The pause-initiation limit restricts transcription activation in human cells

Gene activation requires an increase of successful initiation events. Here, by employing a genome-wide kinetic analysis of transcription, the authors showed that gene activation generally requires a decrease in RNA Polymerase II (Pol II) promoter-proximal pausing while transcription of enhancer elem...

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Autores principales:	Saskia Gressel, Björn Schwalb, Patrick Cramer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/444dce082fe34f7a9a67503e677a5fb4
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spelling	oai:doaj.org-article:444dce082fe34f7a9a67503e677a5fb42021-12-02T17:02:08ZThe pause-initiation limit restricts transcription activation in human cells10.1038/s41467-019-11536-82041-1723https://doaj.org/article/444dce082fe34f7a9a67503e677a5fb42019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11536-8https://doaj.org/toc/2041-1723Gene activation requires an increase of successful initiation events. Here, by employing a genome-wide kinetic analysis of transcription, the authors showed that gene activation generally requires a decrease in RNA Polymerase II (Pol II) promoter-proximal pausing while transcription of enhancer elements is not limited by Pol II pausing.Saskia GresselBjörn SchwalbPatrick CramerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Saskia Gressel Björn Schwalb Patrick Cramer The pause-initiation limit restricts transcription activation in human cells
description	Gene activation requires an increase of successful initiation events. Here, by employing a genome-wide kinetic analysis of transcription, the authors showed that gene activation generally requires a decrease in RNA Polymerase II (Pol II) promoter-proximal pausing while transcription of enhancer elements is not limited by Pol II pausing.
format	article
author	Saskia Gressel Björn Schwalb Patrick Cramer
author_facet	Saskia Gressel Björn Schwalb Patrick Cramer
author_sort	Saskia Gressel
title	The pause-initiation limit restricts transcription activation in human cells
title_short	The pause-initiation limit restricts transcription activation in human cells
title_full	The pause-initiation limit restricts transcription activation in human cells
title_fullStr	The pause-initiation limit restricts transcription activation in human cells
title_full_unstemmed	The pause-initiation limit restricts transcription activation in human cells
title_sort	pause-initiation limit restricts transcription activation in human cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/444dce082fe34f7a9a67503e677a5fb4
work_keys_str_mv	AT saskiagressel thepauseinitiationlimitrestrictstranscriptionactivationinhumancells AT bjornschwalb thepauseinitiationlimitrestrictstranscriptionactivationinhumancells AT patrickcramer thepauseinitiationlimitrestrictstranscriptionactivationinhumancells AT saskiagressel pauseinitiationlimitrestrictstranscriptionactivationinhumancells AT bjornschwalb pauseinitiationlimitrestrictstranscriptionactivationinhumancells AT patrickcramer pauseinitiationlimitrestrictstranscriptionactivationinhumancells
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The pause-initiation limit restricts transcription activation in human cells

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