Early-phase 18F-FP-CIT and 18F-flutemetamol PET were significantly correlated

Abstract Little is known about whether early-phase PET images of 18F-FP-CIT match those of amyloid PET. Here, we compared early-phase 18F-FP-CIT and 18F-flutemetamol PET images in patients who underwent both within a 1-month interval. The SUVR on early-phase 18F-FP-CIT PET (median, 0.86) was signifi...

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Autores principales:	Young-Sil An, Jung Han Yoon, Sang Joon Son, Chang Hyung Hong, Su Jin Lee, Joon-Kee Yoon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/443d4523aea340e4bdb9c19d6d58926e
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spelling	oai:doaj.org-article:443d4523aea340e4bdb9c19d6d58926e2021-12-02T17:52:22ZEarly-phase 18F-FP-CIT and 18F-flutemetamol PET were significantly correlated10.1038/s41598-021-91891-z2045-2322https://doaj.org/article/443d4523aea340e4bdb9c19d6d58926e2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91891-zhttps://doaj.org/toc/2045-2322Abstract Little is known about whether early-phase PET images of 18F-FP-CIT match those of amyloid PET. Here, we compared early-phase 18F-FP-CIT and 18F-flutemetamol PET images in patients who underwent both within a 1-month interval. The SUVR on early-phase 18F-FP-CIT PET (median, 0.86) was significantly lower than that of 18F-flutemetamol PET (median, 0.91, p < 0.001) for total brain regions including all cerebral lobes and central structures. This significant difference persisted for each brain region except central structures (p = 0.232). The SUVR of total brain regions obtained from early 18F-FP-CIT PET showed a very strong correlation with that of 18F-flutemetamol PET (rho = 0.80, p < 0.001). Among the kinetic parameters, only R1 showed a statistically significant correlation between the two techniques for all brain regions (rho = 0.89, p < 0.001). R1 from 18F-FP-CIT (median, 0.77) was significantly lower in all areas of the brain compared to R1 from 18F-flutemetamol PET (median, 0.81, p < 0.001).18F-FP-CIT demonstrated lower uptake in cortical brain regions than 18F-flutemetamol on early-phase PET. However, both early-phase PETs demonstrated significant correlation of uptake.Young-Sil AnJung Han YoonSang Joon SonChang Hyung HongSu Jin LeeJoon-Kee YoonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Young-Sil An Jung Han Yoon Sang Joon Son Chang Hyung Hong Su Jin Lee Joon-Kee Yoon Early-phase 18F-FP-CIT and 18F-flutemetamol PET were significantly correlated
description	Abstract Little is known about whether early-phase PET images of 18F-FP-CIT match those of amyloid PET. Here, we compared early-phase 18F-FP-CIT and 18F-flutemetamol PET images in patients who underwent both within a 1-month interval. The SUVR on early-phase 18F-FP-CIT PET (median, 0.86) was significantly lower than that of 18F-flutemetamol PET (median, 0.91, p < 0.001) for total brain regions including all cerebral lobes and central structures. This significant difference persisted for each brain region except central structures (p = 0.232). The SUVR of total brain regions obtained from early 18F-FP-CIT PET showed a very strong correlation with that of 18F-flutemetamol PET (rho = 0.80, p < 0.001). Among the kinetic parameters, only R1 showed a statistically significant correlation between the two techniques for all brain regions (rho = 0.89, p < 0.001). R1 from 18F-FP-CIT (median, 0.77) was significantly lower in all areas of the brain compared to R1 from 18F-flutemetamol PET (median, 0.81, p < 0.001).18F-FP-CIT demonstrated lower uptake in cortical brain regions than 18F-flutemetamol on early-phase PET. However, both early-phase PETs demonstrated significant correlation of uptake.
format	article
author	Young-Sil An Jung Han Yoon Sang Joon Son Chang Hyung Hong Su Jin Lee Joon-Kee Yoon
author_facet	Young-Sil An Jung Han Yoon Sang Joon Son Chang Hyung Hong Su Jin Lee Joon-Kee Yoon
author_sort	Young-Sil An
title	Early-phase 18F-FP-CIT and 18F-flutemetamol PET were significantly correlated
title_short	Early-phase 18F-FP-CIT and 18F-flutemetamol PET were significantly correlated
title_full	Early-phase 18F-FP-CIT and 18F-flutemetamol PET were significantly correlated
title_fullStr	Early-phase 18F-FP-CIT and 18F-flutemetamol PET were significantly correlated
title_full_unstemmed	Early-phase 18F-FP-CIT and 18F-flutemetamol PET were significantly correlated
title_sort	early-phase 18f-fp-cit and 18f-flutemetamol pet were significantly correlated
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/443d4523aea340e4bdb9c19d6d58926e
work_keys_str_mv	AT youngsilan earlyphase18ffpcitand18fflutemetamolpetweresignificantlycorrelated AT junghanyoon earlyphase18ffpcitand18fflutemetamolpetweresignificantlycorrelated AT sangjoonson earlyphase18ffpcitand18fflutemetamolpetweresignificantlycorrelated AT changhyunghong earlyphase18ffpcitand18fflutemetamolpetweresignificantlycorrelated AT sujinlee earlyphase18ffpcitand18fflutemetamolpetweresignificantlycorrelated AT joonkeeyoon earlyphase18ffpcitand18fflutemetamolpetweresignificantlycorrelated
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Early-phase 18F-FP-CIT and 18F-flutemetamol PET were significantly correlated

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