Variability in mRNA translation: a random matrix theory approach

Abstract The rate of mRNA translation depends on the initiation, elongation, and termination rates of ribosomes along the mRNA. These rates depend on many “local” factors like the abundance of free ribosomes and tRNA molecules in the vicinity of the mRNA molecule. All these factors are stochastic an...

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Autores principales:	Michael Margaliot, Wasim Huleihel, Tamir Tuller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/444da30749464f0a930644f1049d60c7
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spelling	oai:doaj.org-article:444da30749464f0a930644f1049d60c72021-12-02T15:53:02ZVariability in mRNA translation: a random matrix theory approach10.1038/s41598-021-84738-02045-2322https://doaj.org/article/444da30749464f0a930644f1049d60c72021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84738-0https://doaj.org/toc/2045-2322Abstract The rate of mRNA translation depends on the initiation, elongation, and termination rates of ribosomes along the mRNA. These rates depend on many “local” factors like the abundance of free ribosomes and tRNA molecules in the vicinity of the mRNA molecule. All these factors are stochastic and their experimental measurements are also noisy. An important question is how protein production in the cell is affected by this considerable variability. We develop a new theoretical framework for addressing this question by modeling the rates as identically and independently distributed random variables and using tools from random matrix theory to analyze the steady-state production rate. The analysis reveals a principle of universality: the average protein production rate depends only on the of the set of possible values that the random variable may attain. This explains how total protein production can be stabilized despite the overwhelming stochasticticity underlying cellular processes.Michael MargaliotWasim HuleihelTamir TullerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michael Margaliot Wasim Huleihel Tamir Tuller Variability in mRNA translation: a random matrix theory approach
description	Abstract The rate of mRNA translation depends on the initiation, elongation, and termination rates of ribosomes along the mRNA. These rates depend on many “local” factors like the abundance of free ribosomes and tRNA molecules in the vicinity of the mRNA molecule. All these factors are stochastic and their experimental measurements are also noisy. An important question is how protein production in the cell is affected by this considerable variability. We develop a new theoretical framework for addressing this question by modeling the rates as identically and independently distributed random variables and using tools from random matrix theory to analyze the steady-state production rate. The analysis reveals a principle of universality: the average protein production rate depends only on the of the set of possible values that the random variable may attain. This explains how total protein production can be stabilized despite the overwhelming stochasticticity underlying cellular processes.
format	article
author	Michael Margaliot Wasim Huleihel Tamir Tuller
author_facet	Michael Margaliot Wasim Huleihel Tamir Tuller
author_sort	Michael Margaliot
title	Variability in mRNA translation: a random matrix theory approach
title_short	Variability in mRNA translation: a random matrix theory approach
title_full	Variability in mRNA translation: a random matrix theory approach
title_fullStr	Variability in mRNA translation: a random matrix theory approach
title_full_unstemmed	Variability in mRNA translation: a random matrix theory approach
title_sort	variability in mrna translation: a random matrix theory approach
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/444da30749464f0a930644f1049d60c7
work_keys_str_mv	AT michaelmargaliot variabilityinmrnatranslationarandommatrixtheoryapproach AT wasimhuleihel variabilityinmrnatranslationarandommatrixtheoryapproach AT tamirtuller variabilityinmrnatranslationarandommatrixtheoryapproach
_version_	1718385506073444352

Variability in mRNA translation: a random matrix theory approach

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