Clustering of Spontaneous Recurrent Seizures in a Mouse Model of Extended Hippocampal Kindling

Acute repetitive seizures or seizure clusters are common in epileptic patients. Seizure clusters are associated with a high risk of developing status epilepticus and increased morbidity and mortality. Seizure clusters are also recognizable in spontaneous recurrent seizures (SRS) that occur in animal...

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Autores principales:	Haiyu Liu, Liang Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	mice EEG spontaneous recurrent seizures kindling hippocampus epilepsy Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/44430354d9a14539bd9818711f1f588c
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spelling	oai:doaj.org-article:44430354d9a14539bd9818711f1f588c2021-11-30T20:58:32ZClustering of Spontaneous Recurrent Seizures in a Mouse Model of Extended Hippocampal Kindling1664-229510.3389/fneur.2021.738986https://doaj.org/article/44430354d9a14539bd9818711f1f588c2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fneur.2021.738986/fullhttps://doaj.org/toc/1664-2295Acute repetitive seizures or seizure clusters are common in epileptic patients. Seizure clusters are associated with a high risk of developing status epilepticus and increased morbidity and mortality. Seizure clusters are also recognizable in spontaneous recurrent seizures (SRS) that occur in animal models of epilepsy. The electrical kindling of a limbic structure is a commonly used model of temporal lobe epilepsy. Although classic kindling over the course of a few weeks does not generally induce SRS, extended kindling over the course of a few months can induce SRS in several animal species. SRS in kindled cats often occur in clusters, but the existence of seizure clusters in rodent models of extended kindling remains to be demonstrated. We explored the existence of seizure clusters in mice following extended hippocampal kindling. Adult male mice (C57BL/6) experienced twice daily hippocampal stimulations and underwent continuous 24-hour electroencephalogram (EEG)-video monitoring after ≥80 stimulations. SRS events were recognized by EEG discharges and associated motor seizures. Seizure clusters, defined as ≥4 seizures per cluster and intra-cluster inter-seizure intervals ≤ 120 min, were observed in 19 of the 20 kindled mice. Individual mice showed variable seizure clusters in terms of cluster incidence and circadian-like expression patterns. For clusters consisting of 4–7 seizures and intra-seizure intervals ≤ 20 min, no consistent changes in inter-seizure intervals, EEG discharge duration, or motor seizure severity scores were observed approaching cluster termination. These results suggested that seizure clustering represents a prominent feature of SRS in hippocampal kindled mice. We speculate that, despite experimental limitations and confounding factors, systemic homeostatic mechanisms that have yet to be explored may play an important role in governing the occurrence and termination of seizure clusters.Haiyu LiuHaiyu LiuLiang ZhangLiang ZhangFrontiers Media S.A.articlemiceEEGspontaneous recurrent seizureskindlinghippocampusepilepsyNeurology. Diseases of the nervous systemRC346-429ENFrontiers in Neurology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mice EEG spontaneous recurrent seizures kindling hippocampus epilepsy Neurology. Diseases of the nervous system RC346-429
spellingShingle	mice EEG spontaneous recurrent seizures kindling hippocampus epilepsy Neurology. Diseases of the nervous system RC346-429 Haiyu Liu Haiyu Liu Liang Zhang Liang Zhang Clustering of Spontaneous Recurrent Seizures in a Mouse Model of Extended Hippocampal Kindling
description	Acute repetitive seizures or seizure clusters are common in epileptic patients. Seizure clusters are associated with a high risk of developing status epilepticus and increased morbidity and mortality. Seizure clusters are also recognizable in spontaneous recurrent seizures (SRS) that occur in animal models of epilepsy. The electrical kindling of a limbic structure is a commonly used model of temporal lobe epilepsy. Although classic kindling over the course of a few weeks does not generally induce SRS, extended kindling over the course of a few months can induce SRS in several animal species. SRS in kindled cats often occur in clusters, but the existence of seizure clusters in rodent models of extended kindling remains to be demonstrated. We explored the existence of seizure clusters in mice following extended hippocampal kindling. Adult male mice (C57BL/6) experienced twice daily hippocampal stimulations and underwent continuous 24-hour electroencephalogram (EEG)-video monitoring after ≥80 stimulations. SRS events were recognized by EEG discharges and associated motor seizures. Seizure clusters, defined as ≥4 seizures per cluster and intra-cluster inter-seizure intervals ≤ 120 min, were observed in 19 of the 20 kindled mice. Individual mice showed variable seizure clusters in terms of cluster incidence and circadian-like expression patterns. For clusters consisting of 4–7 seizures and intra-seizure intervals ≤ 20 min, no consistent changes in inter-seizure intervals, EEG discharge duration, or motor seizure severity scores were observed approaching cluster termination. These results suggested that seizure clustering represents a prominent feature of SRS in hippocampal kindled mice. We speculate that, despite experimental limitations and confounding factors, systemic homeostatic mechanisms that have yet to be explored may play an important role in governing the occurrence and termination of seizure clusters.
format	article
author	Haiyu Liu Haiyu Liu Liang Zhang Liang Zhang
author_facet	Haiyu Liu Haiyu Liu Liang Zhang Liang Zhang
author_sort	Haiyu Liu
title	Clustering of Spontaneous Recurrent Seizures in a Mouse Model of Extended Hippocampal Kindling
title_short	Clustering of Spontaneous Recurrent Seizures in a Mouse Model of Extended Hippocampal Kindling
title_full	Clustering of Spontaneous Recurrent Seizures in a Mouse Model of Extended Hippocampal Kindling
title_fullStr	Clustering of Spontaneous Recurrent Seizures in a Mouse Model of Extended Hippocampal Kindling
title_full_unstemmed	Clustering of Spontaneous Recurrent Seizures in a Mouse Model of Extended Hippocampal Kindling
title_sort	clustering of spontaneous recurrent seizures in a mouse model of extended hippocampal kindling
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/44430354d9a14539bd9818711f1f588c
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Clustering of Spontaneous Recurrent Seizures in a Mouse Model of Extended Hippocampal Kindling

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