Absence of Grail promotes CD8+ T cell anti-tumour activity

Grail is an E3 ubiquitin ligase that inhibits T-cell receptor signalling in CD4+ T cells. Here the authors show Grail also limits IL-21 receptor expression and function in CD8+ T cells, is overactive in these cells in patients with lymphoma, and promotes tumour development in a lymphoma transplant m...

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Autores principales:	Cara Haymaker, Yi Yang, Junmei Wang, Qiang Zou, Anupama Sahoo, Andrei Alekseev, Divyendu Singh, Krit Ritthipichai, Yared Hailemichael, Oanh N. Hoang, Hong Qin, Kimberly S. Schluns, Tiejun Wang, Willem W. Overwijk, Shao-Cong Sun, Chantale Bernatchez, Larry W. Kwak, Sattva S. Neelapu, Roza Nurieva
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4450d2168a5641f593a18e67e984d580
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spelling	oai:doaj.org-article:4450d2168a5641f593a18e67e984d5802021-12-02T10:48:28ZAbsence of Grail promotes CD8+ T cell anti-tumour activity10.1038/s41467-017-00252-w2041-1723https://doaj.org/article/4450d2168a5641f593a18e67e984d5802017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00252-whttps://doaj.org/toc/2041-1723Grail is an E3 ubiquitin ligase that inhibits T-cell receptor signalling in CD4+ T cells. Here the authors show Grail also limits IL-21 receptor expression and function in CD8+ T cells, is overactive in these cells in patients with lymphoma, and promotes tumour development in a lymphoma transplant mouse model.Cara HaymakerYi YangJunmei WangQiang ZouAnupama SahooAndrei AlekseevDivyendu SinghKrit RitthipichaiYared HailemichaelOanh N. HoangHong QinKimberly S. SchlunsTiejun WangWillem W. OverwijkShao-Cong SunChantale BernatchezLarry W. KwakSattva S. NeelapuRoza NurievaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Cara Haymaker Yi Yang Junmei Wang Qiang Zou Anupama Sahoo Andrei Alekseev Divyendu Singh Krit Ritthipichai Yared Hailemichael Oanh N. Hoang Hong Qin Kimberly S. Schluns Tiejun Wang Willem W. Overwijk Shao-Cong Sun Chantale Bernatchez Larry W. Kwak Sattva S. Neelapu Roza Nurieva Absence of Grail promotes CD8+ T cell anti-tumour activity
description	Grail is an E3 ubiquitin ligase that inhibits T-cell receptor signalling in CD4+ T cells. Here the authors show Grail also limits IL-21 receptor expression and function in CD8+ T cells, is overactive in these cells in patients with lymphoma, and promotes tumour development in a lymphoma transplant mouse model.
format	article
author	Cara Haymaker Yi Yang Junmei Wang Qiang Zou Anupama Sahoo Andrei Alekseev Divyendu Singh Krit Ritthipichai Yared Hailemichael Oanh N. Hoang Hong Qin Kimberly S. Schluns Tiejun Wang Willem W. Overwijk Shao-Cong Sun Chantale Bernatchez Larry W. Kwak Sattva S. Neelapu Roza Nurieva
author_facet	Cara Haymaker Yi Yang Junmei Wang Qiang Zou Anupama Sahoo Andrei Alekseev Divyendu Singh Krit Ritthipichai Yared Hailemichael Oanh N. Hoang Hong Qin Kimberly S. Schluns Tiejun Wang Willem W. Overwijk Shao-Cong Sun Chantale Bernatchez Larry W. Kwak Sattva S. Neelapu Roza Nurieva
author_sort	Cara Haymaker
title	Absence of Grail promotes CD8+ T cell anti-tumour activity
title_short	Absence of Grail promotes CD8+ T cell anti-tumour activity
title_full	Absence of Grail promotes CD8+ T cell anti-tumour activity
title_fullStr	Absence of Grail promotes CD8+ T cell anti-tumour activity
title_full_unstemmed	Absence of Grail promotes CD8+ T cell anti-tumour activity
title_sort	absence of grail promotes cd8+ t cell anti-tumour activity
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4450d2168a5641f593a18e67e984d580
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Absence of Grail promotes CD8+ T cell anti-tumour activity

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