Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight adipocyte biology

While many pleiotropic genetic loci have been identified, how they contribute to phenotypes across traits and diseases is unclear. Here, the authors propose decomposition of genetic associations (DeGAs), which uses singular value decomposition, to characterize the underlying latent structure of gene...

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Autores principales:	Yosuke Tanigawa, Jiehan Li, Johanne M. Justesen, Heiko Horn, Matthew Aguirre, Christopher DeBoever, Chris Chang, Balasubramanian Narasimhan, Kasper Lage, Trevor Hastie, Chong Y. Park, Gill Bejerano, Erik Ingelsson, Manuel A. Rivas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/444dcf6d4db4447e90c469502f9a36e5
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spelling	oai:doaj.org-article:444dcf6d4db4447e90c469502f9a36e52021-12-02T15:35:06ZComponents of genetic associations across 2,138 phenotypes in the UK Biobank highlight adipocyte biology10.1038/s41467-019-11953-92041-1723https://doaj.org/article/444dcf6d4db4447e90c469502f9a36e52019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11953-9https://doaj.org/toc/2041-1723While many pleiotropic genetic loci have been identified, how they contribute to phenotypes across traits and diseases is unclear. Here, the authors propose decomposition of genetic associations (DeGAs), which uses singular value decomposition, to characterize the underlying latent structure of genetic associations of 2,138 phenotypes.Yosuke TanigawaJiehan LiJohanne M. JustesenHeiko HornMatthew AguirreChristopher DeBoeverChris ChangBalasubramanian NarasimhanKasper LageTrevor HastieChong Y. ParkGill BejeranoErik IngelssonManuel A. RivasNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yosuke Tanigawa Jiehan Li Johanne M. Justesen Heiko Horn Matthew Aguirre Christopher DeBoever Chris Chang Balasubramanian Narasimhan Kasper Lage Trevor Hastie Chong Y. Park Gill Bejerano Erik Ingelsson Manuel A. Rivas Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight adipocyte biology
description	While many pleiotropic genetic loci have been identified, how they contribute to phenotypes across traits and diseases is unclear. Here, the authors propose decomposition of genetic associations (DeGAs), which uses singular value decomposition, to characterize the underlying latent structure of genetic associations of 2,138 phenotypes.
format	article
author	Yosuke Tanigawa Jiehan Li Johanne M. Justesen Heiko Horn Matthew Aguirre Christopher DeBoever Chris Chang Balasubramanian Narasimhan Kasper Lage Trevor Hastie Chong Y. Park Gill Bejerano Erik Ingelsson Manuel A. Rivas
author_facet	Yosuke Tanigawa Jiehan Li Johanne M. Justesen Heiko Horn Matthew Aguirre Christopher DeBoever Chris Chang Balasubramanian Narasimhan Kasper Lage Trevor Hastie Chong Y. Park Gill Bejerano Erik Ingelsson Manuel A. Rivas
author_sort	Yosuke Tanigawa
title	Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight adipocyte biology
title_short	Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight adipocyte biology
title_full	Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight adipocyte biology
title_fullStr	Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight adipocyte biology
title_full_unstemmed	Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight adipocyte biology
title_sort	components of genetic associations across 2,138 phenotypes in the uk biobank highlight adipocyte biology
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/444dcf6d4db4447e90c469502f9a36e5
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Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight adipocyte biology

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