Linking type 2 diabetes mellitus, cardiac hypertrophy and depression in a diurnal animal model

Abstract It was recently suggested that the Metabolic Syndrome should be renamed to “Circadian Syndrome”. In this context, we explored the effects of living under standard laboratory conditions, where light is the only cycling variable (relevant to human modern life), in a diurnal mammal, on the rel...

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Autores principales:	Carmel Bilu, Haim Einat, Orly Barak, Paul Zimmet, Vicktoria Vishnevskia-Dai, Amanda Govrin, Galila Agam, Noga Kronfeld-Schor
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/446033567ee14e8591994600c9ec7846
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spelling	oai:doaj.org-article:446033567ee14e8591994600c9ec78462021-12-02T16:08:04ZLinking type 2 diabetes mellitus, cardiac hypertrophy and depression in a diurnal animal model10.1038/s41598-019-48326-72045-2322https://doaj.org/article/446033567ee14e8591994600c9ec78462019-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-48326-7https://doaj.org/toc/2045-2322Abstract It was recently suggested that the Metabolic Syndrome should be renamed to “Circadian Syndrome”. In this context, we explored the effects of living under standard laboratory conditions, where light is the only cycling variable (relevant to human modern life), in a diurnal mammal, on the relationships between affective-like pathology, type 2 diabetes mellitus (T2DM), and cardiac hypertrophy. After 20 weeks, some of the animals spontaneously developed T2DM, depressive and anxiety-like behavior and cardiac hypertrophy. There were significant correlations between levels of anxiety-like behavior and glucose tolerance, and between heart/total body weight ratio and glucose tolerance. Our data suggest a relationship between the development of T2DM, emotional and cardiac pathology as seen in diurnal humans. Furthermore, our data show a possible relationship between reduced daily cycling cues in the laboratory and what has been regularly termed “Metabolic Syndrome” and recently proposed by us to be renamed to “Circadian Syndrome”.Carmel BiluHaim EinatOrly BarakPaul ZimmetVicktoria Vishnevskia-DaiAmanda GovrinGalila AgamNoga Kronfeld-SchorNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-7 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Carmel Bilu Haim Einat Orly Barak Paul Zimmet Vicktoria Vishnevskia-Dai Amanda Govrin Galila Agam Noga Kronfeld-Schor Linking type 2 diabetes mellitus, cardiac hypertrophy and depression in a diurnal animal model
description	Abstract It was recently suggested that the Metabolic Syndrome should be renamed to “Circadian Syndrome”. In this context, we explored the effects of living under standard laboratory conditions, where light is the only cycling variable (relevant to human modern life), in a diurnal mammal, on the relationships between affective-like pathology, type 2 diabetes mellitus (T2DM), and cardiac hypertrophy. After 20 weeks, some of the animals spontaneously developed T2DM, depressive and anxiety-like behavior and cardiac hypertrophy. There were significant correlations between levels of anxiety-like behavior and glucose tolerance, and between heart/total body weight ratio and glucose tolerance. Our data suggest a relationship between the development of T2DM, emotional and cardiac pathology as seen in diurnal humans. Furthermore, our data show a possible relationship between reduced daily cycling cues in the laboratory and what has been regularly termed “Metabolic Syndrome” and recently proposed by us to be renamed to “Circadian Syndrome”.
format	article
author	Carmel Bilu Haim Einat Orly Barak Paul Zimmet Vicktoria Vishnevskia-Dai Amanda Govrin Galila Agam Noga Kronfeld-Schor
author_facet	Carmel Bilu Haim Einat Orly Barak Paul Zimmet Vicktoria Vishnevskia-Dai Amanda Govrin Galila Agam Noga Kronfeld-Schor
author_sort	Carmel Bilu
title	Linking type 2 diabetes mellitus, cardiac hypertrophy and depression in a diurnal animal model
title_short	Linking type 2 diabetes mellitus, cardiac hypertrophy and depression in a diurnal animal model
title_full	Linking type 2 diabetes mellitus, cardiac hypertrophy and depression in a diurnal animal model
title_fullStr	Linking type 2 diabetes mellitus, cardiac hypertrophy and depression in a diurnal animal model
title_full_unstemmed	Linking type 2 diabetes mellitus, cardiac hypertrophy and depression in a diurnal animal model
title_sort	linking type 2 diabetes mellitus, cardiac hypertrophy and depression in a diurnal animal model
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/446033567ee14e8591994600c9ec7846
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Linking type 2 diabetes mellitus, cardiac hypertrophy and depression in a diurnal animal model

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