A mechanism for CO regulation of ion channels

Despite being highly toxic, carbon monoxide (CO) is also essential as an intracellular signalling molecule, but CO-dependent signalling is poorly understood. Here, authors employ spectroscopic and electrophysiology methods and find that CO activates KATP channels via SUR2A, a heme-regulated receptor...

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Autores principales:	Sofia M. Kapetanaki, Mark J. Burton, Jaswir Basran, Chiasa Uragami, Peter C. E. Moody, John S. Mitcheson, Ralf Schmid, Noel W. Davies, Pierre Dorlet, Marten H. Vos, Nina M. Storey, Emma Raven
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/443ba616a4bf488fa3708f48abac1594
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spelling	oai:doaj.org-article:443ba616a4bf488fa3708f48abac15942021-12-02T14:39:43ZA mechanism for CO regulation of ion channels10.1038/s41467-018-03291-z2041-1723https://doaj.org/article/443ba616a4bf488fa3708f48abac15942018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03291-zhttps://doaj.org/toc/2041-1723Despite being highly toxic, carbon monoxide (CO) is also essential as an intracellular signalling molecule, but CO-dependent signalling is poorly understood. Here, authors employ spectroscopic and electrophysiology methods and find that CO activates KATP channels via SUR2A, a heme-regulated receptor.Sofia M. KapetanakiMark J. BurtonJaswir BasranChiasa UragamiPeter C. E. MoodyJohn S. MitchesonRalf SchmidNoel W. DaviesPierre DorletMarten H. VosNina M. StoreyEmma RavenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sofia M. Kapetanaki Mark J. Burton Jaswir Basran Chiasa Uragami Peter C. E. Moody John S. Mitcheson Ralf Schmid Noel W. Davies Pierre Dorlet Marten H. Vos Nina M. Storey Emma Raven A mechanism for CO regulation of ion channels
description	Despite being highly toxic, carbon monoxide (CO) is also essential as an intracellular signalling molecule, but CO-dependent signalling is poorly understood. Here, authors employ spectroscopic and electrophysiology methods and find that CO activates KATP channels via SUR2A, a heme-regulated receptor.
format	article
author	Sofia M. Kapetanaki Mark J. Burton Jaswir Basran Chiasa Uragami Peter C. E. Moody John S. Mitcheson Ralf Schmid Noel W. Davies Pierre Dorlet Marten H. Vos Nina M. Storey Emma Raven
author_facet	Sofia M. Kapetanaki Mark J. Burton Jaswir Basran Chiasa Uragami Peter C. E. Moody John S. Mitcheson Ralf Schmid Noel W. Davies Pierre Dorlet Marten H. Vos Nina M. Storey Emma Raven
author_sort	Sofia M. Kapetanaki
title	A mechanism for CO regulation of ion channels
title_short	A mechanism for CO regulation of ion channels
title_full	A mechanism for CO regulation of ion channels
title_fullStr	A mechanism for CO regulation of ion channels
title_full_unstemmed	A mechanism for CO regulation of ion channels
title_sort	mechanism for co regulation of ion channels
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/443ba616a4bf488fa3708f48abac1594
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A mechanism for CO regulation of ion channels

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