Vaccine-induced, but not natural immunity, against the Streptococcal inhibitor of complement protects against invasive disease

Abstract Highly pathogenic emm1 Streptococcus pyogenes strains secrete the multidomain Streptococcal inhibitor of complement (SIC) that binds and inactivates components of the innate immune response. We aimed to determine if naturally occurring or vaccine-induced antibodies to SIC are protective aga...

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Autores principales:	Lionel K. K. Tan, Mark Reglinski, Daryl Teo, Nada Reza, Lucy E. M. Lamb, Vaitehi Nageshwaran, Claire E. Turner, Mats Wikstrom, Inga-Maria Frick, Lars Bjorck, Shiranee Sriskandan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/445c3bbbceec45f2be2bdc2c075e8bd3
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spelling	oai:doaj.org-article:445c3bbbceec45f2be2bdc2c075e8bd32021-12-02T18:27:46ZVaccine-induced, but not natural immunity, against the Streptococcal inhibitor of complement protects against invasive disease10.1038/s41541-021-00326-32059-0105https://doaj.org/article/445c3bbbceec45f2be2bdc2c075e8bd32021-04-01T00:00:00Zhttps://doi.org/10.1038/s41541-021-00326-3https://doaj.org/toc/2059-0105Abstract Highly pathogenic emm1 Streptococcus pyogenes strains secrete the multidomain Streptococcal inhibitor of complement (SIC) that binds and inactivates components of the innate immune response. We aimed to determine if naturally occurring or vaccine-induced antibodies to SIC are protective against invasive S. pyogenes infection. Immunisation with full-length SIC protected mice against systemic bacterial dissemination following intranasal or intramuscular infection with emm1 S. pyogenes. Vaccine-induced rabbit anti-SIC antibodies, but not naturally occurring human anti-SIC antibodies, enhanced bacterial clearance in an ex vivo whole-blood assay. SIC vaccination of both mice and rabbits resulted in antibody recognition of all domains of SIC, whereas naturally occurring human anti-SIC antibodies recognised the proline-rich region of SIC only. We, therefore, propose a model whereby natural infection with S. pyogenes generates non-protective antibodies against the proline-rich region of SIC, while vaccination with full-length SIC permits the development of protective antibodies against all SIC domains.Lionel K. K. TanMark ReglinskiDaryl TeoNada RezaLucy E. M. LambVaitehi NageshwaranClaire E. TurnerMats WikstromInga-Maria FrickLars BjorckShiranee SriskandanNature PortfolioarticleImmunologic diseases. AllergyRC581-607Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Vaccines, Vol 6, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Lionel K. K. Tan Mark Reglinski Daryl Teo Nada Reza Lucy E. M. Lamb Vaitehi Nageshwaran Claire E. Turner Mats Wikstrom Inga-Maria Frick Lars Bjorck Shiranee Sriskandan Vaccine-induced, but not natural immunity, against the Streptococcal inhibitor of complement protects against invasive disease
description	Abstract Highly pathogenic emm1 Streptococcus pyogenes strains secrete the multidomain Streptococcal inhibitor of complement (SIC) that binds and inactivates components of the innate immune response. We aimed to determine if naturally occurring or vaccine-induced antibodies to SIC are protective against invasive S. pyogenes infection. Immunisation with full-length SIC protected mice against systemic bacterial dissemination following intranasal or intramuscular infection with emm1 S. pyogenes. Vaccine-induced rabbit anti-SIC antibodies, but not naturally occurring human anti-SIC antibodies, enhanced bacterial clearance in an ex vivo whole-blood assay. SIC vaccination of both mice and rabbits resulted in antibody recognition of all domains of SIC, whereas naturally occurring human anti-SIC antibodies recognised the proline-rich region of SIC only. We, therefore, propose a model whereby natural infection with S. pyogenes generates non-protective antibodies against the proline-rich region of SIC, while vaccination with full-length SIC permits the development of protective antibodies against all SIC domains.
format	article
author	Lionel K. K. Tan Mark Reglinski Daryl Teo Nada Reza Lucy E. M. Lamb Vaitehi Nageshwaran Claire E. Turner Mats Wikstrom Inga-Maria Frick Lars Bjorck Shiranee Sriskandan
author_facet	Lionel K. K. Tan Mark Reglinski Daryl Teo Nada Reza Lucy E. M. Lamb Vaitehi Nageshwaran Claire E. Turner Mats Wikstrom Inga-Maria Frick Lars Bjorck Shiranee Sriskandan
author_sort	Lionel K. K. Tan
title	Vaccine-induced, but not natural immunity, against the Streptococcal inhibitor of complement protects against invasive disease
title_short	Vaccine-induced, but not natural immunity, against the Streptococcal inhibitor of complement protects against invasive disease
title_full	Vaccine-induced, but not natural immunity, against the Streptococcal inhibitor of complement protects against invasive disease
title_fullStr	Vaccine-induced, but not natural immunity, against the Streptococcal inhibitor of complement protects against invasive disease
title_full_unstemmed	Vaccine-induced, but not natural immunity, against the Streptococcal inhibitor of complement protects against invasive disease
title_sort	vaccine-induced, but not natural immunity, against the streptococcal inhibitor of complement protects against invasive disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/445c3bbbceec45f2be2bdc2c075e8bd3
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Vaccine-induced, but not natural immunity, against the Streptococcal inhibitor of complement protects against invasive disease

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