Prevalence of primary open angle glaucoma in the last 20 years: a meta-analysis and systematic review

Abstract Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness in the world and is influenced by various sociodemographic factors. This meta-analysis aims to determine the worldwide prevalence of POAG in the adult general population for the last 20 years, and explore variat...

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Autores principales:	Nan Zhang, Jiaxing Wang, Ying Li, Bing Jiang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/443a62b6dd604670835ad1f1be72b192
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spelling	oai:doaj.org-article:443a62b6dd604670835ad1f1be72b1922021-12-02T14:33:57ZPrevalence of primary open angle glaucoma in the last 20 years: a meta-analysis and systematic review10.1038/s41598-021-92971-w2045-2322https://doaj.org/article/443a62b6dd604670835ad1f1be72b1922021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92971-whttps://doaj.org/toc/2045-2322Abstract Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness in the world and is influenced by various sociodemographic factors. This meta-analysis aims to determine the worldwide prevalence of POAG in the adult general population for the last 20 years, and explore variation in prevalence by age, gender and geographical location. An electronic literature search was performed using the PubMed, Embase, and Web of Science databases. Population-based cross-sectional or cohort studies published in the last 20 years (2000–2020) that reported prevalence of POAG were recruited. Relevant studies meeting defined eligibility criteria were selected and reviewed systematically by meta-analysis. The prevalence of POAG was analyzed according to various risk factors. A random effect model was used for the meta-analysis. Fifty publications with a total of 198,259 subjects were included in this meta-analysis. The worldwide overall prevalence of POAG was 2.4% (95% CI 2.0 ~ 2.8%). The prevalence increases with age. Men are found to be more susceptible to POAG than women (RR 1.28, p < 0.01). Africa is found to have the highest prevalence of POAG (4.0%) among all continents. The current estimated global population of POAG is 68.56 million (95% CI 59.99 ~ 79.98). POAG is a worldwide vision threatening disease with high prevalence for the last 20 years. The population-based prevalence of POAG varies widely across individual studies, due to variations in risk factors of age, gender, and population geographic location.Nan ZhangJiaxing WangYing LiBing JiangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nan Zhang Jiaxing Wang Ying Li Bing Jiang Prevalence of primary open angle glaucoma in the last 20 years: a meta-analysis and systematic review
description	Abstract Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness in the world and is influenced by various sociodemographic factors. This meta-analysis aims to determine the worldwide prevalence of POAG in the adult general population for the last 20 years, and explore variation in prevalence by age, gender and geographical location. An electronic literature search was performed using the PubMed, Embase, and Web of Science databases. Population-based cross-sectional or cohort studies published in the last 20 years (2000–2020) that reported prevalence of POAG were recruited. Relevant studies meeting defined eligibility criteria were selected and reviewed systematically by meta-analysis. The prevalence of POAG was analyzed according to various risk factors. A random effect model was used for the meta-analysis. Fifty publications with a total of 198,259 subjects were included in this meta-analysis. The worldwide overall prevalence of POAG was 2.4% (95% CI 2.0 ~ 2.8%). The prevalence increases with age. Men are found to be more susceptible to POAG than women (RR 1.28, p < 0.01). Africa is found to have the highest prevalence of POAG (4.0%) among all continents. The current estimated global population of POAG is 68.56 million (95% CI 59.99 ~ 79.98). POAG is a worldwide vision threatening disease with high prevalence for the last 20 years. The population-based prevalence of POAG varies widely across individual studies, due to variations in risk factors of age, gender, and population geographic location.
format	article
author	Nan Zhang Jiaxing Wang Ying Li Bing Jiang
author_facet	Nan Zhang Jiaxing Wang Ying Li Bing Jiang
author_sort	Nan Zhang
title	Prevalence of primary open angle glaucoma in the last 20 years: a meta-analysis and systematic review
title_short	Prevalence of primary open angle glaucoma in the last 20 years: a meta-analysis and systematic review
title_full	Prevalence of primary open angle glaucoma in the last 20 years: a meta-analysis and systematic review
title_fullStr	Prevalence of primary open angle glaucoma in the last 20 years: a meta-analysis and systematic review
title_full_unstemmed	Prevalence of primary open angle glaucoma in the last 20 years: a meta-analysis and systematic review
title_sort	prevalence of primary open angle glaucoma in the last 20 years: a meta-analysis and systematic review
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/443a62b6dd604670835ad1f1be72b192
work_keys_str_mv	AT nanzhang prevalenceofprimaryopenangleglaucomainthelast20yearsametaanalysisandsystematicreview AT jiaxingwang prevalenceofprimaryopenangleglaucomainthelast20yearsametaanalysisandsystematicreview AT yingli prevalenceofprimaryopenangleglaucomainthelast20yearsametaanalysisandsystematicreview AT bingjiang prevalenceofprimaryopenangleglaucomainthelast20yearsametaanalysisandsystematicreview
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Prevalence of primary open angle glaucoma in the last 20 years: a meta-analysis and systematic review

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