D-cycloserine in prelimbic cortex reverses scopolamine-induced deficits in olfactory memory in rats.

A significant interaction between N-methyl-D-aspartate (NMDA) and muscarinic receptors has been suggested in the modulation of learning and memory processes. The present study further investigates this issue and explores whether d-cycloserine (DCS), a partial agonist at the glycine binding site of t...

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Autores principales:	Marta Portero-Tresserra, Paula Cristóbal-Narváez, Margarita Martí-Nicolovius, Gemma Guillazo-Blanch, Anna Vale-Martínez
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/443e0ac753e94a38b3faee55a8d7b765
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spelling	oai:doaj.org-article:443e0ac753e94a38b3faee55a8d7b7652021-11-18T09:01:31ZD-cycloserine in prelimbic cortex reverses scopolamine-induced deficits in olfactory memory in rats.1932-620310.1371/journal.pone.0070584https://doaj.org/article/443e0ac753e94a38b3faee55a8d7b7652013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23936452/?tool=EBIhttps://doaj.org/toc/1932-6203A significant interaction between N-methyl-D-aspartate (NMDA) and muscarinic receptors has been suggested in the modulation of learning and memory processes. The present study further investigates this issue and explores whether d-cycloserine (DCS), a partial agonist at the glycine binding site of the NMDA receptors that has been regarded as a cognitive enhancer, would reverse scopolamine (SCOP)-induced amnesia in two olfactory learning tasks when administered into the prelimbic cortex (PLC). Thus, in experiment 1, DCS (10 µg/site) was infused prior to acquisition of odor discrimination (ODT) and social transmission of food preference (STFP), which have been previously characterized as paradigms sensitive to PLC muscarinic blockade. Immediately after learning such tasks, SCOP was injected (20 µg/site) and the effects of both drugs (alone and combined) were tested in 24-h retention tests. To assess whether DCS effects may depend on the difficulty of the task, in the STFP the rats expressed their food preference either in a standard two-choice test (experiment 1) or a more challenging three-choice test (experiment 2). The results showed that bilateral intra-PLC infusions of SCOP markedly disrupted the ODT and STFP memory tests. Additionally, infusions of DCS alone into the PLC enhanced ODT but not STFP retention. However, the DCS treatment reversed SCOP-induced memory deficits in both tasks, and this effect seemed more apparent in ODT and 3-choice STFP. Such results support the interaction between the glutamatergic and the cholinergic systems in the PLC in such a way that positive modulation of the NMDA receptor/channel, through activation of the glycine binding site, may compensate dysfunction of muscarinic neurotransmission involved in stimulus-reward and relational learning tasks.Marta Portero-TresserraPaula Cristóbal-NarváezMargarita Martí-NicoloviusGemma Guillazo-BlanchAnna Vale-MartínezPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 8, p e70584 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marta Portero-Tresserra Paula Cristóbal-Narváez Margarita Martí-Nicolovius Gemma Guillazo-Blanch Anna Vale-Martínez D-cycloserine in prelimbic cortex reverses scopolamine-induced deficits in olfactory memory in rats.
description	A significant interaction between N-methyl-D-aspartate (NMDA) and muscarinic receptors has been suggested in the modulation of learning and memory processes. The present study further investigates this issue and explores whether d-cycloserine (DCS), a partial agonist at the glycine binding site of the NMDA receptors that has been regarded as a cognitive enhancer, would reverse scopolamine (SCOP)-induced amnesia in two olfactory learning tasks when administered into the prelimbic cortex (PLC). Thus, in experiment 1, DCS (10 µg/site) was infused prior to acquisition of odor discrimination (ODT) and social transmission of food preference (STFP), which have been previously characterized as paradigms sensitive to PLC muscarinic blockade. Immediately after learning such tasks, SCOP was injected (20 µg/site) and the effects of both drugs (alone and combined) were tested in 24-h retention tests. To assess whether DCS effects may depend on the difficulty of the task, in the STFP the rats expressed their food preference either in a standard two-choice test (experiment 1) or a more challenging three-choice test (experiment 2). The results showed that bilateral intra-PLC infusions of SCOP markedly disrupted the ODT and STFP memory tests. Additionally, infusions of DCS alone into the PLC enhanced ODT but not STFP retention. However, the DCS treatment reversed SCOP-induced memory deficits in both tasks, and this effect seemed more apparent in ODT and 3-choice STFP. Such results support the interaction between the glutamatergic and the cholinergic systems in the PLC in such a way that positive modulation of the NMDA receptor/channel, through activation of the glycine binding site, may compensate dysfunction of muscarinic neurotransmission involved in stimulus-reward and relational learning tasks.
format	article
author	Marta Portero-Tresserra Paula Cristóbal-Narváez Margarita Martí-Nicolovius Gemma Guillazo-Blanch Anna Vale-Martínez
author_facet	Marta Portero-Tresserra Paula Cristóbal-Narváez Margarita Martí-Nicolovius Gemma Guillazo-Blanch Anna Vale-Martínez
author_sort	Marta Portero-Tresserra
title	D-cycloserine in prelimbic cortex reverses scopolamine-induced deficits in olfactory memory in rats.
title_short	D-cycloserine in prelimbic cortex reverses scopolamine-induced deficits in olfactory memory in rats.
title_full	D-cycloserine in prelimbic cortex reverses scopolamine-induced deficits in olfactory memory in rats.
title_fullStr	D-cycloserine in prelimbic cortex reverses scopolamine-induced deficits in olfactory memory in rats.
title_full_unstemmed	D-cycloserine in prelimbic cortex reverses scopolamine-induced deficits in olfactory memory in rats.
title_sort	d-cycloserine in prelimbic cortex reverses scopolamine-induced deficits in olfactory memory in rats.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/443e0ac753e94a38b3faee55a8d7b765
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D-cycloserine in prelimbic cortex reverses scopolamine-induced deficits in olfactory memory in rats.

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