The red flags of ulnar neuropathy in leprosy

The diagnosis of pure neural leprosy is more challenging because patients share characteristics with other common pathologies, such as ulnar compression, which should be taken into consideration for differential diagnosis. In this study, we identify ulnar nerve conduction characteristics to aid in t...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Márcia Jardim, Robson T. Vital, Ximena Illarramendi, Mariana Hacker, Beatriz Junqueira, Izabela J. R. Pitta, Roberta O. Pinheiro, Euzenir N. Sarno
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/445f78c0948c467899aebe719223815e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:445f78c0948c467899aebe719223815e
record_format	dspace
spelling	oai:doaj.org-article:445f78c0948c467899aebe719223815e2021-11-25T06:19:27ZThe red flags of ulnar neuropathy in leprosy1932-6203https://doaj.org/article/445f78c0948c467899aebe719223815e2021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604365/?tool=EBIhttps://doaj.org/toc/1932-6203The diagnosis of pure neural leprosy is more challenging because patients share characteristics with other common pathologies, such as ulnar compression, which should be taken into consideration for differential diagnosis. In this study, we identify ulnar nerve conduction characteristics to aid in the differential diagnosis of ulnar neuropathy (UN) in leprosy and that of non-leprosy etiology. In addition, we include putative markers to better understand the inflammatory process that may occur in the nerve. Data were extracted from a database of people affected by leprosy (leprosy group) diagnosed with UN at leprosy diagnosis. A non-leprosy group of patients diagnosed with mechanical neuropathy (compressive, traumatic) was also included. Both groups were submitted to clinical, neurological, neurophysiological and immunological studies. Nerve enlargement and sensory impairment were significantly higher in leprosy patients than in patients with compressive UN. Bilateral impairment was significantly higher in the leprosy group than in the non-leprosy group. Leprosy reactions were associated to focal demyelinating lesions at the elbow and to temporal dispersion (TD). Clinical signs such as sensory impairment, nerve enlargement and bilateral ulnar nerve injury associated with eletrodiagnostic criteria such as demyelinating finds, specifically temporal dispersion, could be tools to help us decided on the best conduct in patients with elbow ulnar neuropathy and specifically decide if we should perform a nerve biopsy for diagnosis of pure neural leprosy.Márcia JardimRobson T. VitalXimena IllarramendiMariana HackerBeatriz JunqueiraIzabela J. R. PittaRoberta O. PinheiroEuzenir N. SarnoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Márcia Jardim Robson T. Vital Ximena Illarramendi Mariana Hacker Beatriz Junqueira Izabela J. R. Pitta Roberta O. Pinheiro Euzenir N. Sarno The red flags of ulnar neuropathy in leprosy
description	The diagnosis of pure neural leprosy is more challenging because patients share characteristics with other common pathologies, such as ulnar compression, which should be taken into consideration for differential diagnosis. In this study, we identify ulnar nerve conduction characteristics to aid in the differential diagnosis of ulnar neuropathy (UN) in leprosy and that of non-leprosy etiology. In addition, we include putative markers to better understand the inflammatory process that may occur in the nerve. Data were extracted from a database of people affected by leprosy (leprosy group) diagnosed with UN at leprosy diagnosis. A non-leprosy group of patients diagnosed with mechanical neuropathy (compressive, traumatic) was also included. Both groups were submitted to clinical, neurological, neurophysiological and immunological studies. Nerve enlargement and sensory impairment were significantly higher in leprosy patients than in patients with compressive UN. Bilateral impairment was significantly higher in the leprosy group than in the non-leprosy group. Leprosy reactions were associated to focal demyelinating lesions at the elbow and to temporal dispersion (TD). Clinical signs such as sensory impairment, nerve enlargement and bilateral ulnar nerve injury associated with eletrodiagnostic criteria such as demyelinating finds, specifically temporal dispersion, could be tools to help us decided on the best conduct in patients with elbow ulnar neuropathy and specifically decide if we should perform a nerve biopsy for diagnosis of pure neural leprosy.
format	article
author	Márcia Jardim Robson T. Vital Ximena Illarramendi Mariana Hacker Beatriz Junqueira Izabela J. R. Pitta Roberta O. Pinheiro Euzenir N. Sarno
author_facet	Márcia Jardim Robson T. Vital Ximena Illarramendi Mariana Hacker Beatriz Junqueira Izabela J. R. Pitta Roberta O. Pinheiro Euzenir N. Sarno
author_sort	Márcia Jardim
title	The red flags of ulnar neuropathy in leprosy
title_short	The red flags of ulnar neuropathy in leprosy
title_full	The red flags of ulnar neuropathy in leprosy
title_fullStr	The red flags of ulnar neuropathy in leprosy
title_full_unstemmed	The red flags of ulnar neuropathy in leprosy
title_sort	red flags of ulnar neuropathy in leprosy
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/445f78c0948c467899aebe719223815e
work_keys_str_mv	AT marciajardim theredflagsofulnarneuropathyinleprosy AT robsontvital theredflagsofulnarneuropathyinleprosy AT ximenaillarramendi theredflagsofulnarneuropathyinleprosy AT marianahacker theredflagsofulnarneuropathyinleprosy AT beatrizjunqueira theredflagsofulnarneuropathyinleprosy AT izabelajrpitta theredflagsofulnarneuropathyinleprosy AT robertaopinheiro theredflagsofulnarneuropathyinleprosy AT euzenirnsarno theredflagsofulnarneuropathyinleprosy AT marciajardim redflagsofulnarneuropathyinleprosy AT robsontvital redflagsofulnarneuropathyinleprosy AT ximenaillarramendi redflagsofulnarneuropathyinleprosy AT marianahacker redflagsofulnarneuropathyinleprosy AT beatrizjunqueira redflagsofulnarneuropathyinleprosy AT izabelajrpitta redflagsofulnarneuropathyinleprosy AT robertaopinheiro redflagsofulnarneuropathyinleprosy AT euzenirnsarno redflagsofulnarneuropathyinleprosy
_version_	1718413859921854464

The red flags of ulnar neuropathy in leprosy

Ejemplares similares