Bub1 positions Mad1 close to KNL1 MELT repeats to promote checkpoint signalling

The spindle assembly checkpoint ensures correct chromosome segregation and relies on kinetochore localization of the Bub1 and Mad1/Mad2 checkpoint proteins. Here the authors show that main function of Bub1 is to position Mad1 close to KNL1 MELT repeats in human cells.

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Autores principales:	Gang Zhang, Thomas Kruse, Blanca López-Méndez, Kathrine Beck Sylvestersen, Dimitriya H. Garvanska, Simone Schopper, Michael Lund Nielsen, Jakob Nilsson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/443aced42d614c6d811e9ee26b08fd00
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spelling	oai:doaj.org-article:443aced42d614c6d811e9ee26b08fd002021-12-02T15:38:42ZBub1 positions Mad1 close to KNL1 MELT repeats to promote checkpoint signalling10.1038/ncomms158222041-1723https://doaj.org/article/443aced42d614c6d811e9ee26b08fd002017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15822https://doaj.org/toc/2041-1723The spindle assembly checkpoint ensures correct chromosome segregation and relies on kinetochore localization of the Bub1 and Mad1/Mad2 checkpoint proteins. Here the authors show that main function of Bub1 is to position Mad1 close to KNL1 MELT repeats in human cells.Gang ZhangThomas KruseBlanca López-MéndezKathrine Beck SylvestersenDimitriya H. GarvanskaSimone SchopperMichael Lund NielsenJakob NilssonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gang Zhang Thomas Kruse Blanca López-Méndez Kathrine Beck Sylvestersen Dimitriya H. Garvanska Simone Schopper Michael Lund Nielsen Jakob Nilsson Bub1 positions Mad1 close to KNL1 MELT repeats to promote checkpoint signalling
description	The spindle assembly checkpoint ensures correct chromosome segregation and relies on kinetochore localization of the Bub1 and Mad1/Mad2 checkpoint proteins. Here the authors show that main function of Bub1 is to position Mad1 close to KNL1 MELT repeats in human cells.
format	article
author	Gang Zhang Thomas Kruse Blanca López-Méndez Kathrine Beck Sylvestersen Dimitriya H. Garvanska Simone Schopper Michael Lund Nielsen Jakob Nilsson
author_facet	Gang Zhang Thomas Kruse Blanca López-Méndez Kathrine Beck Sylvestersen Dimitriya H. Garvanska Simone Schopper Michael Lund Nielsen Jakob Nilsson
author_sort	Gang Zhang
title	Bub1 positions Mad1 close to KNL1 MELT repeats to promote checkpoint signalling
title_short	Bub1 positions Mad1 close to KNL1 MELT repeats to promote checkpoint signalling
title_full	Bub1 positions Mad1 close to KNL1 MELT repeats to promote checkpoint signalling
title_fullStr	Bub1 positions Mad1 close to KNL1 MELT repeats to promote checkpoint signalling
title_full_unstemmed	Bub1 positions Mad1 close to KNL1 MELT repeats to promote checkpoint signalling
title_sort	bub1 positions mad1 close to knl1 melt repeats to promote checkpoint signalling
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/443aced42d614c6d811e9ee26b08fd00
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Bub1 positions Mad1 close to KNL1 MELT repeats to promote checkpoint signalling

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