<italic toggle="yes">Cryptococcus</italic> at Work: Gene Expression during Human Infection

ABSTRACT Meningitis is a frequent manifestation of infection due to Cryptococcus neoformans and a major cause of increased morbidity in patients with AIDS. Numerous in vitro gene expression and genetic studies of the fungus have predicted a myriad of genes, pathways, and biological processes that ma...

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Autores principales:	Rajendra Upadhya, Maureen J. Donlin, Jennifer K. Lodge
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2014
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/4450328c6774442a91f25b44cb65b557
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spelling	oai:doaj.org-article:4450328c6774442a91f25b44cb65b5572021-11-15T15:45:14Z<italic toggle="yes">Cryptococcus</italic> at Work: Gene Expression during Human Infection10.1128/mBio.01097-142150-7511https://doaj.org/article/4450328c6774442a91f25b44cb65b5572014-05-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01097-14https://doaj.org/toc/2150-7511ABSTRACT Meningitis is a frequent manifestation of infection due to Cryptococcus neoformans and a major cause of increased morbidity in patients with AIDS. Numerous in vitro gene expression and genetic studies of the fungus have predicted a myriad of genes, pathways, and biological processes that may be critical for pathogenesis, and many studies using animal models have supported the role of these processes during infection. However, the relevance of these hypotheses based on in vitro and animal models has often been questioned. A recent study by Chen et al. [Y. Chen, D. L. Toffaletti, J. L. Tenor, A. P. Litvintseva, C. Fang, T. G. Mitchell, T. R. McDonald, K. Nielsen, D. R. Boulware, T. Bicanic, and J. R. Perfect, mBio 5(1):e01087-13, 2014] represents an important step in understanding the cryptococcal response during human infection.Rajendra UpadhyaMaureen J. DonlinJennifer K. LodgeAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 5, Iss 2 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Rajendra Upadhya Maureen J. Donlin Jennifer K. Lodge <italic toggle="yes">Cryptococcus</italic> at Work: Gene Expression during Human Infection
description	ABSTRACT Meningitis is a frequent manifestation of infection due to Cryptococcus neoformans and a major cause of increased morbidity in patients with AIDS. Numerous in vitro gene expression and genetic studies of the fungus have predicted a myriad of genes, pathways, and biological processes that may be critical for pathogenesis, and many studies using animal models have supported the role of these processes during infection. However, the relevance of these hypotheses based on in vitro and animal models has often been questioned. A recent study by Chen et al. [Y. Chen, D. L. Toffaletti, J. L. Tenor, A. P. Litvintseva, C. Fang, T. G. Mitchell, T. R. McDonald, K. Nielsen, D. R. Boulware, T. Bicanic, and J. R. Perfect, mBio 5(1):e01087-13, 2014] represents an important step in understanding the cryptococcal response during human infection.
format	article
author	Rajendra Upadhya Maureen J. Donlin Jennifer K. Lodge
author_facet	Rajendra Upadhya Maureen J. Donlin Jennifer K. Lodge
author_sort	Rajendra Upadhya
title	<italic toggle="yes">Cryptococcus</italic> at Work: Gene Expression during Human Infection
title_short	<italic toggle="yes">Cryptococcus</italic> at Work: Gene Expression during Human Infection
title_full	<italic toggle="yes">Cryptococcus</italic> at Work: Gene Expression during Human Infection
title_fullStr	<italic toggle="yes">Cryptococcus</italic> at Work: Gene Expression during Human Infection
title_full_unstemmed	<italic toggle="yes">Cryptococcus</italic> at Work: Gene Expression during Human Infection
title_sort	<italic toggle="yes">cryptococcus</italic> at work: gene expression during human infection
publisher	American Society for Microbiology
publishDate	2014
url	https://doaj.org/article/4450328c6774442a91f25b44cb65b557
work_keys_str_mv	AT rajendraupadhya italictoggleyescryptococcusitalicatworkgeneexpressionduringhumaninfection AT maureenjdonlin italictoggleyescryptococcusitalicatworkgeneexpressionduringhumaninfection AT jenniferklodge italictoggleyescryptococcusitalicatworkgeneexpressionduringhumaninfection
_version_	1718427578607337472

<italic toggle="yes">Cryptococcus</italic> at Work: Gene Expression during Human Infection

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