivity from those seeds. The behavioral significances of the differences in regional homogeneity and functional connectivity were assessed by examining their associations with Kinsey Scores. Homosexual participants showed significantly reduced regional homogeneity in the left inferior occipital gyrus, right middle occipital gyrus, right superior occipital gyrus, left cuneus, right precuneus, and increased regional homogeneity in rectal gyrus, bilateral midbrain, and left temporal lobe. Regional homogeneity correlated positively with Kinsey scores in the left inferior occipital gyrus. The homosexual group also showed reduced functional connectivity between left middle temporal gyrus, left supra-marginal gyrus, right cuneus and the seed region, i.e. left inferior occipital gyrus. Additionly, the connection between the left inferior occipital gyrus and right thalamus correlated positively with Kinsey scores. These differences in regional homogeneity and functional connectivity may contribute to a better understanding of the neural basis of male sexual orientation.
format	article
author	Shaohua Hu Dongrong Xu Bradley S Peterson Qidong Wang Xiaofu He Jianbo Hu Xiaojun Xu Ning Wei Dan Long Manli Huang Weihua Zhou Weijuan Xu Minming Zhang Yi Xu
author_facet	Shaohua Hu Dongrong Xu Bradley S Peterson Qidong Wang Xiaofu He Jianbo Hu Xiaojun Xu Ning Wei Dan Long Manli Huang Weihua Zhou Weijuan Xu Minming Zhang Yi Xu
author_sort	Shaohua Hu
title	Association of cerebral networks in resting state with sexual preference of homosexual men: a study of regional homogeneity and functional connectivity.
title_short	Association of cerebral networks in resting state with sexual preference of homosexual men: a study of regional homogeneity and functional connectivity.
title_full	Association of cerebral networks in resting state with sexual preference of homosexual men: a study of regional homogeneity and functional connectivity.
title_fullStr	Association of cerebral networks in resting state with sexual preference of homosexual men: a study of regional homogeneity and functional connectivity.
title_full_unstemmed	Association of cerebral networks in resting state with sexual preference of homosexual men: a study of regional homogeneity and functional connectivity.
title_sort	association of cerebral networks in resting state with sexual preference of homosexual men: a study of regional homogeneity and functional connectivity.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/44370d482091488fa8c1c2f81bbf35e4
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Association of cerebral networks in resting state with sexual preference of homosexual men: a study of regional homogeneity and functional connectivity.

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