A body shape index is associated with endothelial dysfunction in both men and women
Abstract A body shape index (ABSI) was proposed for estimation of abdominal adiposity. ABSI has been reported to have associations with cardiovascular risk factors and cardiovascular events. However, there is no information on the association between ABSI and endothelial function. We examined cross-...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/444e581b3d6a4b9dad2a0d9d497318ca |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:444e581b3d6a4b9dad2a0d9d497318ca |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:444e581b3d6a4b9dad2a0d9d497318ca2021-12-02T19:13:48ZA body shape index is associated with endothelial dysfunction in both men and women10.1038/s41598-021-97325-02045-2322https://doaj.org/article/444e581b3d6a4b9dad2a0d9d497318ca2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97325-0https://doaj.org/toc/2045-2322Abstract A body shape index (ABSI) was proposed for estimation of abdominal adiposity. ABSI has been reported to have associations with cardiovascular risk factors and cardiovascular events. However, there is no information on the association between ABSI and endothelial function. We examined cross-sectional associations of ABSI with endothelial function in 8823 subjects (6773 men and 2050 women). Subjects with a lower quartile of flow-mediated vasodilation (FMD) were defined as subjects having endothelial dysfunction. Pearson’s correlation coefficient analysis revealed that ABSI was negatively correlated with FMD (men, r = − 0.23, P = 0.003; women, r = − 0.32, P < 0.001). The areas under the curves of ABSI and body mass index to predict endothelial dysfunction were 0.64 (95% confidence interval [CI] 0.62–0.65) and 0.58 (95% CI 0.57–0.60) in men, and 0.68 (95% CI 0.66–0.71) and 0.59 (95% CI 0.56–0.61) in women, respectively. The cutoff values of ABSI for predicting subjects with endothelial dysfunction were 0.0796 (sensitivity, 55.2%; specificity, 65.5%) in men and 0.0823 (sensitivity, 56.2%; specificity, 73.4%) in women. Multivariate analysis revealed that an ABSI value higher than the cutoff value remained an independent predictor of endothelial dysfunction in both sexes. The results of our study suggest that ABSI calculation should be performed for evaluation of risk of cardiovascular events in both men and women. Clinical trial registration information URL for Clinical Trial: https://www.umin.ac.jp/ctr/index.htm ; Registration Number for Clinical Trial: UMIN000012952 (01/05/2010).Masato KajikawaTatsuya MaruhashiShinji KishimotoTakayuki YamajiTakahiro HaradaYu HashimotoYiming HanAya MizobuchiGaku AokiKenichi YoshimuraKazuaki ChayamaChikara GotoFarina Mohamad YusoffAyumu NakashimaYukihito HigashiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Masato Kajikawa Tatsuya Maruhashi Shinji Kishimoto Takayuki Yamaji Takahiro Harada Yu Hashimoto Yiming Han Aya Mizobuchi Gaku Aoki Kenichi Yoshimura Kazuaki Chayama Chikara Goto Farina Mohamad Yusoff Ayumu Nakashima Yukihito Higashi A body shape index is associated with endothelial dysfunction in both men and women |
| description |
Abstract A body shape index (ABSI) was proposed for estimation of abdominal adiposity. ABSI has been reported to have associations with cardiovascular risk factors and cardiovascular events. However, there is no information on the association between ABSI and endothelial function. We examined cross-sectional associations of ABSI with endothelial function in 8823 subjects (6773 men and 2050 women). Subjects with a lower quartile of flow-mediated vasodilation (FMD) were defined as subjects having endothelial dysfunction. Pearson’s correlation coefficient analysis revealed that ABSI was negatively correlated with FMD (men, r = − 0.23, P = 0.003; women, r = − 0.32, P < 0.001). The areas under the curves of ABSI and body mass index to predict endothelial dysfunction were 0.64 (95% confidence interval [CI] 0.62–0.65) and 0.58 (95% CI 0.57–0.60) in men, and 0.68 (95% CI 0.66–0.71) and 0.59 (95% CI 0.56–0.61) in women, respectively. The cutoff values of ABSI for predicting subjects with endothelial dysfunction were 0.0796 (sensitivity, 55.2%; specificity, 65.5%) in men and 0.0823 (sensitivity, 56.2%; specificity, 73.4%) in women. Multivariate analysis revealed that an ABSI value higher than the cutoff value remained an independent predictor of endothelial dysfunction in both sexes. The results of our study suggest that ABSI calculation should be performed for evaluation of risk of cardiovascular events in both men and women. Clinical trial registration information URL for Clinical Trial: https://www.umin.ac.jp/ctr/index.htm ; Registration Number for Clinical Trial: UMIN000012952 (01/05/2010). |
| format |
article |
| author |
Masato Kajikawa Tatsuya Maruhashi Shinji Kishimoto Takayuki Yamaji Takahiro Harada Yu Hashimoto Yiming Han Aya Mizobuchi Gaku Aoki Kenichi Yoshimura Kazuaki Chayama Chikara Goto Farina Mohamad Yusoff Ayumu Nakashima Yukihito Higashi |
| author_facet |
Masato Kajikawa Tatsuya Maruhashi Shinji Kishimoto Takayuki Yamaji Takahiro Harada Yu Hashimoto Yiming Han Aya Mizobuchi Gaku Aoki Kenichi Yoshimura Kazuaki Chayama Chikara Goto Farina Mohamad Yusoff Ayumu Nakashima Yukihito Higashi |
| author_sort |
Masato Kajikawa |
| title |
A body shape index is associated with endothelial dysfunction in both men and women |
| title_short |
A body shape index is associated with endothelial dysfunction in both men and women |
| title_full |
A body shape index is associated with endothelial dysfunction in both men and women |
| title_fullStr |
A body shape index is associated with endothelial dysfunction in both men and women |
| title_full_unstemmed |
A body shape index is associated with endothelial dysfunction in both men and women |
| title_sort |
body shape index is associated with endothelial dysfunction in both men and women |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/444e581b3d6a4b9dad2a0d9d497318ca |
| work_keys_str_mv |
AT masatokajikawa abodyshapeindexisassociatedwithendothelialdysfunctioninbothmenandwomen AT tatsuyamaruhashi abodyshapeindexisassociatedwithendothelialdysfunctioninbothmenandwomen AT shinjikishimoto abodyshapeindexisassociatedwithendothelialdysfunctioninbothmenandwomen AT takayukiyamaji abodyshapeindexisassociatedwithendothelialdysfunctioninbothmenandwomen AT takahiroharada abodyshapeindexisassociatedwithendothelialdysfunctioninbothmenandwomen AT yuhashimoto abodyshapeindexisassociatedwithendothelialdysfunctioninbothmenandwomen AT yiminghan abodyshapeindexisassociatedwithendothelialdysfunctioninbothmenandwomen AT ayamizobuchi abodyshapeindexisassociatedwithendothelialdysfunctioninbothmenandwomen AT gakuaoki abodyshapeindexisassociatedwithendothelialdysfunctioninbothmenandwomen AT kenichiyoshimura abodyshapeindexisassociatedwithendothelialdysfunctioninbothmenandwomen AT kazuakichayama abodyshapeindexisassociatedwithendothelialdysfunctioninbothmenandwomen AT chikaragoto abodyshapeindexisassociatedwithendothelialdysfunctioninbothmenandwomen AT farinamohamadyusoff abodyshapeindexisassociatedwithendothelialdysfunctioninbothmenandwomen AT ayumunakashima abodyshapeindexisassociatedwithendothelialdysfunctioninbothmenandwomen AT yukihitohigashi abodyshapeindexisassociatedwithendothelialdysfunctioninbothmenandwomen AT masatokajikawa bodyshapeindexisassociatedwithendothelialdysfunctioninbothmenandwomen AT tatsuyamaruhashi bodyshapeindexisassociatedwithendothelialdysfunctioninbothmenandwomen AT shinjikishimoto bodyshapeindexisassociatedwithendothelialdysfunctioninbothmenandwomen AT takayukiyamaji bodyshapeindexisassociatedwithendothelialdysfunctioninbothmenandwomen AT takahiroharada bodyshapeindexisassociatedwithendothelialdysfunctioninbothmenandwomen AT yuhashimoto bodyshapeindexisassociatedwithendothelialdysfunctioninbothmenandwomen AT yiminghan bodyshapeindexisassociatedwithendothelialdysfunctioninbothmenandwomen AT ayamizobuchi bodyshapeindexisassociatedwithendothelialdysfunctioninbothmenandwomen AT gakuaoki bodyshapeindexisassociatedwithendothelialdysfunctioninbothmenandwomen AT kenichiyoshimura bodyshapeindexisassociatedwithendothelialdysfunctioninbothmenandwomen AT kazuakichayama bodyshapeindexisassociatedwithendothelialdysfunctioninbothmenandwomen AT chikaragoto bodyshapeindexisassociatedwithendothelialdysfunctioninbothmenandwomen AT farinamohamadyusoff bodyshapeindexisassociatedwithendothelialdysfunctioninbothmenandwomen AT ayumunakashima bodyshapeindexisassociatedwithendothelialdysfunctioninbothmenandwomen AT yukihitohigashi bodyshapeindexisassociatedwithendothelialdysfunctioninbothmenandwomen |
| _version_ |
1718377016509595648 |