Disposable diaper overuse is associated with primary enuresis in children

Abstract This research investigated the association between prolonged disposable diaper (DD) wearing in infancy and primary enuresis (PNE). As a case–control study, we collected data from 376 children with enuresis and 379 healthy children who were sex- and age-matched at three tertiary care institu...

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Autores principales:	Xing Li, Jian Guo Wen, Tong Shen, Xiao Qing Yang, Song Xu Peng, Xi Zheng Wang, Hui Xie, Xing Dong Wu, Yu Kai Du
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4437a121ae144f33b3ab1d2debe451e7
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spelling	oai:doaj.org-article:4437a121ae144f33b3ab1d2debe451e72021-12-02T19:04:11ZDisposable diaper overuse is associated with primary enuresis in children10.1038/s41598-020-70195-82045-2322https://doaj.org/article/4437a121ae144f33b3ab1d2debe451e72020-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-70195-8https://doaj.org/toc/2045-2322Abstract This research investigated the association between prolonged disposable diaper (DD) wearing in infancy and primary enuresis (PNE). As a case–control study, we collected data from 376 children with enuresis and 379 healthy children who were sex- and age-matched at three tertiary care institutions in mainland China from August 2017 to July 2018. The results of adjusted logistic regression showed the odds ratios (95% confidence intervals) for PNE across the categories of age of daytime DD use cessation were as follows: ≥ 25 months: 1.00, 18–24 months: 0.25 (0.17–0.37), and ≤ 17 months: 0.11 (0.06–0.20), independent of age, mother education, residence, toilet training approach, breastfeeding duration, UTI, constipation, anaphylactic disease and family history. After a similar multivariable adjustment, increased age of daytime DD use (per-month) had a positive correlation with PNE, OR = 1.17, 95% CI 1.13–1.20 and non-linear relationship was detected, whose point was 21 months (the effect sizes and the 95%CI on the left and right sides of inflection point were 1.04 (0.99–1.10), P = 0.131 and 1.25 (1.18–1.31), P < 0.001). Subgroup analysis found that the effect of duration of disposable diaper exposure for each additional month, those children had accepted assisted infant toilet training/elimination communication (AITT/EC) practice had a lower risk of PNE (OR = 1.08, 95% CI 1.04–1.12), compared with those without AITT/EC practice (OR = 1.20, 95% CI 1.14–1.27), P for interaction < 0.001. In conclusion, the children diagnosed with primary enuresis after age 5 stopped using disposable diapers at daytime later than the control group. Association between duration of DD exposure and the risk of childhood enuresis is modified by AITT/EC practice. Timely cessation use of disposable diaper and practice AITT/EC may shorten the time to nocturnal continence, and the prospective cohort studies are needed to verify the discoveries.Xing LiJian Guo WenTong ShenXiao Qing YangSong Xu PengXi Zheng WangHui XieXing Dong WuYu Kai DuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xing Li Jian Guo Wen Tong Shen Xiao Qing Yang Song Xu Peng Xi Zheng Wang Hui Xie Xing Dong Wu Yu Kai Du Disposable diaper overuse is associated with primary enuresis in children
description	Abstract This research investigated the association between prolonged disposable diaper (DD) wearing in infancy and primary enuresis (PNE). As a case–control study, we collected data from 376 children with enuresis and 379 healthy children who were sex- and age-matched at three tertiary care institutions in mainland China from August 2017 to July 2018. The results of adjusted logistic regression showed the odds ratios (95% confidence intervals) for PNE across the categories of age of daytime DD use cessation were as follows: ≥ 25 months: 1.00, 18–24 months: 0.25 (0.17–0.37), and ≤ 17 months: 0.11 (0.06–0.20), independent of age, mother education, residence, toilet training approach, breastfeeding duration, UTI, constipation, anaphylactic disease and family history. After a similar multivariable adjustment, increased age of daytime DD use (per-month) had a positive correlation with PNE, OR = 1.17, 95% CI 1.13–1.20 and non-linear relationship was detected, whose point was 21 months (the effect sizes and the 95%CI on the left and right sides of inflection point were 1.04 (0.99–1.10), P = 0.131 and 1.25 (1.18–1.31), P < 0.001). Subgroup analysis found that the effect of duration of disposable diaper exposure for each additional month, those children had accepted assisted infant toilet training/elimination communication (AITT/EC) practice had a lower risk of PNE (OR = 1.08, 95% CI 1.04–1.12), compared with those without AITT/EC practice (OR = 1.20, 95% CI 1.14–1.27), P for interaction < 0.001. In conclusion, the children diagnosed with primary enuresis after age 5 stopped using disposable diapers at daytime later than the control group. Association between duration of DD exposure and the risk of childhood enuresis is modified by AITT/EC practice. Timely cessation use of disposable diaper and practice AITT/EC may shorten the time to nocturnal continence, and the prospective cohort studies are needed to verify the discoveries.
format	article
author	Xing Li Jian Guo Wen Tong Shen Xiao Qing Yang Song Xu Peng Xi Zheng Wang Hui Xie Xing Dong Wu Yu Kai Du
author_facet	Xing Li Jian Guo Wen Tong Shen Xiao Qing Yang Song Xu Peng Xi Zheng Wang Hui Xie Xing Dong Wu Yu Kai Du
author_sort	Xing Li
title	Disposable diaper overuse is associated with primary enuresis in children
title_short	Disposable diaper overuse is associated with primary enuresis in children
title_full	Disposable diaper overuse is associated with primary enuresis in children
title_fullStr	Disposable diaper overuse is associated with primary enuresis in children
title_full_unstemmed	Disposable diaper overuse is associated with primary enuresis in children
title_sort	disposable diaper overuse is associated with primary enuresis in children
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/4437a121ae144f33b3ab1d2debe451e7
work_keys_str_mv	AT xingli disposablediaperoveruseisassociatedwithprimaryenuresisinchildren AT jianguowen disposablediaperoveruseisassociatedwithprimaryenuresisinchildren AT tongshen disposablediaperoveruseisassociatedwithprimaryenuresisinchildren AT xiaoqingyang disposablediaperoveruseisassociatedwithprimaryenuresisinchildren AT songxupeng disposablediaperoveruseisassociatedwithprimaryenuresisinchildren AT xizhengwang disposablediaperoveruseisassociatedwithprimaryenuresisinchildren AT huixie disposablediaperoveruseisassociatedwithprimaryenuresisinchildren AT xingdongwu disposablediaperoveruseisassociatedwithprimaryenuresisinchildren AT yukaidu disposablediaperoveruseisassociatedwithprimaryenuresisinchildren
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Disposable diaper overuse is associated with primary enuresis in children

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