Fatty Acid Synthase induced S6Kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in DLBCL

Aberrant protein translation and uncontrolled lipid metabolism are hallmarks of cancer growth. Here, in diffuse large B-cell lymphoma, the authors show that fatty acid synthase increases USP11 interaction with and stability of eIF4B via PI3K-S6Kinase signaling, promoting oncogenic protein translatio...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Bandish Kapadia, Nahid M. Nanaji, Kavita Bhalla, Binny Bhandary, Rena Lapidus, Afshin Beheshti, Andrew M. Evens, Ronald B. Gartenhaus
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4442d9e37eba405d90872facca4c28df
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4442d9e37eba405d90872facca4c28df
record_format	dspace
spelling	oai:doaj.org-article:4442d9e37eba405d90872facca4c28df2021-12-02T17:32:01ZFatty Acid Synthase induced S6Kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in DLBCL10.1038/s41467-018-03028-y2041-1723https://doaj.org/article/4442d9e37eba405d90872facca4c28df2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03028-yhttps://doaj.org/toc/2041-1723Aberrant protein translation and uncontrolled lipid metabolism are hallmarks of cancer growth. Here, in diffuse large B-cell lymphoma, the authors show that fatty acid synthase increases USP11 interaction with and stability of eIF4B via PI3K-S6Kinase signaling, promoting oncogenic protein translation.Bandish KapadiaNahid M. NanajiKavita BhallaBinny BhandaryRena LapidusAfshin BeheshtiAndrew M. EvensRonald B. GartenhausNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bandish Kapadia Nahid M. Nanaji Kavita Bhalla Binny Bhandary Rena Lapidus Afshin Beheshti Andrew M. Evens Ronald B. Gartenhaus Fatty Acid Synthase induced S6Kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in DLBCL
description	Aberrant protein translation and uncontrolled lipid metabolism are hallmarks of cancer growth. Here, in diffuse large B-cell lymphoma, the authors show that fatty acid synthase increases USP11 interaction with and stability of eIF4B via PI3K-S6Kinase signaling, promoting oncogenic protein translation.
format	article
author	Bandish Kapadia Nahid M. Nanaji Kavita Bhalla Binny Bhandary Rena Lapidus Afshin Beheshti Andrew M. Evens Ronald B. Gartenhaus
author_facet	Bandish Kapadia Nahid M. Nanaji Kavita Bhalla Binny Bhandary Rena Lapidus Afshin Beheshti Andrew M. Evens Ronald B. Gartenhaus
author_sort	Bandish Kapadia
title	Fatty Acid Synthase induced S6Kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in DLBCL
title_short	Fatty Acid Synthase induced S6Kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in DLBCL
title_full	Fatty Acid Synthase induced S6Kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in DLBCL
title_fullStr	Fatty Acid Synthase induced S6Kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in DLBCL
title_full_unstemmed	Fatty Acid Synthase induced S6Kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in DLBCL
title_sort	fatty acid synthase induced s6kinase facilitates usp11-eif4b complex formation for sustained oncogenic translation in dlbcl
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/4442d9e37eba405d90872facca4c28df
work_keys_str_mv	AT bandishkapadia fattyacidsynthaseinduceds6kinasefacilitatesusp11eif4bcomplexformationforsustainedoncogenictranslationindlbcl AT nahidmnanaji fattyacidsynthaseinduceds6kinasefacilitatesusp11eif4bcomplexformationforsustainedoncogenictranslationindlbcl AT kavitabhalla fattyacidsynthaseinduceds6kinasefacilitatesusp11eif4bcomplexformationforsustainedoncogenictranslationindlbcl AT binnybhandary fattyacidsynthaseinduceds6kinasefacilitatesusp11eif4bcomplexformationforsustainedoncogenictranslationindlbcl AT renalapidus fattyacidsynthaseinduceds6kinasefacilitatesusp11eif4bcomplexformationforsustainedoncogenictranslationindlbcl AT afshinbeheshti fattyacidsynthaseinduceds6kinasefacilitatesusp11eif4bcomplexformationforsustainedoncogenictranslationindlbcl AT andrewmevens fattyacidsynthaseinduceds6kinasefacilitatesusp11eif4bcomplexformationforsustainedoncogenictranslationindlbcl AT ronaldbgartenhaus fattyacidsynthaseinduceds6kinasefacilitatesusp11eif4bcomplexformationforsustainedoncogenictranslationindlbcl
_version_	1718380426127474688

Fatty Acid Synthase induced S6Kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in DLBCL

Ejemplares similares