Toward Personalized Control of Human Gut Bacterial Communities

ABSTRACT A key challenge in microbiology will be developing tools for manipulating human gut bacterial communities. Our ability to predict and control the dynamics of these communities is now in its infancy. To manage human gut microbiota, I am developing methods in three research domains. First, I...

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Autor principal:	Lawrence A. David
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	human microbiome microbiome engineering systems biology Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/443e793e4c174b2d9d32975df784f159
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spelling	oai:doaj.org-article:443e793e4c174b2d9d32975df784f1592021-12-02T19:47:34ZToward Personalized Control of Human Gut Bacterial Communities10.1128/mSystems.00165-172379-5077https://doaj.org/article/443e793e4c174b2d9d32975df784f1592018-04-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00165-17https://doaj.org/toc/2379-5077ABSTRACT A key challenge in microbiology will be developing tools for manipulating human gut bacterial communities. Our ability to predict and control the dynamics of these communities is now in its infancy. To manage human gut microbiota, I am developing methods in three research domains. First, I am refining in vitro tools to experimentally study gut microbes at high throughput and in controlled settings. Second, I am adapting “big data” techniques to overcome statistical challenges confronting microbiota modeling. Third, I am testing study designs that can streamline human testing of microbiota manipulations. Assembling these methods creates new challenges, including training scientists who can work across disciplines such as engineering, ecology, and medicine. Nevertheless, I envision that overcoming these obstacles will enable my group to construct platforms that can personalize microbiota treatments, particularly ones based on diet. More broadly, I anticipate that such platforms will have applications across fields such as agriculture, biotechnology, and environmental management.Lawrence A. DavidAmerican Society for Microbiologyarticlehuman microbiomemicrobiome engineeringsystems biologyMicrobiologyQR1-502ENmSystems, Vol 3, Iss 2 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	human microbiome microbiome engineering systems biology Microbiology QR1-502
spellingShingle	human microbiome microbiome engineering systems biology Microbiology QR1-502 Lawrence A. David Toward Personalized Control of Human Gut Bacterial Communities
description	ABSTRACT A key challenge in microbiology will be developing tools for manipulating human gut bacterial communities. Our ability to predict and control the dynamics of these communities is now in its infancy. To manage human gut microbiota, I am developing methods in three research domains. First, I am refining in vitro tools to experimentally study gut microbes at high throughput and in controlled settings. Second, I am adapting “big data” techniques to overcome statistical challenges confronting microbiota modeling. Third, I am testing study designs that can streamline human testing of microbiota manipulations. Assembling these methods creates new challenges, including training scientists who can work across disciplines such as engineering, ecology, and medicine. Nevertheless, I envision that overcoming these obstacles will enable my group to construct platforms that can personalize microbiota treatments, particularly ones based on diet. More broadly, I anticipate that such platforms will have applications across fields such as agriculture, biotechnology, and environmental management.
format	article
author	Lawrence A. David
author_facet	Lawrence A. David
author_sort	Lawrence A. David
title	Toward Personalized Control of Human Gut Bacterial Communities
title_short	Toward Personalized Control of Human Gut Bacterial Communities
title_full	Toward Personalized Control of Human Gut Bacterial Communities
title_fullStr	Toward Personalized Control of Human Gut Bacterial Communities
title_full_unstemmed	Toward Personalized Control of Human Gut Bacterial Communities
title_sort	toward personalized control of human gut bacterial communities
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/443e793e4c174b2d9d32975df784f159
work_keys_str_mv	AT lawrenceadavid towardpersonalizedcontrolofhumangutbacterialcommunities
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Toward Personalized Control of Human Gut Bacterial Communities

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