The pause-initiation limit restricts transcription activation in human cells

Gene activation requires an increase of successful initiation events. Here, by employing a genome-wide kinetic analysis of transcription, the authors showed that gene activation generally requires a decrease in RNA Polymerase II (Pol II) promoter-proximal pausing while transcription of enhancer elem...

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Autores principales: Saskia Gressel, Björn Schwalb, Patrick Cramer
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/444dce082fe34f7a9a67503e677a5fb4
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