Structural basis of ALC1/CHD1L autoinhibition and the mechanism of activation by the nucleosome

The oncogenic chromatin remodeler ALC1 (amplification in liver cancer 1), also known as CHD1L is an ATP-dependent chromatin remodeler that relaxes chromatin and plays an important role in the poly(ADP-ribose) polymerase 1 -mediated DNA repair pathway. Here, the authors present the ALC1 crystal struc...

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Autores principales:	Li Wang, Kangjing Chen, Zhucheng Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4457093c89ec4a8385511fc9c82a9b3c
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spelling	oai:doaj.org-article:4457093c89ec4a8385511fc9c82a9b3c2021-12-02T16:10:52ZStructural basis of ALC1/CHD1L autoinhibition and the mechanism of activation by the nucleosome10.1038/s41467-021-24320-42041-1723https://doaj.org/article/4457093c89ec4a8385511fc9c82a9b3c2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24320-4https://doaj.org/toc/2041-1723The oncogenic chromatin remodeler ALC1 (amplification in liver cancer 1), also known as CHD1L is an ATP-dependent chromatin remodeler that relaxes chromatin and plays an important role in the poly(ADP-ribose) polymerase 1 -mediated DNA repair pathway. Here, the authors present the ALC1 crystal structure and a cryo-EM structure of ALC1 bound to a nucleosome, which reveal that ALC1 is autoinhibited and how it becomes activated.Li WangKangjing ChenZhucheng ChenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Li Wang Kangjing Chen Zhucheng Chen Structural basis of ALC1/CHD1L autoinhibition and the mechanism of activation by the nucleosome
description	The oncogenic chromatin remodeler ALC1 (amplification in liver cancer 1), also known as CHD1L is an ATP-dependent chromatin remodeler that relaxes chromatin and plays an important role in the poly(ADP-ribose) polymerase 1 -mediated DNA repair pathway. Here, the authors present the ALC1 crystal structure and a cryo-EM structure of ALC1 bound to a nucleosome, which reveal that ALC1 is autoinhibited and how it becomes activated.
format	article
author	Li Wang Kangjing Chen Zhucheng Chen
author_facet	Li Wang Kangjing Chen Zhucheng Chen
author_sort	Li Wang
title	Structural basis of ALC1/CHD1L autoinhibition and the mechanism of activation by the nucleosome
title_short	Structural basis of ALC1/CHD1L autoinhibition and the mechanism of activation by the nucleosome
title_full	Structural basis of ALC1/CHD1L autoinhibition and the mechanism of activation by the nucleosome
title_fullStr	Structural basis of ALC1/CHD1L autoinhibition and the mechanism of activation by the nucleosome
title_full_unstemmed	Structural basis of ALC1/CHD1L autoinhibition and the mechanism of activation by the nucleosome
title_sort	structural basis of alc1/chd1l autoinhibition and the mechanism of activation by the nucleosome
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4457093c89ec4a8385511fc9c82a9b3c
work_keys_str_mv	AT liwang structuralbasisofalc1chd1lautoinhibitionandthemechanismofactivationbythenucleosome AT kangjingchen structuralbasisofalc1chd1lautoinhibitionandthemechanismofactivationbythenucleosome AT zhuchengchen structuralbasisofalc1chd1lautoinhibitionandthemechanismofactivationbythenucleosome
_version_	1718384406772580352

Structural basis of ALC1/CHD1L autoinhibition and the mechanism of activation by the nucleosome

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